Maxime M Mahe
  • Department of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, USA
Research fields
  • Cell biology
Personal information


Ph.D. in Neurogastroenterology, University of Nantes, Nantes, 2012

Current position

Research Instructor, Cincinnati Children's Hospital Medical Center, Division of Fetal and Thoracic Pediatric Surgery, Cincinnati, OH (2015-present)


  1. Bertaux-Skeirik, N., Feng, R., Schumacher, M. A., Li, J., Mahe, M. M., Engevik, A. C., Javier, J. E., Peek, R. M., Jr., Ottemann, K., Orian-Rousseau, V., Boivin, G. P., Helmrath, M. A. and Zavros, Y. (2015). CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog 11(2): e1004663.
  2. Mahe, M. M., Sundaram, N., Watson, C. L., Shroyer, N. F. and Helmrath, M. A. (2015). Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy. J Vis Exp(97).
  3. Moore, S. R., Guedes, M. M., Costa, T. B., Vallance, J., Maier, E. A., Betz, K. J., Aihara, E., Mahe, M. M., Lima, A. A., Oria, R. B. and Shroyer, N. F. (2015). Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids. Am J Physiol Gastrointest Liver Physiol 308(10): G831-839.
  4. Finkbeiner, S. R., Hill, D. R., Altheim, C. H., Dedhia, P. H., Taylor, M. J., Tsai, Y. H., Chin, A. M., Mahe, M. M., Watson, C. L., Freeman, J. J., Nattiv, R., Thomson, M., Klein, O. D., Shroyer, N. F., Helmrath, M. A., Teitelbaum, D. H., Dempsey, P. J. and Spence, J. R. (2015). Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports.
  5. Watson, C. L., Mahe, M. M., Munera, J., Howell, J. C., Sundaram, N., Poling, H. M., Schweitzer, J. I., Vallance, J. E., Mayhew, C. N., Sun, Y., Grabowski, G., Finkbeiner, S. R., Spence, J. R., Shroyer, N. F., Wells, J. M. and Helmrath, M. A. (2014). An in vivo model of human small intestine using pluripotent stem cells. Nat Med 20(11): 1310-1314.
  6. Neunlist, M., Van Landeghem, L., Mahe, M. M., Derkinderen, P., des Varannes, S. B. and Rolli-Derkinderen, M. (2013). The digestive neuronal-glial-epithelial unit: a new actor in gut health and disease. Nat Rev Gastroenterol Hepatol 10(2): 90-100.
  7. Wang, F., Scoville, D., He, X. C., Mahe, M. M., Box, A., Perry, J. M., Smith, N. R., Lei, N. Y., Davies, P. S., Fuller, M. K., Haug, J. S., McClain, M., Gracz, A. D., Ding, S., Stelzner, M., Dunn, J. C., Magness, S. T., Wong, M. H., Martin, M. G., Helmrath, M. and Li, L. (2013). Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology 145(2): 383-395 e381-321.
  8. Fuller, M. K., Faulk, D. M., Sundaram, N., Mahe, M. M., Stout, K. M., von Furstenberg, R. J., Smith, B. J., McNaughton, K. K., Shroyer, N. F., Helmrath, M. A. and Henning, S. J. (2013). Intestinal stem cells remain viable after prolonged tissue storage. Cell Tissue Res 354(2): 441-450.
  9. Mahe, M. M., Aihara, E., Schumacher, M. A., Zavros, Y., Montrose, M. H., Helmrath, M. A., Sato, T. and Shroyer, N. F. (2013). Establishment of Gastrointestinal Epithelial Organoids. Curr Protoc Mouse Biol 3(4): 217-240.
  10. Abdo, H., Mahe, M. M., Derkinderen, P., Bach-Ngohou, K., Neunlist, M. and Lardeux, B. (2012). The omega-6 fatty acid derivative 15-deoxy-Delta(1)(2),(1)(4)-prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress. J Physiol 590(Pt 11): 2739-2750.
  11. Coron, E., Auksorius, E., Pieretti, A., Mahe, M. M., Liu, L., Steiger, C., Bromberg, Y., Bouma, B., Tearney, G., Neunlist, M. and Goldstein, A. M. (2012). Full-field optical coherence microscopy is a novel technique for imaging enteric ganglia in the gastrointestinal tract. Neurogastroenterol Motil 24(12): e611-621.
  12. Flamant, M., Aubert, P., Rolli-Derkinderen, M., Bourreille, A., Neunlist, M. R., Mahe, M. M., Meurette, G., Marteyn, B., Savidge, T., Galmiche, J. P., Sansonetti, P. J. and Neunlist, M. (2011). Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione. Gut 60(4): 473-484.
  13. Van Landeghem, L., Chevalier, J., Mahe, M. M., Wedel, T., Urvil, P., Derkinderen, P., Savidge, T. and Neunlist, M. (2011). Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF. Am J Physiol Gastrointest Liver Physiol 300(6): G976-987.
  14. Bach-Ngohou, K., Mahe, M. M., Aubert, P., Abdo, H., Boni, S., Bourreille, A., Denis, M. G., Lardeux, B., Neunlist, M. and Masson, D. (2010). Enteric glia modulate epithelial cell proliferation and differentiation through 15-deoxy-12,14-prostaglandin J2. J Physiol 588(Pt 14): 2533-2544.
  15. Paillusson, S., Tasselli, M., Lebouvier, T., Mahe, M. M., Chevalier, J., Biraud, M., Cario-Toumaniantz, C., Neunlist, M. and Derkinderen, P. (2010). alpha-Synuclein expression is induced by depolarization and cyclic AMP in enteric neurons. J Neurochem 115(3): 694-706.
  16. Van Landeghem, L., Mahe, M. M., Teusan, R., Leger, J., Guisle, I., Houlgatte, R. and Neunlist, M. (2009). Regulation of intestinal epithelial cells transcriptome by enteric glial cells: impact on intestinal epithelial barrier functions. BMC Genomics 10: 507.
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