Scott McComb
  • Research scientist, Human Health Therapeutics Research Centre, National Research Council, Ottawa, Canada
Research fields
  • Immunology, Genome Editing, Cell Death
Personal information


PhD, University of Ottawa, 2013

Lab information

The Scott McComb lab focuses on research into chimeric antigen receptor T cells (CAR-T), genome editing (CRISPR and other technologies), and the mechanisms of cell death. CAR-T is an exciting new avenue to redirect immune cells to target and kill cancer. While breakthroughs in CAR-T therapy have led to life-saving treatments for patients with previously incurable leukemia, such therapies have been less successful against solid tumours. Moreover, the determinants of long term cancer regression in CAR-T treated patients are not yet well understood. Using genome editing, we are dissecting the mechanisms of programmed cell death and other immune signalling pathways in T cells in order to improve their effectiveness against cancer.

Research focus

CAR-T, cancer immunology, cell death

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