Education
Ph.D in Biochemistry, Departement of Medical Sciences, University of Udine, 2000
Current Position
Professor in Biochemistry, Department of Life Sciences, University of Trieste, Italy
Publications (since 2007)
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Xhindoli, D., Pacor, S., Benincasa, M., Scocchi, M., Gennaro, R. and Tossi, A. (2016). The human cathelicidin LL-37--A pore-forming antibacterial peptide and host-cell modulator. Biochim Biophys Acta 1858(3): 546-566.
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Seefeldt, A. C., Graf, M., Perebaskine, N., Nguyen, F., Arenz, S., Mardirossian, M., Scocchi, M., Wilson, D. N. and Innis, C. A. (2016). Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome. Nucleic Acids Res 44: 2429-2438.
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Scocchi, M., Mardirossian, M., Runti, G. and Benincasa, M. (2016). Non-Membrane Permeabilizing Modes of Action of Antimicrobial Peptides on Bacteria. Curr Top Med Chem 16(1): 76-88.
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Paulsen, V. S., Mardirossian, M., Blencke, H. M., Benincasa, M., Runti, G., Nepa, M., Haug, T., Stensvag, K. and Scocchi, M. (2016). Inner membrane proteins YgdD and SbmA are required for the complete susceptibility of E. coli to the proline-rich antimicrobial peptide arasin 1(1-25). Microbiology.
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Mardirossian, M., Pompilio, A., Crocetta, V., De Nicola, S., Guida, F., Degasperi, M., Gennaro, R., Di Bonaventura, G. and Scocchi, M. (2016). In vitro and in vivo evaluation of BMAP-derived peptides for the treatment of cystic fibrosis-related pulmonary infections. Amino Acids 48(9): 2253-2260.
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Guida, F., Benincasa, M., Zahariev, S., Scocchi, M., Berti, F., Gennaro, R. and Tossi, A. (2015). Effect of size and N-terminal residue characteristics on bacterial cell penetration and antibacterial activity of the proline-rich peptide Bac7. J Med Chem 58(3): 1195-1204.
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Bociek, K., Ferluga, S., Mardirossian, M., Benincasa, M., Tossi, A., Gennaro, R. and Scocchi, M. (2015). Lipopolysaccharide Phosphorylation by the WaaY Kinase Affects the Susceptibility of Escherichia coli to the Human Antimicrobial Peptide LL-37. J Biol Chem 290(32): 19933-19941.
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Benincasa, M., Zahariev, S., Pelillo, C., Milan, A., Gennaro, R. and Scocchi, M. (2015). PEGylation of the peptide Bac7(1-35) reduces renal clearance while retaining antibacterial activity and bacterial cell penetration capacity. Eur J Med Chem 95: 210-219.
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Pelillo, C., Benincasa, M., Scocchi, M., Gennaro, R., Tossi, A. and Pacor, S. (2014). Cellular internalization and cytotoxicity of the antimicrobial proline-rich peptide Bac7(1-35) in monocytes/macrophages, and its activity against phagocytosed Salmonella typhimurium. Protein Pept Lett 21(4): 382-390.
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Mattiuzzo, M., De Gobba, C., Runti, G., Mardirossian, M., Bandiera, A., Gennaro, R. and Scocchi, M. (2014). Proteolytic activity of Escherichia coli oligopeptidase B against proline-rich antimicrobial peptides. J Microbiol Biotechnol 24(2): 160-167.
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Mardirossian, M., Grzela, R., Giglione, C., Meinnel, T., Gennaro, R., Mergaert, P. and Scocchi, M. (2014). The host antimicrobial peptide Bac71-35 binds to bacterial ribosomal proteins and inhibits protein synthesis. Chem Biol 21(12): 1639-1647.
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Arnold, M. F., Caro-Hernandez, P., Tan, K., Runti, G., Wehmeier, S., Scocchi, M., Doerrler, W. T., Walker, G. C. and Ferguson, G. P. (2014). Enteric YaiW is a surface-exposed outer membrane lipoprotein that affects sensitivity to an antimicrobial peptide. J Bacteriol 196(2): 436-444.
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Runti, G., Lopez Ruiz Mdel, C., Stoilova, T., Hussain, R., Jennions, M., Choudhury, H. G., Benincasa, M., Gennaro, R., Beis, K. and Scocchi, M. (2013). Functional characterization of SbmA, a bacterial inner membrane transporter required for importing the antimicrobial peptide Bac7(1-35). J Bacteriol 195(23): 5343-5351.
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Paulsen, V. S., Blencke, H. M., Benincasa, M., Haug, T., Eksteen, J. J., Styrvold, O. B., Scocchi, M. and Stensvag, K. (2013). Structure-activity relationships of the antimicrobial peptide arasin 1 - and mode of action studies of the N-terminal, proline-rich region. PLoS One 8(1): e53326.
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Corbalan, N., Runti, G., Adler, C., Covaceuszach, S., Ford, R. C., Lamba, D., Beis, K., Scocchi, M. and Vincent, P. A. (2013). Functional and structural study of the dimeric inner membrane protein SbmA. J Bacteriol 195(23): 5352-5361.
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Arnold, M. F., Haag, A. F., Capewell, S., Boshoff, H. I., James, E. K., McDonald, R., Mair, I., Mitchell, A. M., Kerscher, B., Mitchell, T. J., Mergaert, P., Barry, C. E., 3rd, Scocchi, M., Zanda, M., Campopiano, D. J. and Ferguson, G. P. (2013). Partial complementation of Sinorhizobium meliloti bacA mutant phenotypes by the Mycobacterium tuberculosis BacA protein. J Bacteriol 195(2): 389-398.
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Tossi, A., Scocchi, M., Zahariev, S. and Gennaro, R. (2012). Use of unnatural amino acids to probe structure-activity relationships and mode-of-action of antimicrobial peptides. Methods Mol Biol 794: 169-183.
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Pompilio, A., Crocetta, V., Scocchi, M., Pomponio, S., Di Vincenzo, V., Mardirossian, M., Gherardi, G., Fiscarelli, E., Dicuonzo, G., Gennaro, R. and Di Bonaventura, G. (2012). Potential novel therapeutic strategies in cystic fibrosis: antimicrobial and anti-biofilm activity of natural and designed alpha-helical peptides against Staphylococcus aureus, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. BMC Microbiol 12: 145.
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Scocchi, M., Tossi, A. and Gennaro, R. (2011). Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action. Cell Mol Life Sci 68(13): 2317-2330.
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Pompilio, A., Scocchi, M., Pomponio, S., Guida, F., Di Primio, A., Fiscarelli, E., Gennaro, R. and Di Bonaventura, G. (2011). Antibacterial and anti-biofilm effects of cathelicidin peptides against pathogens isolated from cystic fibrosis patients. Peptides 32(9): 1807-1814.
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Wehmeier, S., Arnold, M. F., Marlow, V. L., Aouida, M., Myka, K. K., Fletcher, V., Benincasa, M., Scocchi, M., Ramotar, D. and Ferguson, G. P. (2010). Internalization of a thiazole-modified peptide in Sinorhizobium meliloti occurs by BacA-dependent and -independent mechanisms. Microbiology 156(Pt 9): 2702-2713.
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Tomasinsig, L., Benincasa, M., Scocchi, M., Skerlavaj, B., Tossi, A., Zanetti, M. and Gennaro, R. (2010). Role of Cathelicidin Peptides in Bovine Host Defense and Healing. Probiotics Antimicrob Proteins 2(1): 12-20.
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Padovan, L., Scocchi, M. and Tossi, A. (2010). Structural aspects of plant antimicrobial peptides. Curr Protein Pept Sci 11(3): 210-219.
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Karunakaran, R., Haag, A. F., East, A. K., Ramachandran, V. K., Prell, J., James, E. K., Scocchi, M., Ferguson, G. P. and Poole, P. S. (2010). BacA is essential for bacteroid development in nodules of galegoid, but not phaseoloid, legumes. J Bacteriol 192(11): 2920-2928.
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Benincasa, M., Pelillo, C., Zorzet, S., Garrovo, C., Biffi, S., Gennaro, R. and Scocchi, M. (2010). The proline-rich peptide Bac7(1-35) reduces mortality from Salmonella typhimurium in a mouse model of infection. BMC Microbiol 10: 178.
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Scocchi, M., Pallavicini, A., Salgaro, R., Bociek, K. and Gennaro, R. (2009). The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains. Comp Biochem Physiol B Biochem Mol Biol 152(4): 376-381.
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Marlow, V. L., Haag, A. F., Kobayashi, H., Fletcher, V., Scocchi, M., Walker, G. C. and Ferguson, G. P. (2009). Essential role for the BacA protein in the uptake of a truncated eukaryotic peptide in Sinorhizobium meliloti. J Bacteriol 191(5): 1519-1527.
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Benincasa, M., Pacor, S., Gennaro, R. and Scocchi, M. (2009). Rapid and reliable detection of antimicrobial peptide penetration into gram-negative bacteria based on fluorescence quenching. Antimicrob Agents Chemother 53(8): 3501-3504.
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Scocchi, M., Mattiuzzo, M., Benincasa, M., Antcheva, N., Tossi, A. and Gennaro, R. (2008). Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach: a tool to identify new bacterial targets amenable to the design of novel antibiotics. Methods Mol Biol 494: 161-176.
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Mattiuzzo, M., Bandiera, A., Gennaro, R., Benincasa, M., Pacor, S., Antcheva, N. and Scocchi, M. (2007). Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides. Mol Microbiol 66(1): 151-163.