Paula J. Hurley
  • The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, USA
Research focus
  • Cancer biology
Personal information


Ph.D of Cancer Biology, University of Chicago School of Medicine, Chicago, IL, 2004

Current position

Assistant Professor, Johns Hopkins University School of Medicine

Publications (since 2012)

  1. Goldstein, A., Valda Toro, P., Lee, J., Silberstein, J. L., Nakazawa, M., Waters, I., Cravero, K., Chu, D., Cochran, R. L., Kim, M., Shinn, D., Torquato, S., Hughes, R. M., Pallavajjala, A., Carducci, M. A., Paller, C. J., Denmeade, S. R., Kressel, B., Trock, B. J., Eisenberger, M. A., Antonarakis, E. S., Park, B. H. and Hurley, P. J. (2017). Detection fidelity of AR mutations in plasma derived cell-free DNA. Oncotarget.
  2. Benzon, B., Zhao, S. G., Haffner, M. C., Takhar, M., Erho, N., Yousefi, K., Hurley, P., Bishop, J. L., Tosoian, J., Ghabili, K., Alshalalfa, M., Glavaris, S., Simons, B. W., Tran, P., Davicioni, E., Karnes, R. J., Boudadi, K., Antonarakis, E. S., Schaeffer, E. M., Drake, C. G., Feng, F. and Ross, A. E. (2016). Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis. Prostate Cancer Prostatic Dis.
  3. Matsui, H., Musicki, B., Sopko, N. A., Liu, X., Hurley, P. J., Burnett, A. L., Bivalacqua, T. J. and Hannan, J. L. (2017). Early-stage Type 2 Diabetes Mellitus Impairs Erectile Function and Neurite Outgrowth From the Major Pelvic Ganglion and Downregulates the Gene Expression of Neurotrophic Factors. Urology 99: 287 e281-287 e287.
  4. Cidado, J., Wong, H. Y., Rosen, D. M., Cimino-Mathews, A., Garay, J. P., Fessler, A. G., Rasheed, Z. A., Hicks, J., Cochran, R. L., Croessmann, S., Zabransky, D. J., Mohseni, M., Beaver, J. A., Chu, D., Cravero, K., Christenson, E. S., Medford, A., Mattox, A., De Marzo, A. M., Argani, P., Chawla, A., Hurley, P. J., Lauring, J. and Park, B. H. (2016). Ki-67 is required for maintenance of cancer stem cells but not cell proliferation. Oncotarget 7(5): 6281-6293.
  5. Hurley, P. J., Sundi, D., Shinder, B., Simons, B. W., Hughes, R. M., Miller, R. M., Benzon, B., Faraj, S. F., Netto, G. J., Vergara, I. A., Erho, N., Davicioni, E., Karnes, R. J., Yan, G., Ewing, C., Isaacs, S. D., Berman, D. M., Rider, J. R., Jordahl, K. M., Mucci, L. A., Huang, J., An, S. S., Park, B. H., Isaacs, W. B., Marchionni, L., Ross, A. E. and Schaeffer, E. M. (2016). Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer. Clin Cancer Res 22(2): 448-458.
  6. Wong, H. Y., Wang, G. M., Croessmann, S., Zabransky, D. J., Chu, D., Garay, J. P., Cidado, J., Cochran, R. L., Beaver, J. A., Aggarwal, A., Liu, M. L., Argani, P., Meeker, A., Hurley, P. J., Lauring, J. and Park, B. H. (2015). TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer. Oncotarget 6(42): 44927-44940.
  7. Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Mendonca, J., Sharma, A., Mohseni, M., Rosen, D. M., Scharpf, R. B., Cidado, J., Cochran, R. L., Parsons, H. A., Dalton, W. B., Erlanger, B., Button, B., Cravero, K., Kyker-Snowman, K., Beaver, J. A., Kachhap, S., Hurley, P. J., Lauring, J. and Park, B. H. (2015). NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability. Proc Natl Acad Sci U S A 112(37): 11583-11588.
  8. Chu, D., Paoletti, C., Gersch, C., VanDenBerg, D. A., Zabransky, D. J., Cochran, R. L., Wong, H. Y., Toro, P. V., Cidado, J., Croessmann, S., Erlanger, B., Cravero, K., Kyker-Snowman, K., Button, B., Parsons, H. A., Dalton, W. B., Gillani, R., Medford, A., Aung, K., Tokudome, N., Chinnaiyan, A. M., Schott, A., Robinson, D., Jacks, K. S., Lauring, J., Hurley, P. J., Hayes, D. F., Rae, J. M. and Park, B. H. (2016). ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients. Clin Cancer Res 22(4): 993-999.
  9. Hurley, P. J., Hughes, R. M., Simons, B. W., Huang, J., Miller, R. M., Shinder, B., Haffner, M. C., Esopi, D., Kimura, Y., Jabbari, J., Ross, A. E., Erho, N., Vergara, I. A., Faraj, S. F., Davicioni, E., Netto, G. J., Yegnasubramanian, S., An, S. S. and Schaeffer, E. M. (2015). Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression. Cancer Res 75(20): 4322-4334.
  10. Toro, P. V., Erlanger, B., Beaver, J. A., Cochran, R. L., VanDenBerg, D. A., Yakim, E., Cravero, K., Chu, D., Zabransky, D. J., Wong, H. Y., Croessmann, S., Parsons, H., Hurley, P. J., Lauring, J. and Park, B. H. (2015). Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA. Clin Biochem 48(15): 993-998.
  11. Mohseni, M., Cidado, J., Croessmann, S., Cravero, K., Cimino-Mathews, A., Wong, H. Y., Scharpf, R., Zabransky, D. J., Abukhdeir, A. M., Garay, J. P., Wang, G. M., Beaver, J. A., Cochran, R. L., Blair, B. G., Rosen, D. M., Erlanger, B., Argani, P., Hurley, P. J., Lauring, J. and Park, B. H. (2014). MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers. Proc Natl Acad Sci U S A 111(49): 17606-17611.
  12. Simons, B. W., Durham, N. M., Bruno, T. C., Grosso, J. F., Schaeffer, A. J., Ross, A. E., Hurley, P. J., Berman, D. M., Drake, C. G., Thumbikat, P. and Schaeffer, E. M. (2015). A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression. J Pathol 235(3): 478-489.
  13. Li, J., Ma, W., Wang, P. Y., Hurley, P. J., Bunz, F. and Hwang, P. M. (2014). Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction. Free Radic Biol Med 73: 270-277.
  14. Beaver, J. A., Jelovac, D., Balukrishna, S., Cochran, R. L., Croessmann, S., Zabransky, D. J., Wong, H. Y., Valda Toro, P., Cidado, J., Blair, B. G., Chu, D., Burns, T., Higgins, M. J., Stearns, V., Jacobs, L., Habibi, M., Lange, J., Hurley, P. J., Lauring, J., VanDenBerg, D. A., Kessler, J., Jeter, S., Samuels, M. L., Maar, D., Cope, L., Cimino-Mathews, A., Argani, P., Wolff, A. C. and Park, B. H. (2014). Detection of cancer DNA in plasma of patients with early-stage breast cancer. Clin Cancer Res 20(10): 2643-2650.
  15. Simons, B. W., Hurley, P. J., Huang, Z., Ross, A. E., Miller, R., Marchionni, L., Berman, D. M. and Schaeffer, E. M. (2012). Wnt signaling though beta-catenin is required for prostate lineage specification. Dev Biol 371(2): 246-255.
  16. Hurley, P. J., Marchionni, L., Simons, B. W., Ross, A. E., Peskoe, S. B., Miller, R. M., Erho, N., Vergara, I. A., Ghadessi, M., Huang, Z., Gurel, B., Park, B. H., Davicioni, E., Jenkins, R. B., Platz, E. A., Berman, D. M. and Schaeffer, E. M. (2012). Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome. Proc Natl Acad Sci U S A 109(37): 14977-14982.
  17. Huang, Z., Hurley, P. J., Simons, B. W., Marchionni, L., Berman, D. M., Ross, A. E. and Schaeffer, E. M. (2012). Sox9 is required for prostate development and prostate cancer initiation. Oncotarget 3(6): 651-663.
  18. Ross, A. E., Marchionni, L., Phillips, T. M., Miller, R. M., Hurley, P. J., Simons, B. W., Salmasi, A. H., Schaeffer, A. J., Gearhart, J. P. and Schaeffer, E. M. (2011). Molecular effects of genistein on male urethral development. J Urol 185(5): 1894-1898.
  19. Ross, A. E., Emadi, A., Marchionni, L., Hurley, P. J., Simons, B. W., Schaeffer, E. M. and Vuica-Ross, M. (2011). Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicity. BJU Int 108(3): 447-454.
  20. Hurley, P. J. and Bunz, F. (2007). ATM and ATR: components of an integrated circuit. Cell Cycle 6(4): 414-417.
  21. Hurley, P. J., Wilsker, D. and Bunz, F. (2007). Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation. Oncogene 26(18): 2535-2542.
  22. Matoba, S., Kang, J. G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F. and Hwang, P. M. (2006). p53 regulates mitochondrial respiration. Science 312(5780): 1650-1653.
  23. Topaloglu, O., Hurley, P. J., Yildirim, O., Civin, C. I. and Bunz, F. (2005). Improved methods for the generation of human gene knockout and knockin cell lines. Nucleic Acids Res 33(18): e158.
  24. Boone, D. L., Turer, E. E., Lee, E. G., Ahmad, R. C., Wheeler, M. T., Tsui, C., Hurley, P., Chien, M., Chai, S., Hitotsumatsu, O., McNally, E., Pickart, C. and Ma, A. (2004). The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 5(10): 1052-1060.
  25. Boone, D. L., Lee, E. G., Libby, S., Gibson, P. J., Chien, M., Chan, F., Madonia, M., Burkett, P. R. and Ma, A. (2002). Recent advances in understanding NF-kappaB regulation. Inflamm Bowel Dis 8(3): 201-212.
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