Subba Rao Gangi Setty
  • Department of Microbiology and Cell Biology, Indian Institute of Science, India
Research focus
  • Biochemistry
Personal information


Ph.D. in Biotechnology, Jawaharlal Nehru University, New Delhi (IMTECH), India, 2001

Current position

Assistant Professor, Department of Microbiology and Cell Biology, Institute of Science, Bangalore, India


  1. Jani, R. A., Mahanty, S. and Setty, S. R. (2016). SNAREs in the maturation and function of LROs. Bioarchitecture 6(1): 1-11.
  2. Mahanty, S., Ravichandran, K., Chitirala, P., Prabha, J., Jani, R. A. and Setty, S. R. (2016). Rab9A is required for delivery of cargo from recycling endosomes to melanosomes. Pigment Cell Melanoma Res 29(1): 43-59.
  3. Jani, R. A., Purushothaman, L. K., Rani, S., Bergam, P. and Setty, S. R. (2015). STX13 regulates cargo delivery from recycling endosomes during melanosome biogenesis. J Cell Sci 128(17): 3263-3276.
  4. Dennis, M. K., Mantegazza, A. R., Snir, O. L., Tenza, D., Acosta-Ruiz, A., Delevoye, C., Zorger, R., Sitaram, A., de Jesus-Rojas, W., Ravichandran, K., Rux, J., Sviderskaya, E. V., Bennett, D. C., Raposo, G., Marks, M. S.* and Setty, S. R.* (2015). BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery. J Cell Biol 209(4): 563-577. (*Equal contribution as a senior author).
  5. Jani, R. A. and Setty S. R. (2014). Membrane traffic and vesicle fusion: Post-Palade era researchers win the Nobel Prize. Resonance May: 1-25.
  6. Sitaram, A., Dennis, M. K., Chaudhuri, R., De Jesus-Rojas, W., Tenza, D., Setty, S. R., Wood, C. S., Sviderskaya, E. V., Bennett, D. C., Raposo, G., Bonifacino, J. S. and Marks, M. S. (2012). Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes. Mol Biol Cell 23(16): 3178-3192.
  7. Truschel, S. T., Simoes, S., Setty, S. R., Harper, D. C., Tenza, D., Thomas, P. C., Herman, K. E., Sackett, S. D., Cowan, D. C., Theos, A. C., Raposo, G. and Marks, M. S. (2009). ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane. Traffic 10(9): 1318-1336.
  8. Setty, S. R., Tenza, D., Sviderskaya, E. V., Bennett, D. C., Raposo, G. and Marks, M. S. (2008). Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes. Nature 454(7208): 1142-1146.
  9. Setty, S. R., Tenza, D., Truschel, S. T., Chou, E., Sviderskaya, E. V., Theos, A. C., Lamoreux, M. L., Di Pietro, S. M., Starcevic, M., Bennett, D. C., Dell'Angelica, E. C., Raposo, G. and Marks, M. S. (2007). BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol Biol Cell 18(3): 768-780.
  10. Di Pietro, S. M., Falcon-Perez, J. M., Tenza, D., Setty, S. R., Marks, M. S., Raposo, G. and Dell'Angelica, E. C. (2006). BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Mol Biol Cell 17(9): 4027-4038.
  11. Robertson, S. E., Setty, S. R., Sitaram, A., Marks, M. S., Lewis, R. E. and Chou, M. M. (2006). Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Mol Biol Cell 17(2): 645-657.
  12. Yoshino, A., Setty, S. R., Poynton, C., Whiteman, E. L., Saint-Pol, A., Burd, C. G., Johannes, L., Holzbaur, E. L., Koval, M., McCaffery, J. M. and Marks, M. S. (2005). tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre. J Cell Sci 118(Pt 10): 2279-2293.
  13. Burd, C. G., Strochlic, T. I. and Gangi Setty, S. R. (2004). Arf-like GTPases: not so Arf-like after all. Trends Cell Biol 14(12): 687-694.
  14. Setty, S. R., Strochlic, T. I., Tong, A. H., Boone, C. and Burd, C. G. (2004). Golgi targeting of ARF-like GTPase Arl3p requires its Na-acetylation and the integral membrane protein Sys1p. Nat Cell Biol 6(5): 414-419.
  15. Setty, S. R., Shin, M. E., Yoshino, A., Marks, M. S. and Burd, C. G. (2003). Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3. Curr Biol 13(5): 401-404.
  16. Subba Rao, G., Bachhawat, A. K. and Gupta, C. M. (2002). Two-hybrid-based analysis of protein-protein interactions of the yeast multidrug resistance protein, Pdr5p. Funct Integr Genomics 1(6): 357-366.
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