Rosa Barreira da Silva
  • Genentech
Research fields
  • Immunology
Personal information


Ph.D of Biomedical Sciences, Institute of Biomedical Sciences Abel Salazar, University of Porto, Portugal, 2011

Current position

Postdoc, Department of Cancer Immunology, Genentech, South San Francisco, California, USA


  1. Decalf, J., da Silva, R. B., Werneke, S. and Albert, M. L. (2016). Comment on "NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis". Sci Transl Med 8(349): 349le341.
  2. Loi, M., Muller, A., Steinbach, K., Niven, J., Barreira da Silva, R., Paul, P., Ligeon, L. A., Caruso, A., Albrecht, R. A., Becker, A. C., Annaheim, N., Nowag, H., Dengjel, J., Garcia-Sastre, A., Merkler, D., Munz, C. and Gannage, M. (2016). Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses. Cell Rep 15(5): 1076-1087.
  3. Yatim, N., Jusforgues-Saklani, H., Orozco, S., Schulz, O., Barreira da Silva, R., Reis e Sousa, C., Green, D. R., Oberst, A. and Albert, M. L. (2015). RIPK1 and NF-kappaB signaling in dying cells determines cross-priming of CD8(+) T cells. Science 350(6258): 328-334.
  4. Barreira da Silva, R., Laird, M. E., Yatim, N., Fiette, L., Ingersoll, M. A. and Albert, M. L. (2015). Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy. Nat Immunol 16(8): 850-858.
  5. Carvalho, S., Barreira da Silva, R., Shawki, A., Castro, H., Lamy, M., Eide, D., Costa, V., Mackenzie, B. and Tomas, A. M. (2015). LiZIP3 is a cellular zinc transporter that mediates the tightly regulated import of zinc in Leishmania infantum parasites. Mol Microbiol 96(3): 581-595.
  6. Gannage, M., da Silva, R. B. and Munz, C. (2013). Antigen processing for MHC presentation via macroautophagy. Methods Mol Biol 960: 473-488.
  7. Romano, E., Cotari, J. W., Barreira da Silva, R., Betts, B. C., Chung, D. J., Avogadri, F., Fink, M. J., St Angelo, E. T., Mehrara, B., Heller, G., Munz, C., Altan-Bonnet, G. and Young, J. W. (2012). Human Langerhans cells use an IL-15R-alpha/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1. Blood 119(22): 5182-5190.
  8. Barreira da Silva, R., Graf, C. and Münz, C. (2011). Cytoskeletal stabilization of inhibitory interactions in immunological synapses of mature human dendritic with natural killer cells. Blood 118:6487-98.
  9. Barreira da Silva, R. and Munz, C. (2011). Natural killer cell activation by dendritic cells: balancing inhibitory and activating signals. Cell Mol Life Sci 68(21): 3505-3518.
  10. Lunemann, A., Tackenberg, B., DeAngelis, T., da Silva, R. B., Messmer, B., Vanoaica, L. D., Miller, A., Apatoff, B., Lublin, F. D., Lunemann, J. D. and Munz, C. (2011). Impaired IFN-gamma production and proliferation of NK cells in multiple sclerosis. Int Immunol 23(2): 139-148.
  11. Lunemann, A., Lunemann, J. D., Roberts, S., Messmer, B., Barreira da Silva, R., Raine, C. S. and Munz, C. (2008). Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition. J Immunol 181(9): 6170-6177.
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