Jian'an Wang
  • Second Affiliated hospital Zhejiang University college of Medicine of clinic research center, China
Research fields
  • Developmental biology
Personal information


Ph.D in Medicine, Department of Medicine, Zhejiang University, 2000

Current position

Chairman of The Second Affiliated hospital of Zhejiang University School


  1. Hu, X., Xu, Y., Zhong, Z., Wu, Y., Zhao, J., Wang, Y., Cheng, H., Kong, M., Zhang, F., Chen, Q., Sun, J., Li, Q., Jin, J., Li, Q., Chen, L., Wang, C., Zhan, H., Fan, Y., Yang, Q., Yu, L., Wu, R., Liang, J., Zhu, J., Wang, Y., Jin, Y., Lin, Y., Yang, F., Jia, L., Zhu, W., Chen, J., Yu, H., Zhang, J. and Wang, J. (2016). A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman Primates: Paracrine Activity Without Remuscularization. Circ Res 118(6): 970-983.
  2. Cai, Z., Shen, L., Ma, H., Yang, J., Yang, D., Chen, H., Wei, J., Lu, Q., Wang, D. W., Xiang, M. and Wang, J. (2015). Involvement of Endoplasmic Reticulum Stress-Mediated C/EBP Homologous Protein Activation in Coxsackievirus B3-Induced Acute Viral Myocarditis. Circ Heart Fail 8(4): 809-818.
  3. Wang, Y., Pan, X., Fan, Y., Hu, X., Liu, X., Xiang, M. and Wang, J. (2015). Dysregulated expression of microRNAs and mRNAs in myocardial infarction. Am J Transl Res 7(11): 2291-2304.
  4. Hu, P., Tang, M. Y., Song, W. C., Jiang, J., Sun, Y., Liu, X. B., Li, C. L., Hu, X. Y. and Wang, J. A. (2015). Fractional Flow Reserve Guided Percutaneous Coronary Intervention Improves Clinical Outcome with Reduced Cost in Contemporary Clinical Practice. Chin Med J (Engl) 128(15): 2000-2005.
  5. Chen, J., Lou, H., Jiang, B., Shao, R., Ruan, Z. and Wang, J. (2015). Simultaneous determination of hyzetimibe and its main active metabolite in plasma by LC-MS/MS and its application in PK study. Bioanalysis 7(15): 1857-1867.
  6. Zhao, X. G., Jiang, S. Y., Zhang, M., Zhou, G. J., Zhao, Y. Y., Yi, H. X., Jiang, L. B. and Wang, J. A. (2015). Ideal target arterial pressure after control of bleeding in a rabbit model of severe traumatic hemorrhagic shock: results from volume loading-based fluid resuscitation. J Surg Res 196(2): 358-367.
  7. Hu, X., Zhang, L., Jin, J., Zhu, W., Xu, Y., Wu, Y., Wang, Y., Chen, H., Webster, K. A., Chen, H., Yu, H. and Wang, J. (2015). Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem Cells 33(6): 1850-1862.
  8. Liu, X. B., Jiang, J. B., Zhou, Q. J., Pu, Z. X., He, W., Dong, A. Q., Feng, Y., Jiang, J., Sun, Y., Xiang, M. X., He, Y. X., Fan, Y. Q., Dong, L. and Wang, J. A. (2015). Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population. J Zhejiang Univ Sci B 16(3): 208-214.
  9. Hu, X., Huang, X., Yang, Q., Wang, L., Sun, J., Zhan, H., Lin, J., Pu, Z., Jiang, J., Sun, Y., Xiang, M., Liu, X., Xie, X., Yu, X., Chen, Z., Tse, H. F., Zhang, J. and Wang, J. (2015). Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial. Int J Cardiol 184: 446-451.
  10. Zhou, Q., Liu, X., Dong, A., Pu, Z., He, W., Feng, Y. and Wang, J. (2014). [Value of preoperative assessment on transcatheter aortic valve implantation procedure with high-pitch dual-source computed tomography angiography]. Zhonghua Xin Xue Guan Bing Za Zhi 42(10): 835-839.
  11. Sun, Y., Jiang, J., Zhu, G., Li, C., Dong, L., Liu, X., Lyu, L., Hu, X., Xiang, M. and Wang, J. (2014). [Efficacy of intravascular ultrasound guided rotational atherectomy for heavily calcified coronary lesions]. Zhonghua Xin Xue Guan Bing Za Zhi 42(7): 545-550.
  12. Ruan, Z., Jiang, B., Chen, J., Zhang, X., Lou, H., Xiang, M., Shao, Q. and Wang, J. (2014). Pharmacokinetics, pharmacodynamics, safety, and tolerability of hyzetimibe (HS-25) in healthy Chinese subjects. J Clin Pharmacol 54(10): 1144-1152.
  13. Xie, X. J., Jiang, J. B., Jiang, J. and Wang, J. A. (2014). Concurrent pulmonary thrombosis with systemic embolism: a case report. J Zhejiang Univ Sci B 15(9): 838-844.
  14. Liu, X., Chen, H., Zhu, W., Chen, H., Hu, X., Jiang, Z., Xu, Y., Zhou, Y., Wang, K., Wang, L., Chen, P., Hu, H., Wang, C., Zhang, N., Ma, Q., Huang, M., Hu, D., Zhang, L., Wu, R., Wang, Y., Xu, Q., Yu, H. and Wang, J. (2014). Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model. J Heart Lung Transplant 33(10): 1083-1092.
  15. Chen, H., Liu, X., Zhu, W., Chen, H., Hu, X., Jiang, Z., Xu, Y., Wang, L., Zhou, Y., Chen, P., Zhang, N., Hu, D., Zhang, L., Wang, Y., Xu, Q., Wu, R., Yu, H. and Wang, J. (2014). SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin. Front Aging Neurosci 6: 103.
  16. Hu, X., Wu, R., Jiang, Z., Wang, L., Chen, P., Zhang, L., Yang, L., Wu, Y., Chen, H., Chen, H., Xu, Y., Zhou, Y., Huang, X., Webster, K. A., Yu, H. and Wang, J. (2014). Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells 32(10): 2702-2713.
  17. Hu, X., Wu, R., Shehadeh, L. A., Zhou, Q., Jiang, C., Huang, X., Zhang, L., Gao, F., Liu, X., Yu, H., Webster, K. A. and Wang, J. (2014). Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells. BMC Genomics 15: 303.
  18. Chen, H., Liu, X., Chen, H., Cao, J., Zhang, L., Hu, X. and Wang, J. (2014). Role of SIRT1 and AMPK in mesenchymal stem cells differentiation. Ageing Res Rev 13: 55-64.
  19. Zhang, Z., Wang, J. A., Xu, Y., Jiang, Z., Wu, R., Wang, L., Chen, P., Hu, X. and Yu, H. (2013). Menstrual blood derived mesenchymal cells ameliorate cardiac fibrosis via inhibition of endothelial to mesenchymal transition in myocardial infarction. Int J Cardiol 168(2): 1711-1714.
  20. Xu, Y., Hu, X., Wang, L., Jiang, Z., Liu, X., Yu, H., Zhang, Z., Chen, H., Chen, H., Steinhoff, G., Li, J. and Wang, J. (2013). Transplantation of preconditioned bone marrow mononuclear cells by AT2R stimulation improves infarcted heart function via enhanced cardiac mobilization of implanted cells. Int J Cardiol 168(4): 4551-4554.
  21. Chen, H., Wang, J., Xiang, M. X., Lin, Y., He, A., Jin, C. N., Guan, J., Sukhova, G. K., Libby, P., Wang, J. A. and Shi, G. P. (2013). Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction. Cardiovasc Res 100(1): 84-94.
  22. Jiang, Z., Hu, X., Yu, H., Xu, Y., Wang, L., Chen, H., Chen, H., Wu, R., Zhang, Z., Xiang, C., Webster, K. A. and Wang, J. A. (2013). Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms. J Cell Mol Med 17(10): 1247-1260.
  23. Ma, L. L., Zhang, F. J., Qian, L. B., Kong, F. J., Sun, J. F., Zhou, C., Peng, Y. N., Xu, H. J., Wang, W. N., Wen, C. Y., Zhu, M. H., Chen, G., Yu, L. N., Liu, X. B., Wang, J. A. and Yan, M. (2013). Hypercholesterolemia blocked sevoflurane-induced cardioprotection against ischemia-reperfusion injury by alteration of the MG53/RISK/GSK3beta signaling. Int J Cardiol 168(4): 3671-3678.
  24. Liu, X. B. and Wang, J. A. (2013). Update of transcatheter valve treatment. J Zhejiang Univ Sci B 14(8): 670-675.
  25. Jiang, J., Sun, Y., Xiang, M. X., Dong, L., Liu, X. B., Hu, X. Y., Feng, Y. and Wang, J. A. (2012). Complex coronary lesions and rotational atherectomy: one hospital's experience. J Zhejiang Univ Sci B 13(8): 645-651.
  26. Wang, J. A. (2012). Progress and challenges in the cardiovascular field. J Zhejiang Univ Sci B 13(8): 587-588.
  27. Liu, X. B., Chen, H., Chen, H. Q., Zhu, M. F., Hu, X. Y., Wang, Y. P., Jiang, Z., Xu, Y. C., Xiang, M. X. and Wang, J. A. (2012). Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation. J Zhejiang Univ Sci B 13(8): 616-623.
  28. Yi, J. H., Liu, H. B., Zhang, M., Wu, J. S., Yang, J. X., Chen, J. M., Xu, S. X. and Wang, J. A. (2012). Management of traumatic hemothorax by closed thoracic drainage using a central venous catheter. J Zhejiang Univ Sci B 13(1): 43-48.
  29. Zhou, J., Wang, J. A., Jiang, B., Qiu, W. J., Yan, B. and Wang, Y. H. (2013). A clinical, neurolinguistic, and radiological study of a Chinese follow-up case with primary progressive aphasia. Neurocase 19(5): 427-433.
  30. Zhang, Z. and Wang, J. (2012). Menstrual blood stem cells attenuate post-infarction fibrosis via inhibiting endothelial to mesenchymal transition (ENDMT). Heart 98:E36.
  31. Xie, X., Wang, Y., Zhang, S., Zhang, G., Xu, Y., Bi, H., Daugherty, A. and Wang, J. A. (2012). Chinese red yeast rice attenuates the development of angiotensin II-induced abdominal aortic aneurysm and atherosclerosis. J Nutr Biochem 23(6): 549-556.
  32. Pan, X. H., Zhang, S. Z., Chen, H. Q., Xiang, M. X. and Wang, J. A. (2011). Spuriously high B-type natriuretic peptide level caused by human antimouse antibodies. Ann Intern Med 155(6): 407-408.
  33. Xu, Q., Wang, J., He, J., Zhou, M., Adi, J., Webster, K. A. and Yu, H. (2011). Impaired CXCR4 expression and cell engraftment of bone marrow-derived cells from aged atherogenic mice. Atherosclerosis 219(1): 92-99.
  34. Shao, H., Xu, Q., Wu, Q., Ma, Q., Salgueiro, L., Wang, J., Eton, D., Webster, K. A. and Yu, H. (2011). Defective CXCR4 expression in aged bone marrow cells impairs vascular regeneration. J Cell Mol Med 15(10): 2046-2056.
  35. Xiang, M., Sun, J., Lin, Y., Zhang, J., Chen, H., Yang, D., Wang, J. and Shi, G. P. (2011). Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population. Atherosclerosis 215(2): 494-499.
  36. Wang, Y., Hu, X., Xie, X., He, A., Liu, X. and Wang, J. A. (2011). Effects of mesenchymal stem cells on matrix metalloproteinase synthesis in cardiac fibroblasts. Exp Biol Med (Maywood) 236(10): 1197-1204.
  37. Jin, C. N., Ma, H., Lin, Y., Wang, J. A. and Xiang, M. X. (2011). Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease. J Zhejiang Univ Sci B 12(8): 660-667.
  38. Guodong, J., Beili, F., Peng, C., Oushan, T., Jian, W., Ji, M., Yuping, S. and Geng, X. (2011). Coagulation factor XIII-A Val34Leu polymorphism and the risk of coronary artery disease and myocardial infarction in a Chinese Han population. Clin Appl Thromb Hemost 17(2): 208-213.
  39. Wang, W. X., Hu, X. Y., Xie, X. J., Liu, X. B., Wu, R. R., Wang, Y. P., Gao, F. and Wang, J. A. (2011). Nerve growth factor induces cord formation of mesenchymal stem cell by promoting proliferation and activating the PI3K/Akt signaling pathway. Acta Pharmacol Sin 32(12): 1483-1490.
  40. Wang, J. A., Chen, W. A., Wang, Y., Zhang, S., Bi, H., Hong, B., Luo, Y., Daugherty, A. and Xie, X. (2011). Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms. Atherosclerosis 217(1): 90-96.
  41. Hu, X., Wei, L., Taylor, T. M., Wei, J., Zhou, X., Wang, J. A. and Yu, S. P. (2011). Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation. Am J Physiol Cell Physiol 301(2): C362-372.
  42. Wang, Y., Hu, X., Wang, J. A., Xiang, M., Yu, J., Liu, F. and Feng, Y. (2011). Application of serum protein fingerprint in diagnosis of coronary artery disease. Clin Biochem 44(2-3): 185-191.
  43. Hu, X. Y., Wang, W. X., Yu, M. J., Liu, X. B., Wu, R. R., Gao, F., Huang, X., Cao, J., Xie, X. J. and Wang, J. A. (2011). Tongxinluo promotes mesenchymal stem cell tube formation in vitro. J Zhejiang Univ Sci B 12(8): 644-651.
  44. Wang, J., Cheng, X., Xiang, M. X., Alanne-Kinnunen, M., Wang, J. A., Chen, H., He, A., Sun, X., Lin, Y., Tang, T. T., Tu, X., Sjoberg, S., Sukhova, G. K., Liao, Y. H., Conrad, D. H., Yu, L., Kawakami, T., Kovanen, P. T., Libby, P. and Shi, G. P. (2011). IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest 121(9): 3564-3577.
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