Piero Crespo
  • Faculty, Consejo Superior de Investigaciones Científicas
Research fields
  • Biochemistry, Cancer Biology
Personal information


Ph.D in Biological Sciences , Department of Molecular Biology, University of Cantabria (SPAIN), 1991

Current position

Professor and Director of Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC) , Consejo Superior de Investigaciones Científicas (CSIC)

Publications (since 2005)

  1. Herrero, A. and Crespo, P. (2016). Tumors topple when ERKs uncouple. Mol Cell Oncol 3(2): e1091875.

  2. Casar, B. and Crespo, P. (2016). ERK Signals: Scaffolding Scaffolds? Front Cell Dev Biol 4: 49.

  3. Herrero, A., Casar, B., Colon-Bolea, P., Agudo-Ibanez, L. and Crespo, P. (2016). Defined spatiotemporal features of RAS-ERK signals dictate cell fate in MCF-7 mammary epithelial cells. Mol Biol Cell 27(12): 1958-1968.

  4. Munoz-Felix, J. M., Fuentes-Calvo, I., Cuesta, C., Eleno, N., Crespo, P., Lopez-Novoa, J. M. and Martinez-Salgado, C. (2016). Absence of K-Ras Reduces Proliferation and Migration But Increases Extracellular Matrix Synthesis in Fibroblasts. J Cell Physiol 231(10): 2224-2235.

  5. Herrero, A., Pinto, A., Colon-Bolea, P., Casar, B., Jones, M., Agudo-Ibanez, L., Vidal, R., Tenbaum, S. P., Nuciforo, P., Valdizan, E. M., Horvath, Z., Orfi, L., Pineda-Lucena, A., Bony, E., Keri, G., Rivas, G., Pazos, A., Gozalbes, R., Palmer, H. G., Hurlstone, A. and Crespo, P. (2015). Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell 28(2): 170-182.

  6. Agudo-Ibanez, L., Herrero, A., Barbacid, M. and Crespo, P. (2015). H-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events. Mol Cell Biol 35(11): 1898-1914.

  7. Colon-Bolea, P. and Crespo, P. (2014). Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway. Bioessays 36(12): 1162-1169.

  8. Baschieri, F., Confalonieri, S., Bertalot, G., Di Fiore, P. P., Dietmaier, W., Leist, M., Crespo, P., Macara, I. G. and Farhan, H. (2014). Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Nat Commun 5: 4839.

  9. Fuentes-Calvo, I., Crespo, P., Santos, E., Lopez-Novoa, J. M. and Martinez-Salgado, C. (2013). The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts. Biochim Biophys Acta 1833(12): 2734-2744.

  10. Casar, B., Rodriguez, J., Gibor, G., Seger, R. and Crespo, P. (2012). Mxi2 sustains ERK1/2 phosphorylation in the nucleus by preventing ERK1/2 binding to phosphatases. Biochem J 441(2): 571-578.

  11. Matallanas, D., Romano, D., Al-Mulla, F., O'Neill, E., Al-Ali, W., Crespo, P., Doyle, B., Nixon, C., Sansom, O., Drosten, M., Barbacid, M. and Kolch, W. (2011). Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol Cell 44(6): 893-906.

  12. Crespo, P., Calvo, F. and Sanz-Moreno, V. (2011). Ras and Rho GTPases on the move: The RasGRF connection. Bioarchitecture 1(4): 200-204.

  13. Rodriguez, J. and Crespo, P. (2011). Working without kinase activity: phosphotransfer-independent functions of extracellular signal-regulated kinases. Sci Signal 4(196): re3.

  14. Arozarena, I., Calvo, F. and Crespo, P. (2011). Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events. Genes Cancer 2(3): 182-194.

  15. Calvo, F., Sanz-Moreno, V., Agudo-Ibanez, L., Wallberg, F., Sahai, E., Marshall, C. J. and Crespo, P. (2011). RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation. Nat Cell Biol 13(7): 819-826.

  16. Matallanas, D. and Crespo, P. (2010). New druggable targets in the Ras pathway? Curr Opin Mol Ther 12(6): 674-683.

  17. Rodriguez, J., Calvo, F., Gonzalez, J. M., Casar, B., Andres, V. and Crespo, P. (2010). ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes. J Cell Biol 191(5): 967-979.

  18. Pinto, A. and Crespo, P. (2010). Analysis of ERKs' dimerization by electrophoresis. Methods Mol Biol 661: 335-342.

  19. Chiariello, M., Vaque, J. P., Crespo, P. and Gutkind, J. S. (2010). Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors. Methods Mol Biol 661: 137-150.

  20. Calvo, F., Agudo-Ibanez, L. and Crespo, P. (2010). The Ras-ERK pathway: understanding site-specific signaling provides hope of new anti-tumor therapies. Bioessays 32(5): 412-421.

  21. Calvo, F. and Crespo, P. (2009). Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors. Mol Biol Cell 20(20): 4289-4302.

  22. Casar, B., Pinto, A. and Crespo, P. (2009). ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task. Cell Cycle 8(7): 1007-1013.

  23. Casar, B., Arozarena, I., Sanz-Moreno, V., Pinto, A., Agudo-Ibanez, L., Marais, R., Lewis, R. E., Berciano, M. T. and Crespo, P. (2009). Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins. Mol Cell Biol 29(5): 1338-1353.

  24. Gonzalez, J. M., Navarro-Puche, A., Casar, B., Crespo, P. and Andres, V. (2008). Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. J Cell Biol 183(4): 653-666.

  25. Casar, B., Pinto, A. and Crespo, P. (2008). Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes. Mol Cell 31(5): 708-721.

  26. Vaque, J. P., Fernandez-Garcia, B., Garcia-Sanz, P., Ferrandiz, N., Bretones, G., Calvo, F., Crespo, P., Marin, M. C. and Leon, J. (2008). c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation. Mol Cancer Res 6(2): 325-339.

  27. Agudo-Ibanez, L., Nunez, F., Calvo, F., Berenjeno, I. M., Bustelo, X. R. and Crespo, P. (2007). Transcriptomal profiling of site-specific Ras signals. Cell Signal 19(11): 2264-2276.

  28. Martinez, S. E., Lazaro-Dieguez, F., Selva, J., Calvo, F., Piqueras, J. R., Crespo, P., Claro, E. and Egea, G. (2007). Lysophosphatidic acid rescues RhoA activation and phosphoinositides levels in astrocytes exposed to ethanol. J Neurochem 102(4): 1044-1052.

  29. Casar, B., Sanz-Moreno, V., Yazicioglu, M. N., Rodriguez, J., Berciano, M. T., Lafarga, M., Cobb, M. H. and Crespo, P. (2007). Mxi2 promotes stimulus-independent ERK nuclear translocation. EMBO J 26(3): 635-646.

  30. Peregrin, S., Jurado-Pueyo, M., Campos, P. M., Sanz-Moreno, V., Ruiz-Gomez, A., Crespo, P., Mayor, F., Jr. and Murga, C. (2006). Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK. Curr Biol 16(20): 2042-2047.

  31. Bernal, J. and Crespo, P. (2006). Analysis of Rhes activation state and effector function. Methods Enzymol 407: 535-542.

  32. Matallanas, D., Sanz-Moreno, V., Arozarena, I., Calvo, F., Agudo-Ibanez, L., Santos, E., Berciano, M. T. and Crespo, P. (2006). Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation. Mol Cell Biol 26(1): 100-116.

  33. Vaque, J. P., Navascues, J., Shiio, Y., Laiho, M., Ajenjo, N., Mauleon, I., Matallanas, D., Crespo, P. and Leon, J. (2005). Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway. J Biol Chem 280(2): 1112-1122.

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