Minnie Malik
  • Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, USA
Research fields
  • Cell biology
Personal information


Ph.D. University of Delhi, India, 1991

Current position

Research Assistant Professor, Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences

Publications (since 2006)

  1. Patel, A., Malik, M., Britten, J., Cox, J. and Catherino, W. H. (2016). Mifepristone inhibits extracellular matrix formation in uterine leiomyoma. Fertil Steril 105(4): 1102-1110.

  2. Malik, M., Britten, J., Cox, J., Patel, A. and Catherino, W. H. (2016). Gonadotropin-releasing hormone analogues inhibit leiomyoma extracellular matrix despite presence of gonadal hormones. Fertil Steril 105(1): 214-224.

  3. Patel, A., Malik, M., Britten, J., Cox, J. and Catherino, W. H. (2014). Alternative therapies in management of leiomyomas. Fertil Steril 102(3): 649-655.

  4. Malik, M., Britten, J., Segars, J. and Catherino, W. H. (2014). Leiomyoma cells in 3-dimensional cultures demonstrate an attenuated response to fasudil, a rho-kinase inhibitor, when compared to 2-dimensional cultures. Reprod Sci 21(9): 1126-1138.

  5. Levy, G., Malik, M., Britten, J., Gilden, M., Segars, J. and Catherino, W. H. (2014). Liarozole inhibits transforming growth factor-beta3--mediated extracellular matrix formation in human three-dimensional leiomyoma cultures. Fertil Steril 102(1): 272-281 e272.

  6. Malik, M., Segars, J. and Catherino, W. H. (2012). Integrin beta1 regulates leiomyoma cytoskeletal integrity and growth. Matrix Biol 31(7-8): 389-397.

  7. Britten, J. L., Malik, M., Levy, G., Mendoza, M. and Catherino, W. H. (2012). Gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production. Fertil Steril 98(5): 1299-1307.

  8. Gilden, M., Malik, M., Britten, J., Delgado, T., Levy, G. and Catherino, W. H. (2012). Leiomyoma fibrosis inhibited by liarozole, a retinoic acid metabolic blocking agent. Fertil Steril 98(6): 1557-1562.

  9. Malik, M. and Catherino, W. H. (2012). Development and validation of a three-dimensional in vitro model for uterine leiomyoma and patient-matched myometrium. Fertil Steril 97(6): 1287-1293.

  10. Norian, J. M., Owen, C. M., Taboas, J., Korecki, C., Tuan, R., Malik, M., Catherino, W. H. and Segars, J. H. (2012). Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma. Matrix Biol 31(1): 57-65.

  11. McCarthy-Keith, D. M., Malik, M., Britten, J., Segars, J. and Catherino, W. H. (2011). Gonadotropin-releasing hormone agonist increases expression of osmotic response genes in leiomyoma cells. Fertil Steril 95(7): 2383-2387.

  12. Catherino, W. H., Malik, M., Driggers, P., Chappel, S., Segars, J. and Davis, J. (2010). Novel, orally active selective progesterone receptor modulator CP8947 inhibits leiomyoma cell proliferation without adversely affecting endometrium or myometrium. J Steroid Biochem Mol Biol 122(4): 279-286.

  13. Mayers, C. M., Wadell, J., McLean, K., Venere, M., Malik, M., Shibata, T., Driggers, P. H., Kino, T., Guo, X. C., Koide, H., Gorivodsky, M., Grinberg, A., Mukhopadhyay, M., Abu-Asab, M., Westphal, H. and Segars, J. H. (2010). The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice. J Biol Chem 285(16): 12344-12354.

  14. Malik, M., Norian, J., McCarthy-Keith, D., Britten, J. and Catherino, W. H. (2010). Why leiomyomas are called fibroids: the central role of extracellular matrix in symptomatic women. Semin Reprod Med 28(3): 169-179.

  15. Norian, J. M., Malik, M., Parker, C. Y., Joseph, D., Leppert, P. C., Segars, J. H. and Catherino, W. H. (2009). Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas. Reprod Sci 16(12): 1153-1164.

  16. Joseph, D. S., Malik, M., Nurudeen, S. and Catherino, W. H. (2010). Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor beta-3. Fertil Steril 93(5): 1500-1508.

  17. Payson, M., Malik, M., Siti-Nur Morris, S., Segars, J. H., Chason, R. and Catherino, W. H. (2009). Activating transcription factor 3 gene expression suggests that tissue stress plays a role in leiomyoma development. Fertil Steril 92(2): 748-755.

  18. Malik, M., Mendoza, M., Payson, M. and Catherino, W. H. (2009). Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression. Fertil Steril 91(5 Suppl): 2177-2184.

  19. Rogers, R., Norian, J., Malik, M., Christman, G., Abu-Asab, M., Chen, F., Korecki, C., Iatridis, J., Catherino, W. H., Tuan, R. S., Dhillon, N., Leppert, P. and Segars, J. H. (2008). Mechanical homeostasis is altered in uterine leiomyoma. Am J Obstet Gynecol 198(4): 474 e471-411.

  20. Malik, M., Webb, J. and Catherino, W. H. (2008). Retinoic acid treatment of human leiomyoma cells transformed the cell phenotype to one strongly resembling myometrial cells. Clin Endocrinol (Oxf) 69(3): 462-470.

  21. Parker, J. D., Malik, M. and Catherino, W. H. (2007). Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor. Fertil Steril 88(1): 39-46.

  22. Catherino, W. H. and Malik, M. (2007). Uterine leiomyomas express a molecular pattern that lowers retinoic acid exposure. Fertil Steril 87(6): 1388-1398.

  23. Malik, M. and Catherino, W. H. (2007). Novel method to characterize primary cultures of leiomyoma and myometrium with the use of confirmatory biomarker gene arrays. Fertil Steril 87(5): 1166-1172.

  24. Daly, K. T., Tracy, A. C., Malik, M., Wang, T., Francke-Carroll, S. and Magnuson, B. A. (2007). Enhanced estrogenic responses and sensitivity to azoxymethane following dietary soy isoflavone supplementation in older female rats. Food Chem Toxicol 45(4): 628-637.

  25. Lala, G., Malik, M., Zhao, C., He, J., Kwon, Y., Giusti, M. M. and Magnuson, B. A. (2006). Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats. Nutr Cancer 54(1): 84-93.

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