Kobe C. Yuen
  • Senior Scientist, Oncology Biomarker Development, Genentech, USA
Research focus
  • 1 Author merit


Ph.D, Stowers Institute for Medical Research, USA, 2016


  1. Yuen,K.C.,Xu,B.,Krantz,I.D.and Gerton,J.L.(2016). NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR.Cell Rep14(1):93-102.
  2. Zakari,M.,Yuen,K.and Gerton,J.L.(2015). Etiology and pathogenesis of the cohesinopathies.Wiley Interdiscip Rev Dev Biol4(5):489-504.
  3. Aoto,K.,Sandell,L.L.,Butler Tjaden,N.E.,Yuen,K.C.,Watt,K.E.,Black,B.L.,Durnin,M.and Trainor,P.A.(2015). Mef2c-F10N enhancer driven beta-galactosidase(LacZ)and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells.Dev Biol402(1):3-16.
  4. Yuen,C.Y.,Wong,S.L.,Lau,C.W.,Tsang,S.Y.,Xu,A.,Zhu,Z.,Ng,C.F.,Yao,X.,Kong,S.K.,Lee,H.K.and Huang,Y.(2012). From skeleton to cytoskeleton:osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4.Circ Res111(3):e55-66.
  5. Yuen,C.Y.,Wong,W.T.,Tian,X.Y.,Wong,S.L.,Lau,C.W.,Yu,J.,Tomlinson,B.,Yao,X.and Huang,Y.(2011). Telmisartan inhibits vasoconstriction via PPARgamma-dependent expression and activation of endothelial nitric oxide synthase.Cardiovasc Res90(1):122-129.
1 Protocol published
Measurement of RNA-induced PKR Activation in vitro
Author:  Kobe C. Yuen, date: 03/20/2017, view: 7054, Q&A: 0
Protein kinase R (PKR) is one of the key RNA-activated sensors for innate immunity. PKR is activated by pathogenic or aberrant RNAs such as short double-stranded RNAs or those with imperfect secondary structures, as well as a reduction in the amount ...
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