Alexander D. Bershadsky
  • Mechanobiology Institute, National University of Singapore, Singapore
Research fields
  • Molecular biology
Personal information


Ph.D. in Cell Biology-Experimental Oncology, Cancer Research Center of the USSR Academy of Med. Science, 1974

Current position

Senior Principal Research Scientist, Mechanobiology Institute, Singapore, National University of Singapore
The Joseph Moss Professor of Biomedical Research, Department of Molecular Cell Biology Weizmann Institute of Science

Publications (since 2005)

  1. Shao, X., Kawauchi, K., Shivashankar, G. V. and Bershadsky, A. D. (2015). Novel localization of formin mDia2: importin beta-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope. Biol Open 4(11): 1569-1575.
  2. Hu, S., Tee, Y. H., Kabla, A., Zaidel-Bar, R., Bershadsky, A. and Hersen, P. (2015). Structured illumination microscopy reveals focal adhesions are composed of linear subunits. Cytoskeleton (Hoboken) 72(5): 235-245.
  3. Shao, X., Li, Q., Mogilner, A., Bershadsky, A. D. and Shivashankar, G. V. (2015). Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim. Proc Natl Acad Sci U S A 112(20): E2595-2601.
  4. Tee, Y. H., Shemesh, T., Thiagarajan, V., Hariadi, R. F., Anderson, K. L., Page, C., Volkmann, N., Hanein, D., Sivaramakrishnan, S., Kozlov, M. M. and Bershadsky, A. D. (2015). Cellular chirality arising from the self-organization of the actin cytoskeleton. Nat Cell Biol 17(4): 445-457.
  5. Low, B. C., Pan, C. Q., Shivashankar, G. V., Bershadsky, A., Sudol, M. and Sheetz, M. (2014). YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth. FEBS Lett 588(16): 2663-2670.
  6. Yu, C. H., Rafiq, N. B., Krishnasamy, A., Hartman, K. L., Jones, G. E., Bershadsky, A. D. and Sheetz, M. P. (2013). Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces. Cell Rep 5(5): 1456-1468.
  7. Luo, W., Yu, C. H., Lieu, Z. Z., Allard, J., Mogilner, A., Sheetz, M. P. and Bershadsky, A. D. (2013). Analysis of the local organization and dynamics of cellular actin networks. J Cell Biol 202(7): 1057-1073.
  8. Shemesh, T., Bershadsky, A. D. and Kozlov, M. M. (2012). Physical model for self-organization of actin cytoskeleton and adhesion complexes at the cell front. Biophys J 102(8): 1746-1756.
  9. Siton, O., Ideses, Y., Albeck, S., Unger, T., Bershadsky, A. D., Gov, N. S. and Bernheim-Groswasser, A. (2011). Cortactin releases the brakes in actin- based motility by enhancing WASP-VCA detachment from Arp2/3 branches. Curr Biol 21(24): 2092-2097.
  10. Bershadsky, A. D. and Kozlov, M. M. (2011). Crawling cell locomotion revisited. Proc Natl Acad Sci U S A 108(51): 20275-20276.
  11. Prager-Khoutorsky, M., Lichtenstein, A., Krishnan, R., Rajendran, K., Mayo, A., Kam, Z., Geiger, B. and Bershadsky, A. D. (2011). Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing. Nat Cell Biol 13(12): 1457-1465.
  12. Zilberman, Y., Alieva, N. O., Miserey-Lenkei, S., Lichtenstein, A., Kam, Z., Sabanay, H. and Bershadsky, A. (2011). Involvement of the Rho-mDia1 pathway in the regulation of Golgi complex architecture and dynamics. Mol Biol Cell 22(16): 2900-2911.
  13. Wolfenson, H., Bershadsky, A., Henis, Y. I. and Geiger, B. (2011). Actomyosin-generated tension controls the molecular kinetics of focal adhesions. J Cell Sci 124(Pt 9): 1425-1432.
  14. Zhang, X., Tee, Y. H., Heng, J. K., Zhu, Y., Hu, X., Margadant, F., Ballestrem, C., Bershadsky, A., Griffiths, G. and Yu, H. (2010). Kinectin-mediated endoplasmic reticulum dynamics supports focal adhesion growth in the cellular lamella. J Cell Sci 123(Pt 22): 3901-3912.
  15. Lim, C. T., Bershadsky, A. and Sheetz, M. P. (2010). Mechanobiology. J R Soc Interface 7 Suppl 3: S291-293.
  16. Zilberman, Y., Ballestrem, C., Carramusa, L., Mazitschek, R., Khochbin, S. and Bershadsky, A. (2009). Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6. J Cell Sci 122(Pt 19): 3531-3541.
  17. Shemesh, T., Verkhovsky, A. B., Svitkina, T. M., Bershadsky, A. D. and Kozlov, M. M. (2009). Role of focal adhesions and mechanical stresses in the formation and progression of the lamellipodium-lamellum interface [corrected]. Biophys J 97(5): 1254-1264.
  18. Wolfenson, H., Henis, Y. I., Geiger, B. and Bershadsky, A. D. (2009). The heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions. Cell Motil Cytoskeleton 66(11): 1017-1029.
  19. Cinnamon, Y., Feine, O., Hochegger, H., Bershadsky, A. and Brandeis, M. (2009). Cellular contractility requires ubiquitin mediated proteolysis. PLoS One 4(7): e6155.
  20. Geiger, B., Spatz, J. P. and Bershadsky, A. D. (2009). Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol 10(1): 21-33.
  21. Alexandrova, A. Y., Arnold, K., Schaub, S., Vasiliev, J. M., Meister, J. J., Bershadsky, A. D. and Verkhovsky, A. B. (2008). Comparative dynamics of retrograde actin flow and focal adhesions: formation of nascent adhesions triggers transition from fast to slow flow. PLoS One 3(9): e3234.
  22. Shtutman, M., Chausovsky, A., Prager-Khoutorsky, M., Schiefermeier, N., Boguslavsky, S., Kam, Z., Fuchs, E., Geiger, B., Borisy, G. G. and Bershadsky, A. D. (2008). Signaling function of alpha-catenin in microtubule regulation. Cell Cycle 7(15): 2377-2383.
  23. Carramusa, L., Ballestrem, C., Zilberman, Y. and Bershadsky, A. D. (2007). Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions. J Cell Sci 120(Pt 21): 3870-3882.
  24. Boguslavsky, S., Grosheva, I., Landau, E., Shtutman, M., Cohen, M., Arnold, K., Feinstein, E., Geiger, B. and Bershadsky, A. (2007). p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin. Proc Natl Acad Sci U S A 104(26): 10882-10887.
  25. Prager-Khoutorsky, M., Goncharov, I., Rabinkov, A., Mirelman, D., Geiger, B. and Bershadsky, A. D. (2007). Allicin inhibits cell polarization, migration and division via its direct effect on microtubules. Cell Motil Cytoskeleton 64(5): 321-337.
  26. Bershadsky, A., Kozlov, M. and Geiger, B. (2006). Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize. Curr Opin Cell Biol 18(5): 472-481.
  27. Grosheva, I., Vittitow, J. L., Goichberg, P., Gabelt, B. T., Kaufman, P. L., Borras, T., Geiger, B. and Bershadsky, A. D. (2006). Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells. Exp Eye Res 82(6): 945-958.
  28. Levy, Y., Auslender, S., Eisenstein, M., Vidavski, R. R., Ronen, D., Bershadsky, A. D. and Zick, Y. (2006). It depends on the hinge: a structure-functional analysis of galectin-8, a tandem-repeat type lectin. Glycobiology 16(6): 463-476.
  29. Ballestrem, C., Erez, N., Kirchner, J., Kam, Z., Bershadsky, A. and Geiger, B. (2006). Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J Cell Sci 119(Pt 5): 866-875.
  30. Gabelt, B. T., Hu, Y., Vittitow, J. L., Rasmussen, C. R., Grosheva, I., Bershadsky, A. D., Geiger, B., Borras, T. and Kaufman, P. L. (2006). Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments. Exp Eye Res 82(6): 935-944.
  31. Bershadsky, A. D., Ballestrem, C., Carramusa, L., Zilberman, Y., Gilquin, B., Khochbin, S., Alexandrova, A. Y., Verkhovsky, A. B., Shemesh, T. and Kozlov, M. M. (2006). Assembly and mechanosensory function of focal adhesions: experiments and models. Eur J Cell Biol 85(3-4): 165-173.
  32. Shemesh, T., Bershadsky, A. D. and Kozlov, M. M. (2005). Force-driven polymerization in cells: actin filaments and focal adhesions. J Phys Condens Matter 17(47): S3913-3928.
  33. Shemesh, T., Otomo, T., Rosen, M. K., Bershadsky, A. D. and Kozlov, M. M. (2005). A novel mechanism of actin filament processive capping by formin: solution of the rotation paradox. J Cell Biol 170(6): 889-893.
  34. Shemesh, T., Geiger, B., Bershadsky, A. D. and Kozlov, M. M. (2005). Focal adhesions as mechanosensors: a physical mechanism. Proc Natl Acad Sci U S A 102(35): 12383-12388.
  35. Erez, N., Bershadsky, A. and Geiger, B. (2005). Signaling from adherens-type junctions. Eur J Cell Biol 84(2-3): 235-244.
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.