Chris D. Madsen
  • Department of Laboratory Medicine, Lund University, Sweden
Research focus
  • Cancer biology
Personal information


Ph.D. in IFOM-IEO-Campus, Milan, Italy

Current position

Group leader, Faculty of Medicine, Department of Laboratory Medicine, Translational Cancer Research, Lund University, Sweden


  1. Madsen, C. D., Pedersen, J. T., Venning, F. A., Singh, L. B., Moeendarbary, E., Charras, G., Cox, T. R., Sahai, E. and Erler, J. T. (2015). Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis. EMBO Rep 16(10): 1394-1408.
  2. Madsen, C. D., Hooper, S., Tozluoglu, M., Bruckbauer, A., Fletcher, G., Erler, J. T., Bates, P. A., Thompson, B. and Sahai, E. (2015). STRIPAK components determine mode of cancer cell migration and metastasis. Nat Cell Biol 17(1): 68-80.
  3. Ferraris, G. M., Schulte, C., Buttiglione, V., De Lorenzi, V., Piontini, A., Galluzzi, M., Podesta, A., Madsen, C. D. and Sidenius, N. (2014). The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins. EMBO J 33(21): 2458-2472.
  4. Linch, M., Sanz-Garcia, M., Rosse, C., Riou, P., Peel, N., Madsen, C. D., Sahai, E., Downward, J., Khwaja, A., Dillon, C., Roffey, J., Cameron, A. J. and Parker, P. J. (2014). Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis 35(2): 396-406.
  5. Pellegrino, L., Stebbing, J., Braga, V. M., Frampton, A. E., Jacob, J., Buluwela, L., Jiao, L. R., Periyasamy, M., Madsen, C. D., Caley, M. P., Ottaviani, S., Roca-Alonso, L., El-Bahrawy, M., Coombes, R. C., Krell, J. and Castellano, L. (2013). miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts. Nucleic Acids Res 41(10): 5400-5412.
  6. Briones-Orta, M. A., Levy, L., Madsen, C. D., Das, D., Erker, Y., Sahai, E. and Hill, C. S. (2013). Arkadia regulates tumor metastasis by modulation of the TGF-beta pathway. Cancer Res 73(6): 1800-1810.
  7. Madsen, C. D. and Sahai, E. (2010). Cancer dissemination--lessons from leukocytes. Dev Cell 19(1): 13-26.
  8. Cortese, K., Sahores, M., Madsen, C. D., Tacchetti, C. and Blasi, F. (2008). Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR. PLoS One 3(11): e3730.
  9. Madsen, C. D. and Sidenius, N. (2008). The interaction between urokinase receptor and vitronectin in cell adhesion and signalling. Eur J Cell Biol 87(8-9): 617-629.
  10. Caiolfa, V. R., Zamai, M., Malengo, G., Andolfo, A., Madsen, C. D., Sutin, J., Digman, M. A., Gratton, E., Blasi, F. and Sidenius, N. (2007). Monomer dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies. J Cell Biol 179(5): 1067-1082.
  11. Madsen, C. D., Ferraris, G. M., Andolfo, A., Cunningham, O. and Sidenius, N. (2007). uPAR-induced cell adhesion and migration: vitronectin provides the key. J Cell Biol 177(5): 927-939.
  12. Winther, T. N., Madsen, C. D., Pedersen, A. G., von Linstow, M. L., Eugen-Olsen, J. and Hogh, B. (2005). Limited inter- and intra-patient sequence diversity of the genetic lineage A human metapneumovirus fusion gene. Virus Genes 31(1): 89-97.
  13. Boysen, T., Christensen, J. K., Madsen, C. D., Eugen-Olsen, J., Christensen, L. S., Moller-Sorensen, H., Weber, A., Ladefoged, S. D. and Krogsgaard, K. (2003). Presence and significance of TT virus in Danish patients on maintenance hemodialysis. Scand J Urol Nephrol 37(3): 259-264.
  14. Madsen, C. D., Eugen-Olsen, J., Kirk, O., Parner, J., Kaae Christensen, J., Brasholt, M. S., Ole Nielsen, J. and Krogsgaard, K. (2002). TTV viral load as a marker for immune reconstitution after initiation of HAART in HIV-infected patients. HIV Clin Trials 3(4): 287-295.
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