Ph.D, Joint degree between European Molecular Biology Laboratory, Hamburg, Germany and Faculty of Science and Technology, Institute for Molecular Biology, Aarhus University, Denmark, 2005
Group Leader/principle investigator. NCMM, Oslo University, Norway
-
Bjerregaard-Andersen, K., Ostensen, E., Scott, J. D., Tasken, K. and Morth, J. P. (2016). Malonate in the nucleotide-binding site traps human AKAP18gamma/delta in a novel conformational state. Acta Crystallogr F Struct Biol Commun 72(Pt 8): 591-597.
-
Gerner, L., Munack, S., Temmerman, K., Lawrence-Dorner, A. M., Besir, H., Wilmanns, M., Jensen, J. K., Thiede, B., Mills, I. G. and Morth, J. P. (2016). Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli. Data Brief 8: 733-740.
-
Gerner, L., Munack, S., Temmerman, K., Lawrence-Dorner, A. M., Besir, H., Wilmanns, M., Jensen, J. K., Thiede, B., Mills, I. G. and Morth, J. P. (2016). Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2. Biochem Biophys Res Commun 476(2): 102-107.
-
Hong, Z., De Meulemeester, L., Jacobi, A., Pedersen, J. S., Morth, J. P., Andreasen, P. A. and Jensen, J. K. (2016). Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN. J Biol Chem 291(27): 14340-14355.
-
Leo, J. C., Oberhettinger, P., Yoshimoto, S., Udatha, D. B., Morth, J. P., Schutz, M., Hori, K. and Linke, D. (2016). Secretion of the Intimin Passenger Domain Is Driven by Protein Folding. J Biol Chem 291(38): 20096-20112.
-
Subramani, S., Perdreau-Dahl, H. and Morth, J. P. (2016). The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro. Elife 5.
-
Ricanek, P., Lunde, L. K., Frye, S. A., Stoen, M., Nygard, S., Morth, J. P., Rydning, A., Vatn, M. H., Amiry-Moghaddam, M. and Tonjum, T. (2015). Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease. Clin Exp Gastroenterol 8: 49-67.
-
Sommer, T., Bjerregaard-Andersen, K., Simensen, S. M., Jensen, J. K., Jochimsen, B., Riss, P. J., Etzerodt, M. and Morth, J. P. (2015). Enzymatic detection and quantification assay of isatin, a putative stress biomarker in blood. ACS Chem Neurosci 6(8): 1353-1360.
-
Bjerregaard-Andersen, K., Sommer, T., Jensen, J. K., Jochimsen, B., Etzerodt, M. and Morth, J. P. (2014). A proton wire and water channel revealed in the crystal structure of isatin hydrolase. J Biol Chem 289(31): 21351-21359.
-
Ostenfeld, M. S., Jeppesen, D. K., Laurberg, J. R., Boysen, A. T., Bramsen, J. B., Primdal-Bengtson, B., Hendrix, A., Lamy, P., Dagnaes-Hansen, F., Rasmussen, M. H., Bui, K. H., Fristrup, N., Christensen, E. I., Nordentoft, I., Morth, J. P., Jensen, J. B., Pedersen, J. S., Beck, M., Theodorescu, D., Borre, M., Howard, K. A., Dyrskjot, L. and Orntoft, T. F. (2014). Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties. Cancer Res 74(20): 5758-5771.
-
Bjerregaard-Andersen, K., Perdreau-Dahl, H., Guldsten, H., Praetorius, J., Jensen, J. K. and Morth, J. P. (2013). The N-terminal cytoplasmic region of NCBE displays features of an intrinsic disordered structure and represents a novel target for specific drug screening. Front Physiol 4: 320.
-
Bublitz, M., Musgaard, M., Poulsen, H., Thogersen, L., Olesen, C., Schiott, B., Morth, J. P., Moller, J. V. and Nissen, P. (2013). Ion pathways in the sarcoplasmic reticulum Ca2+-ATPase. J Biol Chem 288(15): 10759-10765.
-
Groftehauge, M. K., Therkelsen, M. O., Taaning, R., Skrydstrup, T., Morth, J. P. and Nissen, P. (2013). Identifying ligand-binding hot spots in proteins using brominated fragments. Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 9): 1060-1065.
-
Kotsubei, A., Gorgel, M., Morth, J. P., Nissen, P. and Andersen, J. L. (2013). Probing determinants of cyclopiazonic acid sensitivity of bacterial Ca2+-ATPases. FEBS J 280(21): 5441-5449.
-
Nagelhus, E. A., Amiry-Moghaddam, M., Bergersen, L. H., Bjaalie, J. G., Eriksson, J., Gundersen, V., Leergaard, T. B., Morth, J. P., Storm-Mathisen, J., Torp, R., Walhovd, K. B. and Tonjum, T. (2013). The glia doctrine: addressing the role of glial cells in healthy brain ageing. Mech Ageing Dev 134(10): 449-459.
-
Voronkov, A., Holsworth, D. D., Waaler, J., Wilson, S. R., Ekblad, B., Perdreau-Dahl, H., Dinh, H., Drewes, G., Hopf, C., Morth, J. P. and Krauss, S. (2013). Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor. J Med Chem 56(7): 3012-3023.
-
Hein, K. L., Nissen, P. and Morth, J. P. (2012). Purification, crystallization and preliminary crystallographic studies of a PacL homologue from Listeria monocytogenes. Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 4): 424-427.
-
Preu, J., Panjikar, S., Morth, P., Jaiswal, R., Karunakar, P. and Tucker, P. A. (2012). The sensor region of the ubiquitous cytosolic sensor kinase, PdtaS, contains PAS and GAF domain sensing modules. J Struct Biol 177(2): 498-505.
-
Andersen, J. L., Gourdon, P., Moller, J. V., Morth, J. P. and Nissen, P. (2011). Crystallization and preliminary structural analysis of the Listeria monocytogenes Ca(2+)-ATPase LMCA1. Acta Crystallogr Sect F Struct Biol Cryst Commun 67(Pt 6): 718-722.
-
Arnou, B., Montigny, C., Morth, J. P., Nissen, P., Jaxel, C., Moller, J. V. and Maire, M. (2011). The Plasmodium falciparum Ca(2+)-ATPase PfATP6: insensitive to artemisinin, but a potential drug target. Biochem Soc Trans 39(3): 823-831.
-
Bublitz, M., Morth, J. P. and Nissen, P. (2011). P-type ATPases at a glance. J Cell Sci 124(Pt 15): 2515-2519.
-
Faxen, K., Andersen, J. L., Gourdon, P., Fedosova, N., Morth, J. P., Nissen, P. and Moller, J. V. (2011). Characterization of a Listeria monocytogenes Ca(2+) pump: a SERCA-type ATPase with only one Ca(2+)-binding site. J Biol Chem 286(2): 1609-1617.
-
Gourdon, P., Liu, X. Y., Skjorringe, T., Morth, J. P., Moller, L. B., Pedersen, B. P. and Nissen, P. (2011). Crystal structure of a copper-transporting PIB-type ATPase. Nature 475(7354): 59-64.
-
Jensen, J. K., Thompson, L. C., Bucci, J. C., Nissen, P., Gettins, P. G., Peterson, C. B., Andreasen, P. A. and Morth, J. P. (2011). Crystal structure of plasminogen activator inhibitor-1 in an active conformation with normal thermodynamic stability. J Biol Chem 286(34): 29709-29717.
-
Morth, J. P., Pedersen, B. P., Buch-Pedersen, M. J., Andersen, J. P., Vilsen, B., Palmgren, M. G. and Nissen, P. (2011). A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps. Nat Rev Mol Cell Biol 12(1): 60-70.
-
Bublitz, M., Poulsen, H., Morth, J. P. and Nissen, P. (2010). In and out of the cation pumps: P-type ATPase structure revisited. Curr Opin Struct Biol 20(4): 431-439.
-
Hein, K. L., Kragh-Hansen, U., Morth, J. P., Jeppesen, M. D., Otzen, D., Moller, J. V. and Nissen, P. (2010). Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin. J Struct Biol 171(3): 353-360.
-
Pedersen, B. P., Morth, J. P. and Nissen, P. (2010). Structure determination using poorly diffracting membrane-protein crystals: the H+-ATPase and Na+,K+-ATPase case history. Acta Crystallogr D Biol Crystallogr 66(Pt 3): 309-313.
-
Poulsen, H., Khandelia, H., Morth, J. P., Bublitz, M., Mouritsen, O. G., Egebjerg, J. and Nissen, P. (2010). Neurological disease mutations compromise a C-terminal ion pathway in the na(+)/K(+)-ATPase. Nature 467 (2010) 99-102.
-
Poulsen, H., Morth, P., Egebjerg, J. and Nissen, P. (2010). Phosphorylation of the Na+,K+-ATPase and the H+,K+-ATPase. FEBS Lett 584(12): 2589-2595.