Yaojiong Wu The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, China, China,
1 protocol

Shan Wang School of Life Sciences, Tsinghua University, China, China,
1 protocol

Thomas Cox The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Australia
2 protocols

Chris D. Madsen
  • Department of Laboratory Medicine, Lund University, Sweden
Research focus
  • Cancer biology
  • 3 Author merit


Ph.D. in IFOM-IEO-Campus, Milan, Italy

Current position

Group leader, Faculty of Medicine, Department of Laboratory Medicine, Translational Cancer Research, Lund University, Sweden


  1. Madsen, C. D., Pedersen, J. T., Venning, F. A., Singh, L. B., Moeendarbary, E., Charras, G., Cox, T. R., Sahai, E. and Erler, J. T. (2015). Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis. EMBO Rep 16(10): 1394-1408.
  2. Madsen, C. D., Hooper, S., Tozluoglu, M., Bruckbauer, A., Fletcher, G., Erler, J. T., Bates, P. A., Thompson, B. and Sahai, E. (2015). STRIPAK components determine mode of cancer cell migration and metastasis. Nat Cell Biol 17(1): 68-80.
  3. Ferraris, G. M., Schulte, C., Buttiglione, V., De Lorenzi, V., Piontini, A., Galluzzi, M., Podesta, A., Madsen, C. D. and Sidenius, N. (2014). The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins. EMBO J 33(21): 2458-2472.
  4. Linch, M., Sanz-Garcia, M., Rosse, C., Riou, P., Peel, N., Madsen, C. D., Sahai, E., Downward, J., Khwaja, A., Dillon, C., Roffey, J., Cameron, A. J. and Parker, P. J. (2014). Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis 35(2): 396-406.
  5. Pellegrino, L., Stebbing, J., Braga, V. M., Frampton, A. E., Jacob, J., Buluwela, L., Jiao, L. R., Periyasamy, M., Madsen, C. D., Caley, M. P., Ottaviani, S., Roca-Alonso, L., El-Bahrawy, M., Coombes, R. C., Krell, J. and Castellano, L. (2013). miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts. Nucleic Acids Res 41(10): 5400-5412.
  6. Briones-Orta, M. A., Levy, L., Madsen, C. D., Das, D., Erker, Y., Sahai, E. and Hill, C. S. (2013). Arkadia regulates tumor metastasis by modulation of the TGF-beta pathway. Cancer Res 73(6): 1800-1810.
  7. Madsen, C. D. and Sahai, E. (2010). Cancer dissemination--lessons from leukocytes. Dev Cell 19(1): 13-26.
  8. Cortese, K., Sahores, M., Madsen, C. D., Tacchetti, C. and Blasi, F. (2008). Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR. PLoS One 3(11): e3730.
  9. Madsen, C. D. and Sidenius, N. (2008). The interaction between urokinase receptor and vitronectin in cell adhesion and signalling. Eur J Cell Biol 87(8-9): 617-629.
  10. Caiolfa, V. R., Zamai, M., Malengo, G., Andolfo, A., Madsen, C. D., Sutin, J., Digman, M. A., Gratton, E., Blasi, F. and Sidenius, N. (2007). Monomer dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies. J Cell Biol 179(5): 1067-1082.
  11. Madsen, C. D., Ferraris, G. M., Andolfo, A., Cunningham, O. and Sidenius, N. (2007). uPAR-induced cell adhesion and migration: vitronectin provides the key. J Cell Biol 177(5): 927-939.
  12. Winther, T. N., Madsen, C. D., Pedersen, A. G., von Linstow, M. L., Eugen-Olsen, J. and Hogh, B. (2005). Limited inter- and intra-patient sequence diversity of the genetic lineage A human metapneumovirus fusion gene. Virus Genes 31(1): 89-97.
  13. Boysen, T., Christensen, J. K., Madsen, C. D., Eugen-Olsen, J., Christensen, L. S., Moller-Sorensen, H., Weber, A., Ladefoged, S. D. and Krogsgaard, K. (2003). Presence and significance of TT virus in Danish patients on maintenance hemodialysis. Scand J Urol Nephrol 37(3): 259-264.
  14. Madsen, C. D., Eugen-Olsen, J., Kirk, O., Parner, J., Kaae Christensen, J., Brasholt, M. S., Ole Nielsen, J. and Krogsgaard, K. (2002). TTV viral load as a marker for immune reconstitution after initiation of HAART in HIV-infected patients. HIV Clin Trials 3(4): 287-295.
3 Protocols published
Measurement of Mesenchymal Stem Cells Attachment to Endothelial Cells
Authors:  Shan Wang, Chris D. Madsen and Yaojiong Wu, date: 03/20/2018, view: 6175, Q&A: 1
Mesenchymal stem cells (MSCs) have shown profound therapeutic potential in tissue repair and regeneration. However, recent studies indicate that MSCs are largely entrapped in lungs after intravenous delivery and die shortly. The underlying ...
Relative Stiffness Measurements of Tumour Tissues by Shear Rheology
Authors:  Chris D. Madsen and Thomas R. Cox, date: 05/05/2017, view: 8945, Q&A: 0
The microenvironment of solid tumours is a critical contributor to the progression of tumours and offers a promising target for therapeutic intervention (Cox and Erler, 2011; Barker et al., 2012; Cox et al., 2016; Cox and Erler, ...
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