David Santamaría
  • Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Spain
Research fields
  • Cancer biology
Personal information


Ph.D., Universidad Autónoma, Madrid, Spain, 1999

Current position

Staff Scientist, CNIO, Madrid (Experimental Oncology group; PI: Mariano Barbacid) (2003-today)


* Co-corresponding authors

  1. Viera, A., Alsheimer, M., Gómez, R., Berenguer, I., Ortega, S., Symonds, C. E., Santamaría, D., Benavente, R. and Suja, J. A. (2015). CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase. J Cell Sci 128(1): 88-99.
  2. Trakala, M., Rodríguez-Acebes, S., Maroto, M., Symonds, C. E., Santamaría, D., Ortega, S., Barbacid, M., Méndez, J. and Malumbres, M. (2015). Functional reprogramming of polyploidization in megakaryocytes. Dev Cell 32(2): 155-167.
  3. Cerqueira, A., Martín, A., Symonds, C. E., Odajima, J., Dubus, P., Barbacid, M. and Santamaría, D. (2014). Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors. Mol Cell Biol 34(8): 1452-1459.
  4. Ambrogio, C., Carmona, F. J., Vidal, A., Falcone, M., Nieto, P., Romero, O. A., Puertas, S., Vizoso, M., Nadal, E., Poggio, T., Sánchez-Céspedes, M., Esteller, M., Mulero, F., Voena, C., Chiarle, R., Barbacid, M., Santamaría, D.* and Villanueva, A.* (2014). Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts. Cancer Res 74(21): 5978-5988.
  5. Ambrogio, C., Stern, P., Scuoppo, C., Kranz, H., Barbacid, M. and Santamaría, D. (2014). Lentiviral-based approach for the validation of cancer therapeutic targets in vivo. Biotechniques 57(4): 179, 181-177. 7
  6. Ganuza, M. and Santamaría, D. (2012). Cdk7: open questions beyond the prevailing model. Cell Cycle 11(19): 3519-3520.
  7. Ganuza, M., Sáiz-Ladera, C., Cañamero, M., Gómez, G., Schneider, R., Blasco, M. A., Pisano, D., Paramio, J. M., Santamaría, D.* and Barbacid, M.* (2012). Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J 31(11): 2498-2510.
  8. Santamaría, D. and Malumbres, M. (2011). Tumor suppression by Spinophilin. Cell Cycle 10(17): 2831-2832.
  9. Hennessy, E. J., Sheedy, F. J., Santamaría, D., Barbacid, M. and O'Neill, L. A. (2011). Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6. J Biol Chem 286(29): 25531-25539.
  10. Blasco, R. B., Francoz, S., Santamaría, D., Cañamero, M., Dubus, P., Charron, J., Baccarini, M. and Barbacid, M. (2011). c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell 19(5): 652-663.
  11. Beukelaers, P., Vandenbosch, R., Caron, N., Nguyen, L., Belachew, S., Moonen, G., Kiyokawa, H., Barbacid, M., Santamaría, D. and Malgrange, B. (2011). Cdk6-dependent regulation of G(1) length controls adult neurogenesis. Stem Cells 29(4): 713-724.
  12. Puyol, M., Martín, A., Dubus, P., Mulero, F., Pizcueta, P., Khan, G., Guerra, C., Santamaría, D. and Barbacid, M. (2010). A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 18(1): 63-73.
  13. Cerqueira, A., Santamaría, D., Martínez-Pastor, B., Cuadrado, M., Fernández-Capetillo, O. and Barbacid, M. (2009). Overall Cdk activity modulates the DNA damage response in mammalian cells. J Cell Biol 187(6): 773-780.
  14. Santamaría, D., Barriere, C., Cerqueira, A., Hunt, S., Tardy, C., Newton, K., Cáceres, J. F., Dubus, P., Malumbres, M. and Barbacid, M. (2007). Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448(7155): 811-815.
  15. Barrière, C., Santamaría, D., Cerqueira, A., Galán, J., Martín, A., Ortega, S., Malumbres, M., Dubus, P. and Barbacid, M. (2007). Mice thrive without Cdk4 and Cdk2. Mol Oncol 1(1): 72-83.
  16. Santamaría, D. and Ortega, S. (2006). Cyclins and CDKS in development and cancer: lessons from genetically modified mice. Front Biosci 11: 1164-1188.
  17. Barbacid, M., Ortega, S., Sotillo, R., Odajima, J., Martín, A., Santamaría, D., Dubus, P. and Malumbres, M. (2005). Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases. Cold Spring Harb Symp Quant Biol 70: 233-240.
  18. Malumbres, M., Sotillo, R., Santamaría, D., Galán, J., Cerezo, A., Ortega, S., Dubus, P. and Barbacid, M.* (2004). Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118(4): 493-504.
  19. Clay-Farrace, L., Pelizon, C., Santamaría, D., Pines, J. and Laskey, R. A. (2003). Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1. EMBO J 22(3): 704-712.
  20. Santamaría, D., Hernández, P., Martínez-Robles, M. L., Krimer, D. B. and Schvartzman, J. B. (2000). Premature termination of DNA replication in plasmids carrying two inversely oriented ColE1 origins. J Mol Biol 300(1): 75-82.
  21. Santamaría, D., Viguera, E., Martínez-Robles, M. L., Hyrien, O., Hernández, P., Krimer, D. B. and Schvartzman, J. B. (2000). Bi-directional replication and random termination. Nucleic Acids Res 28(10): 2099-2107.
  22. Santamaría, D., de la Cueva, G., Martínez-Robles, M. L., Krimer, D. B., Hernández, P. and Schvartzman, J. B. (1998). DnaB helicase is unable to dissociate RNA-DNA hybrids. Its implication in the polar pausing of replication forks at ColE1 origins. J Biol Chem 273(50): 33386-33396.
  23. Vanegas, N., Castañeda, V., Santamaría, D., Hernández, P., Schvartzman, J. B. and Krimer, D. B. (1997). Cloning, sequencing and expression in MEL cells of a cDNA encoding the mouse ribosomal protein S5. Biochim Biophys Acta 1357(1): 1-4.
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