Chiaki Takahashi Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Japan
1 protocol

Fengkai Li Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Japan
1 protocol

Shunsuke Kitajima
  • Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Japan
Research focus
  • Cancer biology
  • 1 Author merit


Ph.D., Kyoto University Graduate School of Medicine, 2006

Current position

Dana-Farber Cancer Institute, Harvard Medical School (2015-present)


  1. Okahashi, N., Kohno, S., Kitajima, S., Matsuda, F., Takahashi, C. and Shimizu, H. (2015). Metabolic characterization of cultured mammalian cells by mass balance analysis, tracer labeling experiments and computer-aided simulations. J Biosci Bioeng 120(6): 725-731.
  2. Kitajima, S., Kohno, S., Kondoh, A., Sasaki, N., Nishimoto, Y., Li, F., Abdallah Mohammed, M. S., Muranaka, H., Nagatani, N., Suzuki, M., Kido, Y. and Takahashi, C. (2015). Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts. Stem Cells 33(5): 1657-1669.
  3. Shamma, A., Suzuki, M., Hayashi, N., Kobayashi, M., Sasaki, N., Nishiuchi, T., Doki, Y., Okamoto, T., Kohno, S., Muranaka, H., Kitajima, S., Yamamoto, K. and Takahashi, C. (2013). ATM mediates pRB function to control DNMT1 protein stability and DNA methylation. Mol Cell Biol 33(16): 3113-3124.
  4. Takahashi, C., Sasaki, N. and Kitajima, S. (2012). Twists in views on RB functions in cellular signaling, metabolism and stem cells. Cancer Sci 103(7): 1182-1188.
  5. Taura, M., Suico, M. A., Koyama, K., Komatsu, K., Miyakita, R., Matsumoto, C., Kudo, E., Kariya, R., Goto, H., Kitajima, S., Takahashi, C., Shuto, T., Nakao, M., Okada, S. and Kai, H. (2012). Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells. Mol Cell Biol 32(8): 1581-1590.
  6. Kitajima, S., Miki, T., Takegami, Y., Kido, Y., Noda, M., Hara, E., Shamma, A. and Takahashi, C. (2011). Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling. Oncogene 30(6): 737-750.
  7. Miki, T., Shamma, A., Kitajima, S., Takegami, Y., Noda, M., Nakashima, Y., Watanabe, K. and Takahashi, C. (2010). The ss1-integrin-dependent function of RECK in physiologic and tumor angiogenesis. Mol Cancer Res 8(5): 665-676.
  8. Shamma, A., Takegami, Y., Miki, T., Kitajima, S., Noda, M., Obara, T., Okamoto, T. and Takahashi, C. (2009). Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation. Cancer Cell 15(4): 255-269.
  9. Muraguchi, T., Takegami, Y., Ohtsuka, T., Kitajima, S., Chandana, E. P., Omura, A., Miki, T., Takahashi, R., Matsumoto, N., Ludwig, A., Noda, M. and Takahashi, C. (2007). RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity. Nat Neurosci 10(7): 838-845.
1 Protocol published
Generation of Mouse Thyroid Calcitonin-producing Cell Tumors from Primary Mouse Tumors
Authors:  Shunsuke Kitajima, Fengkai Li and Chiaki Takahashi, date: 12/20/2015, view: 7457, Q&A: 0
Medullary thyroid cancers (MTCs) are derived from calcitonin-producing cells (C cells) of neuroendocrine origin. Rb heterozygous mice develop low-grade C cell adenocarcinoma following biallelic inactivation of the Rb tumor ...
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