Beat Bornhauser Department of Oncology and Children’s Research Center, University Children's Hospital Zurich, Switzerland
1 protocol

Jean-Pierre Bourquin Department of Oncology and Children’s Research Center, University Children’s Hospital Zurich, Switzerland
1 protocol

Adriano Aguzzi Institute of Neuropathology, University Hospital of Zurich, Switzerland
1 protocol

Pawel Pelczar Institute of Laboratory Animal Science, University of Zurich, Switzerland
1 protocol
Alessandro Didonna East Carolina University
80 protocols

Dhiman Pal Johns Hopkins University School of Medicine
7 protocols

Esteban Paredes-Osses Institute of Public Health, Chile
9 protocols

Mohan Babu Stanford University
7 protocols

Reviewer
Scott McComb
  • Research scientist, National Research Council of Canada, Human Health and Thereapeutics Research Centre
Research focus
  • CAR-T, cancer immunology, cell death
  • 1 Author merit

Education

PhD, University of Ottawa, 2013

Lab information

The Scott McComb lab focuses on research into chimeric antigen receptor T cells (CAR-T), genome editing (CRISPR and other technologies), and the mechanisms of cell death. CAR-T is an exciting new avenue to redirect immune cells to target and kill cancer. While breakthroughs in CAR-T therapy have led to life-saving treatments for patients with previously incurable leukemia, such therapies have been less successful against solid tumours. Moreover, the determinants of long term cancer regression in CAR-T treated patients are not yet well understood. Using genome editing, we are dissecting the mechanisms of programmed cell death and other immune signalling pathways in T cells in order to improve their effectiveness against cancer.
https://med.uottawa.ca/bmi/people/mccomb-scott

Publications

https://scholar.google.ca/citations?user=rAAIAKwAAAAJ&hl=en
https://pubmed.ncbi.nlm.nih.gov/31392262/
https://pubmed.ncbi.nlm.nih.gov/33616439/
https://pubmed.ncbi.nlm.nih.gov/32083149/
https://www.biorxiv.org/content/10.1101/2020.10.30.360925v2
1 Protocol published
Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9
CRISPR-Cas9 based knockout strategies are increasingly used to analyze gene function. However, redundancies and overlapping functions in biological signaling pathways can call for generating multi-gene knockout cells, which remains a relatively ...
4 Protocols reviewed
A Rapid FRET Real-Time PCR Protocol for Simultaneous Quantitative Detection and Discrimination of Human Plasmodium Parasites

Malaria is the most important parasitic disease worldwide, and accurate diagnosis and treatment without delay are essential for reducing morbidity and mortality, especially in P. falciparum malaria. Real-time PCR is highly sensitive and highly

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HiSAT: A Novel Method for the Rapid Diagnosis of Allergy
Authors:  Hirotomo Shibaguchi and Yuki Yasutaka, date: 02/05/2022, view: 1357, Q&A: 0

To identify causative substances for allergies to drugs or foods, the lymphocyte transformation test (LTT) is currently widely used as in vitro test, but its accuracy is not satisfactory. We have developed a novel method designated high-sensitivity

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