Oliver Mortusewicz
  • Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Sweden
Research focus
  • Cancer biology
Personal information


Ph.D in Biology, LMU Biocenter, Anthropology and Human Genetics, Department of Biology II, Ludwig Maximilians University Munich, Germany

Current Position

Team and Prohect leader in the Helleday Laboratory Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Sweden


  1. Sanjiv, K., Hagenkort, A., Calderon-Montano, J. M., Koolmeister, T., Reaper, P. M., Mortusewicz, O., Jacques, S. A., Kuiper, R. V., Schultz, N., Scobie, M., Charlton, P. A., Pollard, J. R., Berglund, U. W., Altun, M. and Helleday, T. (2016). Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities. Cell Rep 14(2): 298-309.
  2. Xie, S., Mortusewicz, O., Ma, H. T., Herr, P., Poon, R. Y., Helleday, T. and Qian, C. (2015). Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. Mol Cell 60(1): 163-176.
  3. Herr, P., Lundin, C., Evers, B., Ebner, D., Bauerschmidt, C., Kingham, G., Palmai-Pallag, T., Mortusewicz, O., Frings, O., Sonnhammer, E. and Helleday, T. (2015). A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discovery 1.
  4. Rajan, M., Mortusewicz, O., Rothbauer, U., Hastert, F. D., Schmidthals, K., Rapp, A., Leonhardt, H. and Cardoso, M. C. (2015). Generation of an alpaca-derived nanobody recognizing gamma-H2AX. FEBS Open Bio 5: 779-788.
  5. Ying, S., Chen, Z., Medhurst, A. L., Neal, J. A., Bao, Z., Mortusewicz, O., McGouran, J., Song, X., Shen, H., Hamdy, F. C., Kessler, B. M., Meek, K. and Helleday, T. (2016). DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair. Cancer Res 76(5): 1078-1088.
  6. Mortusewicz, O., Evers, B. and Helleday, T. (2016). PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites. Oncogene 35(6): 761-770.
  7. Mortusewicz, O., Herr, P. and Helleday, T. (2013). Early replication fragile sites: where replication-transcription collisions cause genetic instability. EMBO J 32(4): 493-495.
  8. Jones, R. M., Mortusewicz, O., Afzal, I., Lorvellec, M., Garcia, P., Helleday, T. and Petermann, E. (2013). Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress. Oncogene 32(32): 3744-3753.
  9. Strom, C. E., Mortusewicz, O., Finch, D., Parsons, J. L., Lagerqvist, A., Johansson, F., Schultz, N., Erixon, K., Dianov, G. L. and Helleday, T. (2011). CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair. DNA Repair (Amst) 10(9): 961-969.
  10. Sanchez-Molina, S., Mortusewicz, O., Bieber, B., Auer, S., Eckey, M., Leonhardt, H., Friedl, A. A. and Becker, P. B. (2011). Role for hACF1 in the G2/M damage checkpoint. Nucleic Acids Res.
  11. Mortusewicz, O., Fouquerel, E. Ame, J. C., Leonhardt, H. and Schreiber, V. (2011). PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms. Nucleic Acids Res.

  12. Boehler, C., Gauthier, L. R., Mortusewicz, O., Biard, D. S., Saliou, J. M., Bresson, A., Sanglier-Cianferani, S., Smith, S., Schreiber, V., Boussin, F. and Dantzer, F. (2011). Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc Natl Acad Sci U S A 108(7): 2783-2788.

  13. Ruzov, A., Shorning, B., Mortusewicz, O., Dunican, D. S., Leonhardt, H. and Meehan, R. R. (2009). MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos. Development 136(13): 2277-2286.

  14. Zolghadr, K., Mortusewicz, O., Rothbauer, U., Kleinhans, R., Goehler, H., Wanker, E. E., Cardoso, M. C. and Leonhardt, H. (2008). A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells. Mol Cell Proteomics 7(11): 2279-2287.

  15. Mortusewicz, O., Leonhardt, H. and Cardoso, M. C. (2008). Spatiotemporal dynamics of regulatory protein recruitment at DNA damage sites. J Cell Biochem 104(5): 1562-1569.

  16. Mortusewicz, O., Ame, J. C., Schreiber, V. and Leonhardt, H. (2007). Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells. Nucleic Acids Res 35(22): 7665-7675.

  17. Mortusewicz, O. and Leonhardt, H. (2007). XRCC1 and PCNA are loading platforms with distinct kinetic properties and different capacities to respond to multiple DNA lesions. BMC Mol Biol 8: 81.

  18. Mortusewicz, O., Rothbauer, U., Cardoso, M. C. and Leonhardt, H. (2006). Differential recruitment of DNA Ligase I and III to DNA repair sites. Nucleic Acids Res 34(12): 3523-3532.

  19. Chea, J., Zhang, S., Zhao, H., Zhang, Z., Lee, E. Y., Darzynkiewicz, Z. and Lee, M. Y. (2012). Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage. Cell Cycle 11(15): 2885-2895.

  20. Mortusewicz, O., Schermelleh, L., Walter, J., Cardoso, M. C. and Leonhardt, H. (2005). Recruitment of DNA methyltransferase I to DNA repair sites. Proc Natl Acad Sci U S A 102(25): 8905-8909.

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