Education
Ph.D. in Plant Biochemistry, University of Cambridge, 1995
Current position
Professor of Plant Sciences, Department of Plant Sciences, University of Oxford, UK
Publications (since 2010)
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Cheung, C. Y., Ratcliffe, R. G. and Sweetlove, L. J. (2015). A method of accounting for enzyme costs in flux balance analysis reveals alternative pathways and metabolite stores in an illuminated Arabidopsis leaf. Plant Physiol 169(3): 1671-1682.
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Snowden, C. J., Thomas, B., Baxter, C. J., Smith, J. A. and Sweetlove, L. J. (2015). A tonoplast Glu/Asp/GABA exchanger that affects tomato fruit amino acid composition. Plant J 81(5): 651-660.
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Schwarzländer, M., Wagner, S., Ermakova, Y. G., Belousov, V. V., Radi, R., Beckman, J. S., Buettner, G. R., Demaurex, N., Duchen, M. R., Forman, H. J., Fricker, M. D., Gems, D., Halestrap, A. P., Halliwell, B., Jakob, U., Johnston, I. G., Jones, N. S., Logan, D. C., Morgan, B., Muller, F. L., Nicholls, D. G., Remington, S. J., Schumacker, P. T., Winterbourn, C. C., Sweetlove, L. J., Meyer, A. J., Dick, T. P. and Murphy, M. P. (2014). The 'mitoflash' probe cpYFP does not respond to superoxide. Nature 514(7523): E12-14.
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Cheung, C. Y., Poolman, M. G., Fell, D. A., Ratcliffe, R. G. and Sweetlove, L. J. (2014). A Diel Flux Balance Model Captures Interactions between Light and Dark Metabolism during Day-Night Cycles in C3 and Crassulacean Acid Metabolism Leaves. Plant Physiol 165(2): 917-929.
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Biais, B., Benard, C., Beauvoit, B., Colombie, S., Prodhomme, D., Menard, G., Bernillon, S., Gehl, B., Gautier, H., Ballias, P., Mazat, J. P., Sweetlove, L., Genard, M. and Gibon, Y. (2014). Remarkable reproducibility of enzyme activity profiles in tomato fruits grown under contrasting environments provides a roadmap for studies of fruit metabolism. Plant Physiol 164(3): 1204-1221.
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Masakapalli, S. K., Ritala, A., Dong, L., van der Krol, A. R., Oksman-Caldentey, K. M., Ratcliffe, R. G. and Sweetlove, L. J. (2014). Metabolic flux phenotype of tobacco hairy roots engineered for increased geraniol production. Phytochemistry 99: 73-85.
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Nunes-Nesi, A., Florian, A., Howden, A., Jahnke, K., Timm, S., Bauwe, H., Sweetlove, L. J., and Fernie, A. R. (2014). Is there a metabolic requirement for photorespiratory enzyme activities in heterotrophic tissues? Mol Plant 7: 248-251.
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Gehl, B., Lee, C. P., Bota, P., Blatt, M. R. and Sweetlove, L. J. (2014). An Arabidopsis stomatin-like protein affects mitochondrial respiratory supercomplex organization. Plant Physiol 164(3): 1389-1400.
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O'Leary, B., Preston, G. M. and Sweetlove, L. J. (2014). Increased beta-cyanoalanine nitrilase activity improves cyanide tolerance and assimilation in Arabidopsis. Mol Plant 7(1): 231-243.
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Cheung, C. Y., Williams, T. C., Poolman, M. G., Fell, D. A., Ratcliffe, R. G. and Sweetlove, L. J. (2013). A method for accounting for maintenance costs in flux balance analysis improves the prediction of plant cell metabolic phenotypes under stress conditions. Plant J 75(6): 1050-1061.
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Finkemeier, I., Konig, A. C., Heard, W., Nunes-Nesi, A., Pham, P. A., Leister, D., Fernie, A. R. and Sweetlove, L. J. (2013). Transcriptomic analysis of the role of carboxylic acids in metabolite signaling in Arabidopsis leaves. Plant Physiol 162(1): 239-253.
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Morgan, M. J., Osorio, S., Gehl, B., Baxter, C. J., Kruger, N. J., Ratcliffe, R. G., Fernie, A. R. and Sweetlove, L. J. (2013). Metabolic engineering of tomato fruit organic acid content guided by biochemical analysis of an introgression line. Plant Physiol 161(1): 397-40 7.
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Wirtz, M., Beard, K. F., Lee, C. P., Boltz, A., Schwarzlander, M., Fuchs, C., Meyer, A. J., Heeg, C., Sweetlove, L. J., Ratcliffe, R. G. and Hell, R. (2012). Mitochondrial cysteine synthase complex regulates O-acetylserine biosynthesis in plants. J Biol Chem 287(33): 27941-27947.
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Schwärzlander, M., Logan, D. C., Johnston, I. G., Jones, N. S., Meyer, A. J., Fricker, M. D. and Sweetlove, L. J. (2012). Pulsing of membrane potential in individual mitochondria: a stress-induced mechanism to regulate respiratory bioenergetics in Arabidopsis. Plant Cell 24(3): 1188-1201.
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Schwärzlander, M., Konig, A. C., Sweetlove, L. J. and Finkemeier, I. (2012). The impact of impaired mitochondrial function on retrograde signalling: a meta-analysis of transcriptomic responses. J Exp Bot 63(4): 1735-1750.
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Williams, T. C., Sweetlove, L. J. and Ratcliffe, R. G. (2011). Capturing metabolite channeling in metabolic flux phenotypes. Plant Physiol 157(3): 981-984.
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Schwarzlander, M., Logan, D. C., Fricker, M. D. and Sweetlove, L. J. (2011). The circularly permuted yellow fluorescent protein cpYFP that has been used as a superoxide probe is highly responsive to pH but not superoxide in mitochondria: implications for the existence of superoxide 'flashes'. Biochem J 437(3): 381-387.
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Finkemeier, I., Laxa, M., Miguet, L., Howden, A. J. and Sweetlove, L. J. (2011). Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis. Plant Physiol 155(4): 1779-1790.
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Obata, T., Matthes, A., Koszior, S., Lehmann, M., Araujo, W. L., Bock, R., Sweetlove, L. J. and Fernie, A. R. (2011). Alteration of mitochondrial protein complexes in relation to metabolic regulation under short-term oxidative stress in Arabidopsis seedlings. Phytochemistry 72(10): 1081-1091.
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Howden, A. J., Salek, M., Miguet, L., Pullen, M., Thomas, B., Knight, M. R. and Sweetlove, L. J. (2011). The phosphoproteome of Arabidopsis plants lacking the oxidative signal-inducible1 (OXI1) protein kinase. New Phytol 190(1): 49-56.
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Lehmann, M., Laxa, M., Sweetlove, L. J., Fernie, A. R. and Obata, T. (2012). Metabolic recovery of Arabidopsis thaliana roots following cessation of oxidative stress. Metabolomics 8(1): 143-153.
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Williams, T. C., Poolman, M. G., Howden, A. J., Schwarzlander, M., Fell, D. A., Ratcliffe, R. G. and Sweetlove, L. J. (2010). A genome-scale metabolic model accurately predicts fluxes in central carbon metabolism under stress conditions. Plant Physiol 154(1): 311-323.