Education
B.S. in Molecular Biology and Biochemistry, Simon Fraser University, 2010
Current position
Doctoral student in Experimental Medicine, Department of Medicine, McGill University, Montreal, Canada
Publications
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Methot, S. P. and Di Noia, J. M. (2015). Pharmacological manipulation of AID. Oncotarget 6(29): 26550-26551.
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Methot, S. P., Litzler, L. C., Trajtenberg, F., Zahn, A., Robert, F., Pelletier, J., Buschiazzo, A., Magor, B. G. and Di Noia, J. M. (2015). Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm. J Exp Med 212(4): 581-596.
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Zahn, A., Eranki, A. K., Patenaude, A. M., Methot, S. P., Fifield, H., Cortizas, E. M., Foster, P., Imai, K., Durandy, A., Larijani, M., Verdun, R. E. and Di Noia, J. M. (2014). Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination. Proc Natl Acad Sci U S A 111(11): E988-997.
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Hu, Y., Ericsson, I., Torseth, K., Methot, S. P., Sundheim, O., Liabakk, N. B., Slupphaug, G., Di Noia, J. M., Krokan, H. E. and Kavli, B. (2013). A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching. J Mol Biol 425(2): 424-443.
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Baker, J. H., Kyle, A. H., Bartels, K. L., Methot, S. P., Flanagan, E. J., Balbirnie, A., Cran, J. D. and Minchinton, A. I. (2013). Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin. PLoS One 8(10): e76832.
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Orthwein, A., Zahn, A., Methot, S. P., Godin, D., Conticello, S. G., Terada, K. and Di Noia, J. M. (2012). Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. EMBO J 31(3): 679-691.
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Poon, L. C., Methot, S. P., Morabi-Pazooki, W., Pio, F., Bennet, A. J. and Sen, D. (2011). Guanine-rich RNAs and DNAs that bind heme robustly catalyze oxygen transfer reactions. J Am Chem Soc 133(6): 1877-1884.