Paul Préfontaine
  • Neuroscience Laboratory, CHU de Quebec Research Center and department of Molecular Medicine, Faculty of Medicine, Laval University, Canada
Research fields
  • Neuroscience
Personal information


M.S. in Immunology, Laval University, 2002

Current position

Research professionnal in Dr Serge Rivest lab., CRCHUQ, Canada


  1. Lampron, A., Larochelle, A., Laflamme, N., Préfontaine, P., Plante, M. M., Sánchez, M. G., Yong, V. W., Stys, P. K., Tremblay, M. È. and Rivest, S. (2015). Inefficient clearance of myelin debris by microglia impairs remyelinating processes. J Exp Med 212(4): 481-495.
  2. ElAli, A., Thériault, P., Préfontaine, P. and Rivest, S. (2013). Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation. Acta Neuropathol Commun 1: 75.
  3. Michaud, J. P., Bellavance, M. A., Préfontaine, P. and Rivest, S. (2013). Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta. Cell Rep 5(3): 646-653.
  4. Michaud, J. P., Hallé, M., Lampron, A., Thériault, P., Préfontaine, P., Filali, M., Tribout-Jover, P., Lanteigne, A. M., Jodoin, R., Cluff, C., Brichard, V., Palmantier, R., Pilorget, A., Larocque, D. and Rivest, S. (2013). Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology. Proc Natl Acad Sci U S A 110(5): 1941-1946.
  5. Richard, K. L., Filali, M., Préfontaine, P. and Rivest, S. (2008). Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci 28(22): 5784-5793.
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