Education
Ph.D in Biology (Biochemistry), Institut de Biotecnologia i de Biomedicina. Universitat Autònoma de Barcelona, 2001
Current Position
Associate Professor in Biochemistry, Molecular Biology, Biomedicine and Nanotechnology. Universitat Autònoma de Barcelona, Barcelona. Spain
Publications (since 2012)
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Lorenzo, J. and Montana, A. M. (2016). The molecular shape and the field similarities as criteria to interpret SAR studies for fragment-based design of platinum(IV) anticancer agents. Correlation of physicochemical properties with cytotoxicity. J Mol Graph Model 69: 39-60.
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Arinez-Soriano, J., Albalad, J., Carne-Sanchez, A., Bonnet, C. S., Busque, F., Lorenzo, J., Juanhuix, J., Terban, M. W., Imaz, I., Toth, E. and Maspoch, D. (2016). pH-Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate. Chemistry 22(37): 13162-13170.
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Contreras Rodríguez, A. R., Saiz-Poseu, J., García-Pardo, J., García, B., Lorenzo, J., Ojea-Jiménez, I., Komilis, D., Sedó, J., Busqué, F., Sánchez, A., Ruiz-Molina, D. and Font, X. (2016). Biocompatible polydopamine-like particles for the removal of heavy metals at extremely low concentrations. RSC Adv 6: 40058-40066.
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Lufrano, D., Cotabarren, J., Garcia-Pardo, J., Fernandez-Alvarez, R., Tort, O., Tanco, S., Aviles, F. X., Lorenzo, J. and Obregon, W. D. (2015). Biochemical characterization of a novel carboxypeptidase inhibitor from a variety of Andean potatoes. Phytochemistry 120: 36-45.
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Borges, M., Yu, S., Laromaine, A., Roig, A., Suárez-García, S., Lorenzo, J., Ruiz-Molina, D. and Novio, F. (2015). Dual T1/T2 MRI contrast agent based on hybrid SPION@coordination polymer nanoparticles. RSC Adv 5: 86779–86783.
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Miserachs, H. G., Cipriani, M., Grau, J., Vilaseca, M., Lorenzo, J., Medeiros, A., Comini, M. A., Gambino, D., Otero, L. and Moreno, V. (2015). Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands. J Inorg Biochem 150: 38-47.
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Fait, M. E., Garrote, G. L., Clapes, P., Tanco, S., Lorenzo, J. and Morcelle, S. R. (2015). Biocatalytic synthesis, antimicrobial properties and toxicity studies of arginine derivative surfactants. Amino Acids 47(7): 1465-1477.
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Correia, I., Roy, S., Matos, C. P., Borovic, S., Butenko, N., Cavaco, I., Marques, F., Lorenzo, J., Rodriguez, A., Moreno, V. and Pessoa, J. C. (2015). Vanadium(IV) and copper(II) complexes of salicylaldimines and aromatic heterocycles: Cytotoxicity, DNA binding and DNA cleavage properties. J Inorg Biochem 147: 134-146.
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Ruyra, A., Yazdi, A., Espin, J., Carne-Sanchez, A., Roher, N., Lorenzo, J., Imaz, I. and Maspoch, D. (2015). Synthesis, culture medium stability, and in vitro and in vivo zebrafish embryo toxicity of metal-organic framework nanoparticles. Chemistry 21(6): 2508-2518.
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Tanco, S., Tort, O., Demol, H., Aviles, F. X., Gevaert, K., Van Damme, P. and Lorenzo, J. (2015). C-terminomics screen for natural substrates of cytosolic carboxypeptidase 1 reveals processing of acidic protein C termini. Mol Cell Proteomics 14(1): 177-190.
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Garcia-Pardo, J., Grana-Montes, R., Fernandez-Mendez, M., Ruyra, A., Roher, N., Aviles, F. X., Lorenzo, J. and Ventura, S. (2014). Amyloid formation by human carboxypeptidase D transthyretin-like domain under physiological conditions. J Biol Chem 289(49): 33783-33796.
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Novio, F., Lorenzo, J., Nador, F., Wnuk, K. and Ruiz-Molina, D. (2014). Group (-CO2H) functionalized coordination polymer nanoparticles as efficient platforms for drug delivery. Chemistry A 20(47): 15443-15450.
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Tort, O., Tanco, S., Rocha, C., Bieche, I., Seixas, C., Bosc, C., Andrieux, A., Moutin, M. J., Aviles, F. X., Lorenzo, J. and Janke, C. (2014). The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Mol Biol Cell 25(19): 3017-3027.
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Lorenzo, J., Delgado, A., Montana, A. M., Mesas, J. M., Alegre, M. T., Rodriguez Mdel, C. and Aviles, F. X. (2014). Synthesis, biological evaluation and SAR studies of novel bicyclic antitumor platinum(IV) complexes. Eur J Med Chem 83: 374-388.
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Nunez, C., Oliveira, E., Garcia-Pardo, J., Diniz, M., Lorenzo, J., Capelo, J. L. and Lodeiro, C. (2014). A novel quinoline molecular probe and the derived functionalized gold nanoparticles: sensing properties and cytotoxicity studies in MCF-7 human breast cancer cells. J Inorg Biochem 137: 115-122.
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Duran, M., Salas, E., Cano, L. M., Moneriz, C. E., Mendez, D. M., Lorenzo, J., Piermattey, J., Montalvo, J., Bautista Jose, M. and Gaitan, R. (2014). Quinoid Compounds Cause Inhibition of Falcipain 2, and Arrest Plasmodium falciparum Growth in Vitro. Lat Am J Pharm 33(4): 666-674.
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Saez, R., Lorenzo, J., Prieto, M. J., Font-Bardia, M., Calvet, T., Omenaca, N., Vilaseca, M. and Moreno, V. (2014). Influence of PPh(3) moiety in the anticancer activity of new organometallic ruthenium complexes. J Inorg Biochem 136: 1-12.
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Valente, A., Santos, A. M., Côrte-Real, L., Robalo, M. P., Moreno, V., Font-Bardia, M., Calvet, T., Lorenzo, J., Garcia, M. H. (2014). New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leukemia cancer cells. J Organomet Chem 756: 52-60.
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Oliveira, E., Santos, H. M., Garcia-Pardo, J., Diniz, M., Lorenzo, J., Rodriguez-Gonzalez, B., Capelo, J. L. and Lodeiro, C. (2013). Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells. Front Chem 1: 29.
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Carne-Sanchez, A., Bonnet, C. S., Imaz, I., Lorenzo, J., Toth, E. and Maspoch, D. (2013). Relaxometry studies of a highly stable nanoscale metal-organic framework made of Cu(II), Gd(III), and the macrocyclic DOTP. J Am Chem Soc 135(47): 17711-17714.
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Tanco, S., Lorenzo, J., Garcia-Pardo, J., Degroeve, S., Martens, L., Aviles, F. X., Gevaert, K. and Van Damme, P. (2013). Proteome-derived peptide libraries to study the substrate specificity profiles of carboxypeptidases. Mol Cell Proteomics 12(8): 2096-2110.
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Demoro, B., de Almeida, R. F., Marques, F., Matos, C. P., Otero, L., Costa Pessoa, J., Santos, I., Rodriguez, A., Moreno, V., Lorenzo, J., Gambino, D. and Tomaz, A. I. (2013). Screening organometallic binuclear thiosemicarbazone ruthenium complexes as potential anti-tumour agents: cytotoxic activity and human serum albumin binding mechanism. Dalton Trans 42(19): 7131-7146.
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Escribano, E., Font-Bardia, M., Calvet, T., Lorenzo, J., Gamez, P. and Moreno, V. (2013). DNA Binding Studies of a Series of cis-[Pt(Am)2X2] Complexes (Am = inert amine, X = labile carboxylato ligand). Inorg Chim Acta 394: 65-77.
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Rodriguez de la Vega Otazo, M., Lorenzo, J., Tort, O., Aviles, F. X. and Bautista, J. M. (2013). Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). FASEB J 27(2): 424-431.
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Aznar, R., Grabulosa, A., Mannu, A., Muller, G., Sainz, D., Moreno, V., Font-Bardia, M., Calvet, T. and Lorenzo, J. (2012). [RuCl2(η6‑p‑cymene)(P*)] and [RuCl2(κ-P*‑η6‑arene)] Complexes Containing P-Stereogenic Phosphines. Activity in Transfer Hydrogenation and Interactions with DNA. Organometallics 32(8): 2344-2362.
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Lin, V. S. and Chang, C. J. (2012). Fluorescent probes for sensing and imaging biological hydrogen sulfide. Curr Opin Chem Biol 16(5-6): 595-601.
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Ojea-Jiménez, I., Lorenzo, J., Rebled, J., Sendra, J., Arbiol, J. and Puntes, V. (2012). Synthesis of Co-organosilane-Au nanocomposites via a controlled interphasic reduction. Chemistry of Materials 24(21): 4019-4027.
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Ojea-Jimenez, I., Tort, O., Lorenzo, J. and Puntes, V. F. (2012). Engineered nonviral nanocarriers for intracellular gene delivery applications. Biomed Mater 7(5): 054106.
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Ojea-Jimenez, I., Garcia-Fernandez, L., Lorenzo, J. and Puntes, V. F. (2012). Facile preparation of cationic gold nanoparticle-bioconjugates for cell penetration and nuclear targeting. ACS Nano 6(9): 7692-7702.
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Otero, A., Rodriguez de la Vega, M., Tanco, S., Lorenzo, J., Aviles, F. X. and Reverter, D. (2012). The novel structure of a cytosolic M14 metallocarboxypeptidase (CCP) from Pseudomonas aeruginosa: a model for mammalian CCPs. FASEB J 26(9): 3754-3764.