Lee J. Sweetlove
  • Department of Plant Sciences, University of Oxford, UK
Research focus
  • Plant science
Personal information


Ph.D. in Plant Biochemistry, University of Cambridge, 1995

Current position

Professor of Plant Sciences, Department of Plant Sciences, University of Oxford, UK

Publications (since 2010)

  1. Cheung, C. Y., Ratcliffe, R. G. and Sweetlove, L. J. (2015). A method of accounting for enzyme costs in flux balance analysis reveals alternative pathways and metabolite stores in an illuminated Arabidopsis leaf. Plant Physiol 169(3): 1671-1682.
  2. Snowden, C. J., Thomas, B., Baxter, C. J., Smith, J. A. and Sweetlove, L. J. (2015). A tonoplast Glu/Asp/GABA exchanger that affects tomato fruit amino acid composition. Plant J 81(5): 651-660.
  3. Schwarzländer, M., Wagner, S., Ermakova, Y. G., Belousov, V. V., Radi, R., Beckman, J. S., Buettner, G. R., Demaurex, N., Duchen, M. R., Forman, H. J., Fricker, M. D., Gems, D., Halestrap, A. P., Halliwell, B., Jakob, U., Johnston, I. G., Jones, N. S., Logan, D. C., Morgan, B., Muller, F. L., Nicholls, D. G., Remington, S. J., Schumacker, P. T., Winterbourn, C. C., Sweetlove, L. J., Meyer, A. J., Dick, T. P. and Murphy, M. P. (2014). The 'mitoflash' probe cpYFP does not respond to superoxide. Nature 514(7523): E12-14.
  4. Cheung, C. Y., Poolman, M. G., Fell, D. A., Ratcliffe, R. G. and Sweetlove, L. J. (2014). A Diel Flux Balance Model Captures Interactions between Light and Dark Metabolism during Day-Night Cycles in C3 and Crassulacean Acid Metabolism Leaves. Plant Physiol 165(2): 917-929.
  5. Biais, B., Benard, C., Beauvoit, B., Colombie, S., Prodhomme, D., Menard, G., Bernillon, S., Gehl, B., Gautier, H., Ballias, P., Mazat, J. P., Sweetlove, L., Genard, M. and Gibon, Y. (2014). Remarkable reproducibility of enzyme activity profiles in tomato fruits grown under contrasting environments provides a roadmap for studies of fruit metabolism. Plant Physiol 164(3): 1204-1221.
  6. Masakapalli, S. K., Ritala, A., Dong, L., van der Krol, A. R., Oksman-Caldentey, K. M., Ratcliffe, R. G. and Sweetlove, L. J. (2014). Metabolic flux phenotype of tobacco hairy roots engineered for increased geraniol production. Phytochemistry 99: 73-85.
  7. Nunes-Nesi, A., Florian, A., Howden, A., Jahnke, K., Timm, S., Bauwe, H., Sweetlove, L. J., and Fernie, A. R. (2014). Is there a metabolic requirement for photorespiratory enzyme activities in heterotrophic tissues? Mol Plant 7: 248-251.
  8. Gehl, B., Lee, C. P., Bota, P., Blatt, M. R. and Sweetlove, L. J. (2014). An Arabidopsis stomatin-like protein affects mitochondrial respiratory supercomplex organization. Plant Physiol 164(3): 1389-1400.
  9. O'Leary, B., Preston, G. M. and Sweetlove, L. J. (2014). Increased beta-cyanoalanine nitrilase activity improves cyanide tolerance and assimilation in Arabidopsis. Mol Plant 7(1): 231-243.
  10. Cheung, C. Y., Williams, T. C., Poolman, M. G., Fell, D. A., Ratcliffe, R. G. and Sweetlove, L. J. (2013). A method for accounting for maintenance costs in flux balance analysis improves the prediction of plant cell metabolic phenotypes under stress conditions. Plant J 75(6): 1050-1061.
  11. Finkemeier, I., Konig, A. C., Heard, W., Nunes-Nesi, A., Pham, P. A., Leister, D., Fernie, A. R. and Sweetlove, L. J. (2013). Transcriptomic analysis of the role of carboxylic acids in metabolite signaling in Arabidopsis leaves. Plant Physiol 162(1): 239-253.
  12. Morgan, M. J., Osorio, S., Gehl, B., Baxter, C. J., Kruger, N. J., Ratcliffe, R. G., Fernie, A. R. and Sweetlove, L. J. (2013). Metabolic engineering of tomato fruit organic acid content guided by biochemical analysis of an introgression line. Plant Physiol 161(1): 397-40 7.
  13. Wirtz, M., Beard, K. F., Lee, C. P., Boltz, A., Schwarzlander, M., Fuchs, C., Meyer, A. J., Heeg, C., Sweetlove, L. J., Ratcliffe, R. G. and Hell, R. (2012). Mitochondrial cysteine synthase complex regulates O-acetylserine biosynthesis in plants. J Biol Chem 287(33): 27941-27947.
  14. Schwärzlander, M., Logan, D. C., Johnston, I. G., Jones, N. S., Meyer, A. J., Fricker, M. D. and Sweetlove, L. J. (2012). Pulsing of membrane potential in individual mitochondria: a stress-induced mechanism to regulate respiratory bioenergetics in Arabidopsis. Plant Cell 24(3): 1188-1201.
  15. Schwärzlander, M., Konig, A. C., Sweetlove, L. J. and Finkemeier, I. (2012). The impact of impaired mitochondrial function on retrograde signalling: a meta-analysis of transcriptomic responses. J Exp Bot 63(4): 1735-1750.
  16. Williams, T. C., Sweetlove, L. J. and Ratcliffe, R. G. (2011). Capturing metabolite channeling in metabolic flux phenotypes. Plant Physiol 157(3): 981-984.
  17. Schwarzlander, M., Logan, D. C., Fricker, M. D. and Sweetlove, L. J. (2011). The circularly permuted yellow fluorescent protein cpYFP that has been used as a superoxide probe is highly responsive to pH but not superoxide in mitochondria: implications for the existence of superoxide 'flashes'. Biochem J 437(3): 381-387.
  18. Finkemeier, I., Laxa, M., Miguet, L., Howden, A. J. and Sweetlove, L. J. (2011). Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis. Plant Physiol 155(4): 1779-1790.
  19. Obata, T., Matthes, A., Koszior, S., Lehmann, M., Araujo, W. L., Bock, R., Sweetlove, L. J. and Fernie, A. R. (2011). Alteration of mitochondrial protein complexes in relation to metabolic regulation under short-term oxidative stress in Arabidopsis seedlings. Phytochemistry 72(10): 1081-1091.
  20. Howden, A. J., Salek, M., Miguet, L., Pullen, M., Thomas, B., Knight, M. R. and Sweetlove, L. J. (2011). The phosphoproteome of Arabidopsis plants lacking the oxidative signal-inducible1 (OXI1) protein kinase. New Phytol 190(1): 49-56.
  21. Lehmann, M., Laxa, M., Sweetlove, L. J., Fernie, A. R. and Obata, T. (2012). Metabolic recovery of Arabidopsis thaliana roots following cessation of oxidative stress. Metabolomics 8(1): 143-153.
  22. Williams, T. C., Poolman, M. G., Howden, A. J., Schwarzlander, M., Fell, D. A., Ratcliffe, R. G. and Sweetlove, L. J. (2010). A genome-scale metabolic model accurately predicts fluxes in central carbon metabolism under stress conditions. Plant Physiol 154(1): 311-323.
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