Robert Wheeler Molecular & Biomedical Sciences, University of Maine, USA
1 protocol

Alex Hopke
  • Molecular & Biomedical Sciences, University of Maine, USA
Research focus
  • Immunology
  • 1 Author merit


Ph.D, University of Maine, USA, 2016

Current position

Research Fellow, Department of Surgery, Massachusetts General Hospital, USA


  1. Hopke, A., Nicke, N., Hidu, E. E., Degani, G., Popolo, L. and Wheeler, R. T. (2016). Neutrophil Attack Triggers Extracellular Trap-Dependent Candida Cell Wall Remodeling and Altered Immune Recognition. PLoS Pathog 12(5): e1005644.
  2. Hasim, S., Allison, D. P., Retterer, S. T., Hopke, A., Wheeler, R. T., Doktycz, M. J. and Reynolds, T. B. (2017). beta-(1,3)-Glucan Unmasking in Some Candida albicans Mutants Correlates with Increases in Cell Wall Surface Roughness and Decreases in Cell Wall Elasticity. Infect Immun 85(1).
  3. Davis, S. E., Hopke, A., Minkin, S. C., Jr., Montedonico, A. E., Wheeler, R. T. and Reynolds, T. B. (2014). Masking of beta(1-3)-glucan in the cell wall of Candida albicans from detection by innate immune cells depends on phosphatidylserine. Infect Immun 82(10): 4405-4413.
  4. Marakalala, M. J., Vautier, S., Potrykus, J., Walker, L. A., Shepardson, K. M., Hopke, A., Mora-Montes, H. M., Kerrigan, A., Netea, M. G., Murray, G. I., Maccallum, D. M., Wheeler, R., Munro, C. A., Gow, N. A., Cramer, R. A., Brown, A. J. and Brown, G. D. (2013). Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1. PLoS Pathog 9(4): e1003315.
  5. Palmer, R. K., Hutchinson, L. M., Burpee, B. T., Tupper, E. J., Pelletier, J. H., Kormendy, Z., Hopke, A. R., Malay, E. T., Evans, B. L., Velez, A. and Gosse, J. A. (2012). Antibacterial agent triclosan suppresses RBL-2H3 mast cell function. Toxicol Appl Pharmacol 258(1): 99-108.
1 Protocol published
In vitro Detection of Neutrophil Traps and Post-attack Cell Wall Changes in Candida Hyphae
Authors:  Alex Hopke and Robert T. Wheeler, date: 04/05/2017, view: 8534, Q&A: 0
In this protocol we describe how to visualize neutrophil extracellular traps (NETs) and fungal cell wall changes in the context of the coculture of mouse neutrophils with fungal hyphae of Candida albicans. These protocols are easily ...
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