Javier M. Di Noia
  • Institut de Recherches Cliniques de Montréal, Canada
Research fields
  • Immunology
Personal information


Ph.D., University of Buenos Aires

Current position

Associate Research Professor, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada, Chercheur agrégé, Université de Montréal, Département of medicine


  1. Methot, S. P. and Di Noia, J. M. (2015). Pharmacological manipulation of AID. Oncotarget 6(29): 26550-26551.
  2. Di Noia, J. M. (2015). Molecular biology: Unequal opportunity during class switching. Nature 525(7567): 44-45.
  3. Montamat-Sicotte, D., Litzler, L. C., Abreu, C., Safavi, S., Zahn, A., Orthwein, A., Muschen, M., Oppezzo, P., Munoz, D. P. and Di Noia, J. M. (2015). HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur J Immunol 45(8): 2365-2376.
  4. Methot, S. P., Litzler, L. C., Trajtenberg, F., Zahn, A., Robert, F., Pelletier, J., Buschiazzo, A., Magor, B. G. and Di Noia, J. M. (2015). Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm. J Exp Med 212(4): 581-596.
  5. Collin, R., Dugas, V., Chabot-Roy, G., Salem, D., Zahn, A., Di Noia, J. M., Rauch, J. and Lesage, S. (2015). Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12. J Autoimmun 58: 90-99.
  6. Zahn, A., Eranki, A. K., Patenaude, A. M., Methot, S. P., Fifield, H., Cortizas, E. M., Foster, P., Imai, K., Durandy, A., Larijani, M., Verdun, R. E. and Di Noia, J. M. (2014). Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination. Proc Natl Acad Sci U S A 111(11): E988-997.
  7. Yu, H., Pak, H., Hammond-Martel, I., Ghram, M., Rodrigue, A., Daou, S., Barbour, H., Corbeil, L., Hebert, J., Drobetsky, E., Masson, J. Y., Di Noia, J. M. and Affar el, B. (2014). Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc Natl Acad Sci U S A 111(1): 285-290.
  8. Cortizas, E. M., Zahn, A., Hajjar, M. E., Patenaude, A. M., Di Noia, J. M. and Verdun, R. E. (2013). Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination. J Immunol 191(11): 5751-5763.
  9. Munoz, D. P., Lee, E. L., Takayama, S., Coppe, J. P., Heo, S. J., Boffelli, D., Di Noia, J. M. and Martin, D. I. (2013). Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc Natl Acad Sci U S A 110(32): E2977-2986.
  10. Zahn, A., Daugan, M., Safavi, S., Godin, D., Cheong, C., Lamarre, A. and Di Noia, J. M. (2013). Separation of function between isotype switching and affinity maturation in vivo during acute immune responses and circulating autoantibodies in UNG-deficient mice. J Immunol 190(12): 5949-5960.
  11. Campo, V. A., Patenaude, A. M., Kaden, S., Horb, L., Firka, D., Jiricny, J. and Di Noia, J. M. (2013). MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils. Nucleic Acids Res 41(5): 3032-3046.
  12. Hu, Y., Ericsson, I., Torseth, K., Methot, S. P., Sundheim, O., Liabakk, N. B., Slupphaug, G., Di Noia, J. M., Krokan, H. E. and Kavli, B. (2013). A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching. J Mol Biol 425(2): 424-443.
  13. Orthwein, A. and Di Noia, J. M. (2012). Activation induced deaminase: how much and where? Semin Immunol 24(4): 246-254.
  14. Orthwein, A., Zahn, A., Methot, S. P., Godin, D., Conticello, S. G., Terada, K. and Di Noia, J. M. (2012). Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. EMBO J 31(3): 679-691.
  15. De Marchi, C. R., Di Noia, J. M., Frasch, A. C., Amato Neto, V., Almeida, I. C. and Buscaglia, C. A. (2011). Evaluation of a recombinant Trypanosoma cruzi mucin-like antigen for serodiagnosis of Chagas' disease. Clin Vaccine Immunol 18(11): 1850-1855.
  16. Orthwein, A., Patenaude, A. M., Affar el, B., Lamarre, A., Young, J. C. and Di Noia, J. M. (2010). Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. J Exp Med 207(12): 2751-2765.
  17. Patenaude, A. M. and Di Noia, J. M. (2010). The mechanisms regulating the subcellular localization of AID. Nucleus 1(4): 325-331.
  18. Patenaude, A. M., Orthwein, A., Hu, Y., Campo, V. A., Kavli, B., Buschiazzo, A. and Di Noia, J. M. (2009). Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nat Struct Mol Biol 16(5): 517-527.
  19. Di Noia, J. M., Williams, G. T., Chan, D. T., Buerstedde, J. M., Baldwin, G. S. and Neuberger, M. S. (2007). Dependence of antibody gene diversification on uracil excision. J Exp Med 204(13): 3209-3219.
  20. Di Noia, J. M. and Neuberger, M. S. (2007). Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem 76: 1-22.
  21. Buscaglia, C. A., Campo, V. A., Frasch, A. C. and Di Noia, J. M. (2006). Trypanosoma cruzi surface mucins: host-dependent coat diversity. Nat Rev Microbiol 4(3): 229-236.
  22. Di Noia, J. M., Rada, C. and Neuberger, M. S. (2006). SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair. EMBO J 25(3): 585-595.
  23. Campo, V. A., Buscaglia, C. A., Di Noia, J. M. and Frasch, A. C. (2006). Immunocharacterization of the mucin-type proteins from the intracellular stage of Trypanosoma cruzi. Microbes Infect 8(2): 401-409.
  24. Neuberger, M. S., Di Noia, J. M., Beale, R. C., Williams, G. T., Yang, Z. and Rada, C. (2005). Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation. Nat Rev Immunol 5(2): 171-178.
  25. Rada, C., Di Noia, J. M. and Neuberger, M. S. (2004). Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol Cell 16(2): 163-171.
  26. Buscaglia, C. A., Campo, V. A., Di Noia, J. M., Torrecilhas, A. C., De Marchi, C. R., Ferguson, M. A., Frasch, A. C. and Almeida, I. C. (2004). The surface coat of the mammal-dwelling infective trypomastigote stage of Trypanosoma cruzi is formed by highly diverse immunogenic mucins. J Biol Chem 279(16): 15860-15869.
  27. Di Noia, J. M. and Neuberger, M. S. (2004). Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination. Eur J Immunol 34(2): 504-508.
  28. Campo, V., Di Noia, J. M., Buscaglia, C. A., Aguero, F., Sanchez, D. O. and Frasch, A. C. (2004). Differential accumulation of mutations localized in particular domains of the mucin genes expressed in the vertebrate host stage of Trypanosoma cruzi. Mol Biochem Parasitol 133(1): 81-91.
  29. Neuberger, M. S., Harris, R. S., Di Noia, J. and Petersen-Mahrt, S. K. (2003). Immunity through DNA deamination. Trends Biochem Sci 28(6): 305-312.
  30. Buscaglia, C. A. and Di Noia, J. M. (2003). Trypanosoma cruzi clonal diversity and the epidemiology of Chagas' disease. Microbes Infect 5(5): 419-427.
  31. Aguero, F., Campo, V., Cremona, L., Jager, A., Di Noia, J. M., Overath, P., Sanchez, D. O. and Frasch, A. C. (2002). Gene discovery in the freshwater fish parasite Trypanosoma carassii: identification of trans-sialidase-like and mucin-like genes. Infect Immun 70(12): 7140-7144.
  32. Di Noia, J. and Neuberger, M. S. (2002). Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419(6902): 43-48.
  33. Di Noia, J. M., Buscaglia, C. A., De Marchi, C. R., Almeida, I. C. and Frasch, A. C. (2002). A Trypanosoma cruzi small surface molecule provides the first immunological evidence that Chagas' disease is due to a single parasite lineage. J Exp Med 195(4): 401-413.
  34. Argibay, P. F., Di Noia, J. M., Hidalgo, A., Mocetti, E., Barbich, M., Lorenti, A. S., Bustos, D., Tambutti, M., Hyon, S. H., Frasch, A. C. and Sanchez, D. O. (2002). Trypanosoma cruzi surface mucin TcMuc-e2 expressed on higher eukaryotic cells induces human T cell anergy, which is reversible. Glycobiology 12(1): 25-32.
  35. Pollevick, G. D., Di Noia, J. M., Salto, M. L., Lima, C., Leguizamon, M. S., de Lederkremer, R. M. and Frasch, A. C. (2000). Trypanosoma cruzi surface mucins with exposed variant epitopes. J Biol Chem 275(36): 27671-27680.
  36. Di Noia, J. M., D'Orso, I., Sanchez, D. O. and Frasch, A. C. (2000). AU-rich elements in the 3'-untranslated region of a new mucin-type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency. J Biol Chem 275(14): 10218-10227.
  37. Di Noia, J. M., D'Orso, I., Aslund, L., Sanchez, D. O. and Frasch, A. C. (1998). The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions. J Biol Chem 273(18): 10843-10850.
  38. Di Noia, J. M., Pollevick, G. D., Xavier, M. T., Previato, J. O., Mendoca-Previato, L., Sanchez, D. O. and Frasch, A. C. (1996). High diversity in mucin genes and mucin molecules in Trypanosoma cruzi. J Biol Chem 271(50): 32078-32083.
  39. Di Noia, J. M., Sanchez, D. O. and Frasch, A. C. (1995). The protozoan Trypanosoma cruzi has a family of genes resembling the mucin genes of mammalian cells. J Biol Chem 270(41): 24146-24149.
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.