Education
Ph.D. in Microbiology, University of Adelaide, South Australia Australia, 1992
Current position
Professor in Microbiology, Flinders University, South Australia
Publications (since 2005)
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Li, L., Hassan, K. A., Brown, M. H. and Paulsen, I. T. (2016). Rapid multiplexed phenotypic screening identifies drug resistance functions for three novel efflux pumps in Acinetobacter baumannii. J Antimicrob Chemother 71(5): 1223-1232.
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Chen, M. M. S., Boardman, W. S. J., Smith, I., Goodman, A. E. and Brown, M. H. (2015). Characterisation of -lactam resistance mediated by blaZ in staphylococci recovered from captive and wild wallabies. Journal of Global Antibiotic Resistance 3:184-189.
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Giles, S. K., Eijkelkamp, B. A., Stroeher, U. H. and Brown, M. H. (2015). Identification of genes involved in pellicle formation in Acinetobacter baumannii ATCC 17978. BMC Microbiology 15:116.
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Antiabong, J. F., Ball, A. S. and Brown, M. H. (2015). The effects of iron limitation and cell density on prokaryotic metabolism and gene expression: Excerpts from Fusobacterium necrophorum strain 774 (sheep isolate). Gene 563(1): 94-102.
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Iscla, I., Wray, R., Blount, P., Larkins-Ford, J., Conery, A. L., Ausubel, F. M., Ramu, S., Kavanagh, A., Huang, J. X., Blaskovich, M. A., Cooper, M. A., Obregon-Henao, A., Orme, I., Tjandra, E. S., Stroeher, U. H., Brown, M. H., Macardle, C., van Holst, N., Ling Tong, C., Slattery, A. D., Gibson, C. T., Raston, C. L. and Boulos, R. A. (2015). A new antibiotic with potent activity targets MscL. J Antibiot (Tokyo) 68(7): 453-462.
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Tong, C. L., Stroeher, U. H., Brown, M. H. and Raston, C. L. (2015). Continuous flow vortex fluidic synthesis of silica xerogel as a delivery vehicle for curcumin. RSC Advances 5:7953-7958.
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Leterme, S. C., Jendyk, J-G., Ellis, A. V., Brown, M. H. and Kildea, T. (2014). Annual phytoplankton dynamics in the Gulf Saint Vincent, South Australian, in 2011. Oceanologia 56:757-778.
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Jendyk, J-G., Hemraj, D. A., Brown, M. H., Ellis, A. V. and Leterme, S. C. (2014). Environmental variability and phytoplankton dynamics in a South Australian inverse estuary. Continental Shelf Research.
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Eijkelkamp, B. A., Stroeher, U. H., Hassan, K. A., Paulsen, I. T. and Brown, M. H. (2014). Comparative analysis of surface-exposed virulence factors of Acinetobacter baumannii. BMC Genomics 15: 1020.
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Fluman, N., Adler, J., Rotenberg, S. A., Brown, M. H. and Bibi, E. (2014). Export of a single drug molecule in two transport cycles by a multidrug efflux pump. Nat Commun 5: 4615.
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Chen, M. M. S., Boardman, W..S..J., Smith, I., Goodman, A.E. and Brown, M. H. (2014). Nasal colonisation of Staphylococcus spp among captive and free-ranging wallabies in South Australia. Journal of Veterinary Science and Medical Diagnosis 3:2.
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Balzano, S., Le Lan C., Ellis, A. V., Compass, H., Newton, K., Jamieson, T., Brown, M. H. and Leterme, S. C. (2014). Evaluation of transparent exopolymer particles and microbial communities found post UV-light, multimedia and cartridge filtration pre-treatment in a SWRO plant. Desalination and Water Treatment.
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Hassan, K. A., Jackson, S. M., Penesyan, A., Patching, S. G., Tetu, S. G., Eijkelkamp, B. A., Brown, M. H., Henderson, P. J. and Paulsen, I. T. (2013). Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins. Proc Natl Acad Sci U S A 110(50): 20254-20259.
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Antiabong, J. F., Boardman, W., Adetutu, E. M., Brown, M. H. and Ball, A. S. (2013). Does anaerobic bacterial antibiosis decrease fungal diversity in oral necrobacillosis disease? Res Vet Sci 95(3): 1012-1020.
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Antiabong, J. F., Boardman, W., Smith, I., Brown, M. H., Ball, A. and Goodman, A. E. (2013). Detection of Fusobacterium necrophorum leukotoxin (lkta) gene sequence in the oral cavity of captive macropods. Journal of Veterinary Science and Medical Diagnosis 2:2.
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Antiabong, J. F., Boardman, W., Moore, R. B., Brown, M. H. and Ball, A. S. (2013). The oral microbial community of gingivitis and lumpy jaw in captive macropods. Res Vet Sci 95(3): 996-1005.
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Smith, R. J., Jeffries, T. C., Roudnew, B., Speck, P. G., Fitch, A. J., Seymour, J. R., Newton, K., Brown, M. H. and Mitchell, J. G. (2013). Confined aquifers as viral reservoirs. Environmental Microbiology Reports. 5:725-730.
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Antiabong, J. F., Jardine, D., Boardman, W., Brown, M. H. and Ball, A. S. (2013). A molecular ecological approach to the detection and designation of the etiological agents of a model polymicrobial disease. J Vet Diagn Invest 25(4): 467-472.
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Eijkelkamp, B. A., Stroeher, U. H., Hassan, K. A., Elbourne, L. D., Paulsen, I. T. and Brown, M. H. (2013). H-NS plays a role in expression of Acinetobacter baumannii virulence features. Infect Immun 81(7): 2574-2583.
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Farrugia, D. N., Elbourne, L. D., Hassan, K. A., Eijkelkamp, B. A., Tetu, S. G., Brown, M. H., Shah, B. S., Peleg, A. Y., Mabbutt, B. C. and Paulsen, I. T. (2013). The complete genome and phenome of a community-acquired Acinetobacter baumannii. PLoS One 8(3): e58628.
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Antiabong, J. F., Boardman, W., Smith, I., Brown, M. H., Ball, A. S. and Goodman, A. E. (2013). A molecular survey of a captive wallaby population for periodontopathogens and the co-incidence of Fusobacterium necrophorum subspecies necrophorum with periodontal diseases. Vet Microbiol 163(3-4): 335-343.
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La Vars, S. M., Johnston, M. R., Hayles, J., Gascooke, J. R., Brown, M. H., Leterme, S. C. and Ellis, A. V. (2013). 29Si{1H} CP-MAS NMR comparison and ATR-FTIR spectroscopic analysis of the diatoms Chaetoceros muelleri and Thalassiosira pseudonana grown at different salinities. Anal Bioanal Chem 405(10): 3359-3365.
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Antiabong, J. F., Boardman, W., Smith, I., Brown, M. H., Ball, A. S. and Goodman, A. E. (2013). "Cycliplex PCR" confirmation of Fusobacterium necrophorum isolates from captive wallabies: a rapid and accurate approach. Anaerobe 19: 44-49.
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Leterme, S. C., Prime, E., Mitchell, J., Brown, M. H. and Ellis, A. V. (2013). Diatom adaptability to environmental change: a case study of two Cocconeis species from high-salinity areas. Diatom Research 28:29-35.
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Smith, R. J., Jeffries, T. C., Roudnew, B., Fitch, A. J., Seymour, J. R., Delpin, M. W., Newton, K., Brown, M. H. and Mitchell, J. G. (2012). Metagenomic comparison of microbial communities inhabiting confined and unconfined aquifer ecosystems. Environ Microbiol 14(1): 240-253.
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Eijkelkamp, B. A., Stroeher, U. H., Hassan, K. A., Papadimitrious, M. S., Paulsen, I. T. and Brown, M. H. (2011). Adherence and motility characteristics of clinical Acinetobacter baumannii isolates. FEMS Microbiol Lett 323(1): 44-51.
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Baltzer, S. A. and Brown, M. H. (2011). Antimicrobial peptides: promising alternatives to conventional antibiotics. J Mol Microbiol Biotechnol 20(4): 228-235.
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Eijkelkamp, B. A., Hassan, K. A., Paulsen, I. T. and Brown, M. H. (2011). Development of a high-throughput cloning strategy for characterization of Acinetobacter baumannii drug transporter proteins. J Mol Microbiol Biotechnol 20(4): 211-219.
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Hassan, K. A., Brzoska, A. J., Wilson, N. L., Eijkelkamp, B. A., Brown, M. H. and Paulsen, I. T. (2011). Roles of DHA2 family transporters in drug resistance and iron homeostasis in Acinetobacter spp. J Mol Microbiol Biotechnol 20(2): 116-124.
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Eijkelkamp, B. A., Hassan, K. A., Paulsen, I. T. and Brown, M. H. (2011). Investigation of the human pathogen Acinetobacter baumannii under iron limiting conditions. BMC Genomics 12: 126.
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Peters, K. M., Brooks, B. E., Schumacher, M. A., Skurray. R. A. Brennan, R. G. and Brown, M. H. (2011). A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. PLoS ONE 6:e15974
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Merlino, J. and Brown, M. H. (2010). Biocides in the health industry. Microbiology Australia 31:158
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Hassan, K. A., Baltzer, S. A., Paulsen, I. T. and Brown, M. H. (2010). Pumping out biocides- cause for concern. Microbiology Australia 31:178-181.
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Ni, L., Jensen, S. O., Ky Tonthat, N., Berg, T., Kwong, S. M., Guan, F. H., Brown, M. H., Skurray, R. A., Firth, N. and Schumacher, M. A. (2009). The Staphylococcus aureus pSK41 plasmid-encoded ArtA protein is a master regulator of plasmid transmission genes and contains a RHH motif used in alternate DNA-binding modes. Nucleic Acids Res 37(20): 6970-6983.
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Peters, K. M., Sharbeen, G., Theis, T., Skurray, R. A. and Brown, M. H. (2009). Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription. Biochemistry 48(41): 9794-9800.
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Ho, A. Y. Y., Day, D. A. Brown, M. H. and Marc, J. (2009). Arabidopsis phospholipase Dδ: initiator of cytoskeleton-mediated signalling to fundamental cellular processes. Functional Plant Biology 36:1-9.
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Hassan, K. A., Xu, Z., Watkins, R. E., Brennan, R. G., Skurray, R. A. and Brown, M. H. (2009). Optimized production and analysis of the staphylococcal multidrug efflux protein QacA. Protein Expr Purif 64(2): 118-124.
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Wu, J., Hassan, K. A., Skurray, R. A. and Brown, M. H. (2008). Functional analyses reveal an important role for tyrosine residues in the staphylococcal multidrug efflux protein QacA. BMC Microbiol 8: 147.
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Peters, K. M., Schuman, J. T., Skurray, R. A., Brown, M. H., Brennan, R. G. and Schumacher, M. A. (2008). QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization. Biochemistry 47(31): 8122-8129.
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Hassan, K. A., Souhani, T., Skurray, R. A. and Brown, M. H. (2008). Analysis of tryptophan residues in the staphylococcal multidrug transporter QacA reveals long-distance functional associations of residues on opposite sides of the membrane. J Bacteriol 190(7): 2441-2449.
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Hassan, K. A., Skurray, R. A. and Brown, M. H. (2007). Transmembrane helix 12 of the Staphylococcus aureus multidrug transporter QacA lines the bivalent cationic drug binding pocket. J Bacteriol 189(24): 9131-9134.
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Theis, T., Skurray, R. A. and Brown, M. H. (2007). Identification of suitable internal controls to study expression of a Staphylococcus aureus multidrug resistance system by quantitative real-time PCR. J Microbiol Methods 70(2): 355-362.
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Hassan, K. A., Skurray, R. A. and Brown, M. H. (2007). Active export proteins mediating drug resistance in staphylococci. J Mol Microbiol Biotechnol 12(3-4): 180-196.
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Hassan, K. A., Robinson, K. L., Smith, A. N., Gibson, J. H., Skurray, R. A. and Brown, M. H. (2006). Glycine-rich transmembrane helix 10 in the staphylococcal tetracycline transporter TetA(K) lines a solvent-accessible channel. Biochemistry 45(51): 15661-15669.
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Hassan, K. A., Galea, M., Wu, J., Mitchell, B. A., Skurray, R. A. and Brown, M. H. (2006). Functional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacA. FEMS Microbiol Lett 263(1): 76-85.
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Saidijam, M., Benedetti, G., Ren, Q., Xu, Z., Hoyle, C. J., Palmer, S. L., Ward, A., Bettaney, K. E., Szakonyi, G., Meuller, J., Morrison, S., Pos, M. K., Butaye, P., Walravens, K., Langton, K., Herbert, R. B., Skurray, R. A., Paulsen, I. T., O'Reilly, J., Rutherford, N. G., Brown, M. H., Bill, R. M. and Henderson, P. J. (2006). Microbial drug efflux proteins of the major facilitator superfamily. Curr Drug Targets 7(7): 793-811.
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Bayer, A. S., Kupferwasser, L. I., Brown, M. H., Skurray, R. A., Grkovic, S., Jones, T., Mukhopadhay, K. and Yeaman, M. R. (2006). Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity. Antimicrob Agents Chemother 50(7): 2448-2454.
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Xu, Z., O'Rourke, B. A., Skurray, R. A. and Brown, M. H. (2006). Role of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacA. J Biol Chem 281(2): 792-799.