Houjian Cai
  • University of Georgia
Research fields
  • Cancer biology
Personal information


Ph.D. in Microbiology, University of Tennessee, Knoxville (UTK),  2006        

Current Position

Assistant Professor, Department of Pharmaceutical & Biomedical Sciences, University of Georgia, Athens, USA


  1. Di Sebastiano, K. M. and Mourtzakis, M. (2014). The role of dietary fat throughout the prostate cancer trajectory. Nutrients 6(12): 6095-6109.
  2. Wu, M., Ingram, L., Tolosa, E. J., Vera, R. E., Li, Q., Kim, S., Ma, Y., Spyropoulos, D. D., Beharry, Z., Huang, J., Fernandez-Zapico, M. E. and Cai, H. (2016). Gli transcription factors mediate the oncogenic transformation of prostate basal cells induced by a Kras-androgen receptor axis. J Biol Chem.
  3. Coe, G. L., Redd, P. S., Paschall, A. V., Lu, C., Gu, L., Cai, H., Albers, T., Lebedyeva, I. O. and Liu, K. (2016). Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes. Sci Rep 6: 30816.
  4. Alsaggar, M., Yao, Q., Cai, H. and Liu, D. (2016). Differential growth and responsiveness to cancer therapy of tumor cells in different environments. Clin Exp Metastasis 33(2): 115-124.
  5. Verweij, F. J., de Heus, C., Kroeze, S., Cai, H., Kieff, E., Piersma, S. R., Jimenez, C. R., Middeldorp, J. M. and Pegtel, D. M. (2015). Exosomal sorting of the viral oncoprotein LMP1 is restrained by TRAF2 association at signalling endosomes. J Extracell Vesicles 4: 26334.
  6. Venkata, J. K., An, N., Stuart, R., Costa, L. J., Cai, H., Coker, W., Song, J. H., Gibbs, K., Matson, T., Garrett-Mayer, E., Wan, Z., Ogretmen, B., Smith, C. and Kang, Y. (2014). Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. Blood 124(12): 1915-1925.
  7. Cai, H., Memarzadeh, S., Stoyanova, T., Beharry, Z., Kraft, A. S. and Witte, O. N. (2012). Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer. Cancer Res 72(18): 4672-4681.
  8. Cai, H., Smith, D. A., Memarzadeh, S., Lowell, C. A., Cooper, J. A. and Witte, O. N. (2011). Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A 108(16): 6579-6584.
  9. Cai, H., Babic, I., Wei, X., Huang, J. and Witte, O. N. (2011). Invasive prostate carcinoma driven by c-Src and androgen receptor synergy. Cancer Res 71(3): 862-872.
  10. Stoyanova, T., Goldstein, A. S., Cai, H., Drake, J. M., Huang, J. and Witte, O. N. (2012). Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via beta-catenin signaling. Genes Dev 26(20): 2271-2285.
  11. Mulholland, D. J., Tran, L. M., Li, Y., Cai, H., Morim, A., Wang, S., Plaisier, S., Garraway, I. P., Huang, J., Graeber, T. G. and Wu, H. (2011). Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 19(6): 792-804.
  12. Drake, J. M., Graham, N. A., Stoyanova, T., Sedghi, A., Goldstein, A. S., Cai, H., Smith, D. A., Zhang, H., Komisopoulou, E., Huang, J., Graeber, T. G. and Witte, O. N. (2012). Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A 109(5): 1643-1648.
  13. Memarzadeh, S., Cai, H., Janzen, D. M., Xin, L., Lukacs, R., Riedinger, M., Zong, Y., DeGendt, K., Verhoeven, G., Huang, J. and Witte, O. N. (2011). Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal. Proc Natl Acad Sci U S A 108(19): 7962-7967.
  14. Cai, H., Hauser, M., Naider, F. and Becker, J. M. (2007). Differential regulation and substrate preferences in two peptide transporters of Saccharomyces cerevisiae. Eukaryot Cell 6(10): 1805-1813.
  15. Wiles, A. M., Cai, H., Naider, F. and Becker, J. M. (2006). Nutrient regulation of oligopeptide transport in Saccharomyces cerevisiae. Microbiology 152(Pt 10): 3133-3145.
  16. Cai, H., Kauffman, S., Naider, F. and Becker, J. M. (2006). Genome-wide screen reveals a wide regulatory network for di/tri-peptide utilization in Saccharomyces cerevisiae. Genetics 172(3): 1459-1476.
  17. Homann, O. R., Cai, H., Becker, J. M. and Lindquist, S. L. (2005). Harnessing natural diversity to probe metabolic pathways. PLoS Genet 1(6): e80.
  18. Cai, H., Zarda, B., Mattison, G., Schonholzer, F. and Hahn, D. (2002). Fate of protozoa transiting the digestive tract of the earthwarm lumbricus terrestris L. Pedobiologia 46, 161-175.
  19. Liu, L., Gu, Y., Luo, Y., Ma, W., Zhou, Z. and Cai, H. (2000). On the Growth and Phosphorous Metabolism of Bacterium Isolated from Microcystis aeruginosu in Taihu Lake. J Lake Sci 12(4): 373-378.
  20. Gu, Y., Luo, Y., Ma, W., Zhou, Z. and Cai, H. (2000). Effects of Temperature, Organic Carbon, Nitrogen and Phosphate on the Growth of Bacillus sp. Isolated from Microcystis aeruginosa. Chinese Journal of Applied and Environmental Biology 6(1): 86-89.
  21. Zhou, Z., Luo, Y., Ma, W. and Cai, H. (1998). Identification and determination of growth curve of four bacterium isolated from Taihu Lake. J Lake Sci 10(4):60-62.
  22. Cai, H. (1998). The response of ciliated protozoans to eutrophication in Meiliang Bay of Taihu Lake. J Lake Sci 10(3): 43-48.
  23. McNaught, D. C., Chen, W. and Cai, H. J. (1997). Grazing on a Microcystis bloom by cladocerans and copepods in Tai Lake. Verhal. Internat Verein Limnol 26: 550-552.
  24. Gao, X., Chen, Y. and Cai, H. (1997). Analyses of aquatic environment characteristics and tendency of eutrophication in Meiliang Bay and the main waterbody in Taihu Lake. In: Cai, Q. (Ed). The Ecological Research on Taihu Lake, Meteorologic Press (Beijing) pp 19-29.
  25. Chen, W. and Cai, H. (1996). Study on the aerobic decomposition of Microcystis in Taihu Lake. J Lake Sci 8: 248-252.
  26. Cai, H., Zhou, F., Jin, Q., Chen, Z., Yu, A., Jin H., Huang, H. (1994). Study of PP333 Toxicity to several aquatic organisms and effects on plant ultramicrostructure. J Nanjing Univ 30: 274-280.
  27. Cai, H. and Zhou, F. (1994). Bioconcentration and elimination of PP333 in Daphnia magna. Rural Ecoenviron 10: 33-35.
  28. Cai, H., Chen Y., Cai Q. and Gao X. (1994). Relation between primary production of phytoplankton and relative factors at the mouth of Meiliang Bay in Lake Taihu. J Lake Sci 6: 340-3477.
  29. Zhou, F., Cai, H., Jin, Q., Cai, Q. and Wang X. (1994). Study on absorption of PP333 in soil and distribution dynamics in model ecosystems. J Nanjing Univ 30: 455-462.
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