Colin C. Anderson
  • Medical Microbiology and Immunology,Surgery, and Alberta Diabetes and Transplant Institutes, University of Alberta, Canada
Research focus
  • Immunology
Personal information


Ph.D. in Philosophy in Microbiology and Immunology, University of Western Ontario, London, ON, 1990

Current position

Director, Division of Surgical Research (2014-present)
Full Professor, Department of Surgery, University of Alberta (2014-present)
Director, Cellular Immunology Core, Alberta Diabetes Institute (2008-present)
Member, Alberta Diabetes Institute, University of Alberta (2004-present)
Adjunct Professor in the Department of Medical, Microbiology & Immunology, University of Alberta (2002-present)

Publications (since 2007)

  1. Ellestad, K. K. and Anderson, C. C. (2016). In vitro T Cell proliferation and Treg suppression assay with celltrace violet. Bio-protocol 6(1): e1698.
  2. Momtazi, M., Ding, J., Kwan, P., Anderson, C. C., Honardoust, D., Goekjian, S. and Tredget, E. E. (2015). Morphologic and Histologic Comparison of Hypertrophic Scar in Nude Mice, T-Cell Receptor, and Recombination Activating Gene Knockout Mice. Plast Reconstr Surg 136(6): 1192-1204.
  3. Ellestad, K. K., Thangavelu, G., Ewen, C. L., Boon, L. and Anderson, C. C. (2014). PD-1 is not required for natural or peripherally induced regulatory T cells: Severe autoimmunity despite normal production of regulatory T cells. Eur J Immunol 44(12): 3560-3572. (Funded by CIHR)
  4. Anderson, C. C. (2014). Application of central immunologic concepts to cancer: helping T cells and B cells become intolerant of tumors. Eur J Immunol 44(7): 1921-1924. (Invited peer reviewed commentary)
  5. Smolarchuk, C., Zhu, L. F., Chan, W. F. and Anderson, C. C. (2014). T cells generated in the absence of a thoracic thymus fail to establish homeostasis. Eur J Immunol 44(8): 2263-2273.
  6. Thangavelu, G., Gill, R. G., Boon, L., Ellestad, K. K. and Anderson, C. C. (2013). Control of in vivo collateral damage generated by T cell immunity. J Immunol 191(4): 1686-1691. (Funded by CIHR)
  7. Mold, J. E. and Anderson, C. C. (2013). A discussion of immune tolerance and the layered immune system hypothesis. Chimerism 4(3): 62-70. (Invited, peer reviewed, debate)
  8. Al-Adra, D. P. and Anderson, C. C. (2013). Toward minimal conditioning protocols for allogeneic chimerism in tolerance resistant recipients. Chimerism 4(1): 23-25.
  9. Momtazi, M., Kwan, P., Ding, J., Anderson, C. C., Honardoust, D., Goekjian, S. and Tredget, E. E. (2013). A nude mouse model of hypertrophic scar shows morphologic and histologic characteristics of human hypertrophic scar. Wound Repair Regen 21(1): 77-87.
  10. Al-Adra, D. P., Pawlick, R., Shapiro, A. M. and Anderson, C. C. (2012). Targeting cells causing split tolerance allows fully allogeneic islet survival with minimal conditioning in NOD mixed chimeras. Am J Transplant 12(12): 3235-3245. (Funded by: CDA and ECE)
  11. Anderson, C. C. (2012). Comment on: Ten experiments that would make a difference in understanding immune mechanisms. Cell Mol Life Sci 69(3): 413-416; author reply 417-422. (Invited commentary)
  12. Al-Adra, D. P. and Anderson, C. C. (2011). Mixed chimerism and split tolerance: mechanisms and clinical correlations. Chimerism 2(4): 89-101. (Review, peer reviewed)
  13. Al-Adra, D. P.*, Chan, W. F.* and Anderson, C. C. (2011). Nonobese diabetic natural killer cells: a barrier to allogeneic chimerism that can be reduced by rapamycin. Transplantation 92(9): 977-984. (*Co-first authors) (Funded by: CDA)
  14. Gadi, V. K., Nelson, J. L., Guthrie, K. A., Anderson, C. C., Boespflug, N. D., Redinger, J. W., Paul, B., Dinyari, P. and Shapiro, A. M. (2011). Soluble donor DNA and islet injury after transplantation. Transplantation 92(5): 607-611.
  15. Thangavelu, G. and Anderson, C. C. (2011). An essential role for programmed death-1 in the control of autoimmunity: implications for the future of hematopoietic stem cell transplantation. Future Oncol 7(8): 929-932. (Invited editorial; not peer reviewed)
  16. Thangavelu, G., Parkman, J. C., Ewen, C. L., Uwiera, R. R., Baldwin, T. A. and Anderson, C. C. (2011). Programmed death-1 is required for systemic self-tolerance in newly generated T cells during the establishment of immune homeostasisa. J Autoimmun 36(3-4): 301-312. (Funded by JDRF and CIHR)
  17. Thangavelu, G. and Anderson, C. C. (2011). Divide and conquer: Blocking graft versus host but not graft versus leukemia T cells with agonist BTLA co-inhibitory signals. Chimerism 2(1): 29-32. (Invited, peer reviewed commentary)
  18. Thangavelu, G., Murphy, K. M., Yagita, H., Boon, L. and Anderson, C. C. (2011). The role of co-inhibitory signals in spontaneous tolerance of weakly mismatched transplants. Immunobiology 216(8): 918-924. (Funded by CIHR and JDRF)
  19. Thangavelu, G., Smolarchuk, C. and Anderson, C. C. (2010). Co-inhibitory molecules: Controlling the effectors or controlling the controllers? Self Nonself 1(2): 77-88. (Review/hypothesis; peer reviewed)
  20. Anderson, C. C. (2009). On the sorting of the repertoire: an analysis of Cohn's challenge to integrity (Dembic), Round 2. Scand J Immunol 70(4): 321-325. (Invited, peer reviewed commentary)
  21. Truong, W., Hancock, W. W., Plester, J. C., Merani, S., Rayner, D. C., Thangavelu, G., Murphy, K. M., Anderson, C. C.* and Shapiro, A. M.* (2009). BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice. J Leukoc Biol 86(1): 41-51. *Co-senior author (equal contributions)
  22. Anderson, C. C. (2009). Placing regulatory T cells into global theories of immunity: an analysis of Cohn's challenge to integrity (Dembic). Scand J Immunol 69(4): 306-309. (Invited, peer reviewed commentary)
  23. West, L. J. and Anderson, C. C. (2009). Comment on 'Tolerance versus immunosuppression: a perspective'. Am J Transplant 9(2): 435-436. (Peer reviewed commentary/letter to the editor)
  24. Merani, S., Pawlick, R. L., Edgar, R. L., Toso, C., Emamaullee, J., Anderson, C. C. and Shapiro, A. M. (2009). Protein kinase C inhibitor, AEB-071, acts complementarily with cyclosporine to prevent islet rejection in rats. Transplantation 87(1): 59-65.
  25. Toso, C., Edgar, R., Pawlick, R., Emamaullee, J., Merani, S., Dinyari, P., Mueller, T. F., Shapiro, A. M.* and Anderson, C. C.*(2009). Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantation. Transpl Int 22(2): 182-191. (*Co-senior author)
  26. Chan, W. F., Razavy, H. and Anderson, C. C. (2008). Differential susceptibility of allogeneic targets to indirect CD4 immunity generates split tolerance. J Immunol 181(7): 4603-4612. (Funded by CIHR)
  27. Chan, W. F., Razavy, H., Luo, B., Shapiro, A. M. and Anderson, C. C. (2008). Development of either split tolerance or robust tolerance along with humoral tolerance to donor and third-party alloantigens in nonmyeloablative mixed chimeras. J Immunol 180(8): 5177-5186.
  28. Truong, W., Plester, J. C., Hancock, W. W., Kaye, J., Merani, S., Murphy, K. M., Murphy, T. L., Anderson, C. C.* and Shapiro, A. M.* (2007). Negative and positive co-signaling with anti-BTLA (PJ196) and CTLA4Ig prolongs islet allograft survival. Transplantation 84(10): 1368-1372. (*Co-corresponding senior author)
  29. Truong, W., Plester, J. C., Hancock, W. W., Merani, S., Murphy, T. L., Murphy, K. M., Kaye, J., Anderson, C. C.* and Shapiro, A. M.* (2007). Combined coinhibitory and costimulatory modulation with anti-BTLA and CTLA4Ig facilitates tolerance in murine islet allografts. Am J Transplant 7(12): 2663-2674. (*Co-corresponding/senior author)
  30. Chan, W. F., Perez-Diez, A., Razavy, H. and Anderson, C. C. (2007). The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits. Biol Direct 2: 10.
  31. Luo, B., Chan, W. F., Shapiro, A. M. and Anderson, C. C. (2007). Non-myeloablative mixed chimerism approaches and tolerance, a split decision. Eur J Immunol 37(5): 1233-1242. This paper was highlighted in the ‘In this issue’ section and a figure from it was featured on the journal cover.
  32. Perez-Diez, A., Joncker, N. T., Choi, K., Chan, W. F., Anderson, C. C., Lantz, O. and Matzinger, P. (2007). CD4 cells can be more efficient at tumor rejection than CD8 cells. Blood 109(12): 5346-5354. See also- Commentary, pp. 5070-5071 in the same issue.
  33. Luo, B., Chan, W. F., Lord, S. J., Nanji, S. A., Rajotte, R. V., Shapiro, A. M. and Anderson, C. C. (2007). Diabetes induces rapid suppression of adaptive immunity followed by homeostatic T-cell proliferation. Scand J Immunol 65(1): 22-31. (*Co-first authors) Note: This paper won the Viking prize, a top paper prize for 2007 from the Scand J Immunol. (Funded by CIHR, NIH and ECE)
  34. Truong, W., Emamaullee, J. A., Merani, S., Anderson, C. C., and Shapiro A. M. J. (2007). Chronic exposure of human islets to the sphingosine-1-phosphate receptor agonist FTY720 does not impair function in vitro or in vivo. Am J Transplant 7: 2031-2038.
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