Education

M.D in University of Missouri, Columbia, Missouri, 1992

Current Position

Staff Physician, Birmingham Veterans Administration Medical Center
Professor, Medicine, Pulmonary, Allergy, and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama
Scientific Director, Interstitial Lung Disease Program, University of Alabama at Birmingham, Birmingham, Alabama
Endowed Professorship in Lung Biology, University of Alabama at Birmingham

Publications (since 2005)

1. Larson-Casey, J. L., Deshane, J. S., Ryan, A. J., Thannickal, V. J. and Carter, A. B. (2016). Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Immunity 44(3): 582-596.
2. Larson-Casey, J. L., Deshane, J. S., Ryan, A. J., Thannickal, V. J. and Carter, A. B. (2016). Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Immunity 44(3): 582-596.
3. He, C. and Carter, A. B. (2015). The Metabolic Prospective and Redox Regulation of Macrophage Polarization. J Clin Cell Immunol 6(6).
4. Winters, C. J., Koval, O., Murthy, S., Allamargot, C., Sebag, S. C., Paschke, J. D., Jaffer, O. A., Carter, A. B. and Grumbach, I. M. (2016). CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis. Am J Physiol Lung Cell Mol Physiol 310(1): L86-94.
5. Surolia, R., Karki, S., Kim, H., Yu, Z., Kulkarni, T., Mirov, S. B., Carter, A. B., Rowe, S. M., Matalon, S., Thannickal, V. J., Agarwal, A. and Antony, V. B. (2015). Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice. Am J Physiol Lung Cell Mol Physiol 309(3): L280-292.
6. Osborn-Heaford, H. L., Murthy, S., Gu, L., Larson-Casey, J. L., Ryan, A. J., Shi, L., Glogauer, M., Neighbors, J. D., Hohl, R. and Brent Carter, A. (2015). Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis. Free Radic Biol Med 86: 47-56.
7. Murthy, S., Larson-Casey, J. L., Ryan, A. J., He, C., Kobzik, L. and Carter, A. B. (2015). Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure. FASEB J 29(8): 3527-3536.
8. Larson-Casey, J. L., Murthy, S., Ryan, A. J. and Carter, A. B. (2014). Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. J Biol Chem 289(52): 36204-36219.
9. Ryan, A. J., Larson-Casey, J. L., He, C., Murthy, S. and Carter, A. B. (2014). Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophages. J Biol Chem 289(48): 33391-33403.
10. Jaffer, O. A., Carter, A. B., Sanders, P. N., Dibbern, M. E., Winters, C. J., Murthy, S., Ryan, A. J., Rokita, A. G., Prasad, A. M., Zabner, J., Kline, J. N., Grumbach, I. M. and Anderson, M. E. (2015). Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-beta-mediated collagen production in a murine asthma model. Am J Respir Cell Mol Biol 52(1): 106-115.
11. Jang, J. H., Bruse, S., Huneidi, S., Schrader, R. M., Monick, M. M., Lin, Y., Carter, A. B., Klingelhutz, A. J. and Nyunoya, T. (2014). Acrolein-exposed normal human lung fibroblasts in vitro: cellular senescence, enhanced telomere erosion, and degradation of Werner's syndrome protein. Environ Health Perspect 122(9): 955-962.
12. He, C., Ryan, A. J., Murthy, S. and Carter, A. B. (2013). Accelerated development of pulmonary fibrosis via Cu,Zn-superoxide dismutase-induced alternative activation of macrophages. J Biol Chem 288(28): 20745-20757.
13. Pezzulo, A. A., Hornick, E. E., Rector, M. V., Estin, M., Reisetter, A. C., Taft, P. J., Butcher, S. C., Carter, A. B., Manak, J. R., Stoltz, D. A. and Zabner, J. (2012). Expression of human paraoxonase 1 decreases superoxide levels and alters bacterial colonization in the gut of Drosophila melanogaster. PLoS One 7(8): e43777.
14. Murthy, S., Ryan, A. J. and Carter, A. B. (2012). SP-1 regulation of MMP-9 expression requires Ser586 in the PEST domain. Biochem J 445(2): 229-236.
15. Scott, J. A., Xie, L., Li, H., Li, W., He, J. B., Sanders, P. N., Carter, A. B., Backs, J., Anderson, M. E. and Grumbach, I. M. (2012). The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9. Am J Physiol Heart Circ Physiol 302(10): H1953-1964.
16. Osborn-Heaford, H. L., Ryan, A. J., Murthy, S., Racila, A. M., He, C., Sieren, J. C., Spitz, D. R. and Carter, A. B. (2012). Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. J Biol Chem 287(5): 3301-3312.
17. He, C., Murthy, S., McCormick, M. L., Spitz, D. R., Ryan, A. J. and Carter, A. B. (2011). Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation. J Biol Chem 286(17): 15597-15607.
18. Williard, D. E., Twait, E., Yuan, Z., Carter, A. B. and Samuel, I. (2010). Nuclear factor kappa B-dependent gene transcription in cholecystokinin- and tumor necrosis factor-alpha-stimulated isolated acinar cells is regulated by p38 mitogen-activated protein kinase. Am J Surg 200(2): 283-290.
19. Murthy, S., Ryan, A., He, C., Mallampalli, R. K. and Carter, A. B. (2010). Rac1-mediated mitochondrial H2O2 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1. J Biol Chem 285(32): 25062-25073.
20. Murthy, S., Adamcakova-Dodd, A., Perry, S. S., Tephly, L. A., Keller, R. M., Metwali, N., Meyerholz, D. K., Wang, Y., Glogauer, M., Thorne, P. S. and Carter, A. B. (2009). Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 297(5): L846-855.
21. Ryan, A. J., Chen, B. B., Vennalaganti, P. R., Henderson, F. C., Tephly, L. A., Carter, A. B. and Mallampalli, R. K. (2008). 15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase. J Biol Chem 283(36): 24628-24640.
22. Cassel, S. L., Eisenbarth, S. C., Iyer, S. S., Sadler, J. J., Colegio, O. R., Tephly, L. A., Carter, A. B., Rothman, P. B., Flavell, R. A. and Sutterwala, F. S. (2008). The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A 105(26): 9035-9040.
23. Tephly, L. A. and Carter, A. B. (2008). Asbestos-induced MKP-3 expression augments TNF-alpha gene expression in human monocytes. Am J Respir Cell Mol Biol 39(1): 113-123.
24. Samuel, I., Tephly, L., Williard, D. E. and Carter, A. B. (2008). Enteral exclusion increases MAP kinase activation and cytokine production in a model of gallstone pancreatitis. Pancreatology 8(1): 6-14.
25. Tephly, L. A. and Carter, A. B. (2007). Constitutive NADPH oxidase and increased mitochondrial respiratory chain activity regulate chemokine gene expression. Am J Physiol Lung Cell Mol Physiol 293(5): L1143-1155.
26. Venkatachalam, P., de Toledo, S. M., Pandey, B. N., Tephly, L. A., Carter, A. B., Little, J. B., Spitz, D. R. and Azzam, E. I. (2008). Regulation of normal cell cycle progression by flavin-containing oxidases. Oncogene 27(1): 20-31.
27. Tephly, L. A. and Carter, A. B. (2007). Differential expression and oxidation of MKP-1 modulates TNF-alpha gene expression. Am J Respir Cell Mol Biol 37(3): 366-374.
28. Agassandian, M., Zhou, J., Tephly, L. A., Ryan, A. J., Carter, A. B. and Mallampalli, R. K. (2005). Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase. J Biol Chem 280(22): 21577-21587.