Fabio Candotti
  • Disorders of Immunity Section, Genetics and Molecular Biology Branch, NHGRI, NIH, USA
Research focus
  • Cell biology
  • 1 Author merit


MD in Medicine, School of Medicine, University of Brescia, Italy, 1987

Current position

Associate Professor of Medicine, University of Lausanne
Attending Physician, Division of Immunology and Allergy, University Hospital of Lausanne
Attending Physician, Division of Immunology and Allergy, University Hospital of Lausanne


  1. Volpi, S., Santori, E., Abernethy, K., Mizui, M., Dahlberg, C. I., Recher, M., Capuder, K., Csizmadia, E., Ryan, D., Mathew, D., Tsokos, G. C., Snapper, S., Westerberg, L. S., Thrasher, A. J., Candotti, F. and Notarangelo, L. D. (2016). N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome. Blood 127(2): 216-220.

  2. Yokoyama, T., Yoshizaki, A., Simon, K. L., Kirby, M. R., Anderson, S. M. and Candotti, F. (2015). Age-Dependent Defects of Regulatory B Cells in Wiskott-Aldrich Syndrome Gene Knockout Mice. PLoS One 10(10): e0139729.

  3. Crestani, E., Volpi, S., Candotti, F., Giliani, S., Notarangelo, L. D., Chu, J., Aldave Becerra, J. C., Buchbinder, D., Chou, J., Geha, R. S., Kanariou, M., King, A., Mazza, C., Moratto, D., Sokolic, R., Garabedian, E., Porta, F., Putti, M. C., Wakim, R. H., Tsitsikov, E., Pai, S. Y. and Notarangelo, L. D. (2015). Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J Allergy Clin Immunol 136(5): 1401-1404 e1401-1403.

  4. Simon, K. L., Anderson, S. M., Garabedian, E. K., Moratto, D., Sokolic, R. A. and Candotti, F. (2014). Molecular and phenotypic abnormalities of B lymphocytes in patients with Wiskott-Aldrich syndrome. J Allergy Clin Immunol 133(3): 896-899 e894.

  5. Adriani, M., Jones, K. A., Uchiyama, T., Kirby, M. R., Silvin, C., Anderson, S. M. and Candotti, F. (2011). Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells. Blood 117(24): 6608-6611.

  6. Nikolov, N. P., Shimizu, M., Cleland, S., Bailey, D., Aoki, J., Strom, T., Schwartzberg, P. L., Candotti, F. and Siegel, R. M. (2010). Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein. Blood 116(5): 740-747.

  7. Adriani, M., Aoki, J., Horai, R., Thornton, A. M., Konno, A., Kirby, M., Anderson, S. M., Siegel, R. M., Candotti, F. and Schwartzberg, P. L. (2007). Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol 124(1): 41-48.

  8. Wada, T., Schurman, S. H., Garabedian, E. K., Yachie, A. and Candotti, F. (2005). Analysis of T-cell repertoire diversity in Wiskott-Aldrich syndrome. Blood 106(12): 3895-3897.

  9. Wada, T., Schurman, S. H., Jagadeesh, G. J., Garabedian, E. K., Nelson, D. L. and Candotti, F. (2004). Multiple patients with revertant mosaicism in a single Wiskott-Aldrich syndrome family. Blood 104(5): 1270-1272.

  10. Konno, A., Wada, T., Schurman, S. H., Garabedian, E. K., Kirby, M., Anderson, S. M. and Candotti, F. (2004). Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T- and B-cell lineages. Blood 103(2): 676-678.

  11. Wada, T., Konno, A., Schurman, S. H., Garabedian, E. K., Anderson, S. M., Kirby, M., Nelson, D. L. and Candotti, F. (2003). Second-site mutation in the Wiskott-Aldrich syndrome (WAS) protein gene causes somatic mosaicism in two WAS siblings. J Clin Invest 111(9): 1389-1397.

  12. Wada, T., Schurman, S. H., Otsu, M., Garabedian, E. K., Ochs, H. D., Nelson, D. L. and Candotti, F. (2001). Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism. Proc Natl Acad Sci U S A 98(15): 8697-8702.

1 Protocol published
Detection of Reactive Oxygen Species Using MitoSOX and CellROX in Zebrafish
Authors:  Alberto Rissone and Fabio Candotti, date: 10/05/2016, view: 23248, Q&A: 1
The production of free radicals is the result of normal cellular metabolism. Free radicals are involved in innumerable different cellular and biological functions such as signaling, proliferation, cell death, aging, inflammation, etc. Under ...
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