Education
Ph.D. in Biochemistry and Molecular Biophysics, University of Pennsylvania, 2000
Current position
Associate Professor, Department of Biological Chemistry, University of California, Los Angeles (2011-present)
Publications (since 2005)
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Barr, I., Weitz, S. H., Atkin, T., Hsu, P., Karayiorgou, M., Gogos, J. A., Weiss, S. and Guo, F. (2015). Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency. Chem Biol 22(6): 793-802.
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Barr, I. and Guo, F. (2014). Primary microRNA processing assay reconstituted using recombinant Drosha and DGCR8. Methods Mol Biol 1095: 73-86.
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Weitz, S. H., Gong, M., Barr, I., Weiss, S. and Guo, F. (2014). Processing of microRNA primary transcripts requires heme in mammalian cells. Proc Natl Acad Sci U S A 111(5): 1861-1866.
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Chin, R. M., Fu, X., Pai, M. Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V. S., Monsalve, G. C., Hu, E., Whelan, S. A., Wang, J. X., Jung, G., Solis, G. M., Fazlollahi, F., Kaweeteerawat, C., Quach, A., Nili, M., Krall, A. S., Godwin, H. A., Chang, H. R., Faull, K. F., Guo, F., Jiang, M., Trauger, S. A., Saghatelian, A., Braas, D., Christofk, H. R., Clarke, C. F., Teitell, M. A., Petrascheck, M., Reue, K., Jung, M. E., Frand, A. R. and Huang, J. (2014). The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510(7505): 397-401.
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Quick-Cleveland, J., Jacob, J. P., Weitz, S. H., Shoffner, G., Senturia, R. and Guo, F. (2014). The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin. Cell Rep 7(6): 1994-2005.
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Barr, I., Smith, A. T., Chen, Y., Senturia, R., Burstyn, J. N. and Guo, F. (2012). Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing. Proc Natl Acad Sci U S A 109(6): 1919-1924.
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Meer, E. J., Wang, D. O., Kim, S., Barr, I., Guo, F. and Martin, K. C. (2012). Identification of a cis-acting element that localizes mRNA to synapses. Proc Natl Acad Sci U S A 109(12): 4639-4644.
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Gong, M., Chen, Y., Senturia, R., Ulgherait, M., Faller, M. and Guo, F. (2012). Caspases cleave and inhibit the microRNA processing protein DiGeorge Critical Region 8. Protein Sci 21(6): 797-808.
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Senturia, R., Laganowsky, A., Barr, I., Scheidemantle, B. D. and Guo, F. (2012). Dimerization and heme binding are conserved in amphibian and starfish homologues of the microRNA processing protein DGCR8. PLoS One 7(7): e39688.
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Barr, I., Smith, A. T., Senturia, R., Chen, Y., Scheidemantle, B. D., Burstyn, J. N. and Guo, F. (2011). DiGeorge critical region 8 (DGCR8) is a double-cysteine-ligated heme protein. J Biol Chem 286(19): 16716-16725.
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Januszyk, K., Fleissner, M. R., Atchabahian, L., Shieh, F. K., Altenbach, C., Martin, S. L., Guo, F., Hubbell, W. L. and Clubb, R. T. (2011). Site-directed spin labeling electron paramagnetic resonance study of the ORF1 protein from a mouse L1 retrotransposon. Protein Sci 20(7): 1231-1243.
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Senturia, R., Faller, M., Yin, S., Loo, J. A., Cascio, D., Sawaya, M. R., Hwang, D., Clubb, R. T. and Guo, F. (2010). Structure of the dimerization domain of DiGeorge critical region 8. Protein Sci 19(7): 1354-1365.
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Faller, M., Toso, D., Matsunaga, M., Atanasov, I., Senturia, R., Chen, Y., Zhou, Z. H. and Guo, F. (2010). DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures. RNA 16(8): 1570-1583.
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Miallau, L., Faller, M., Chiang, J., Arbing, M., Guo, F., Cascio, D. and Eisenberg, D. (2009). Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem 284(1): 276-283.
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Faller, M. and Guo, F. (2008). MicroRNA biogenesis: there's more than one way to skin a cat. Biochim Biophys Acta 1779(11): 663-667. (Invited review article)
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Wang, Q., Barr, I., Guo, F. and Lee, C. (2008). Evidence of a novel RNA secondary structure in the coding region of HIV-1 pol gene. RNA 14(12): 2478-2488.
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Ghosh, K., Guo, F. and Van Duyne, G. D. (2007). Synapsis of loxP sites by Cre recombinase. J Biol Chem 282(33): 24004-24016.
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Faller, M., Matsunaga, M., Yin, S., Loo, J. A. and Guo, F. (2007). Heme is involved in microRNA processing. Nat Struct Mol Biol 14(1): 23-29.
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Guo, F., Gooding, A. R. and Cech, T. R. (2006). Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. RNA 12(3): 387-395.
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Ghosh, K., Lau, C. K., Guo, F., Segall, A. M. and Van Duyne, G. D. (2005). Peptide trapping of the Holliday junction intermediate in Cre-loxP site-specific recombination. J Biol Chem 280(9): 8290-8299.
Invited book chapters and an edited book
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Guo, F. (2012). Drosha and DGCR8 in microRNA biogenesis. In: Guo, F. and Tamanoi, F. (eds). The enzymes: eukaryotic RNases and their partners in RAN degradation and biogenesis, Part B 1st edition. Elsevier Inc.
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Guo, F. (2011). Heme and microRNA biogenesis. In: Zhang, L. (ed). Heme biology: the secret life of heme in regulating diverse biological processes 1st edition. World Scientific.