Ian Barr Department of Biological Chemistry, David Geffen School Medicine, UCLA, USA

Ian Barr

Department of Biological Chemistry, David Geffen School of Medicine, UCLA, USA

Research fields

Biochemistry

Personal information

Education

Ph.D. in Biological Chemistry, University of California, Los Angeles, 2012

Current position

Postdoctoral Researcher, University of California, Berkeley (2013-present)

Publications

Rui, Z., Li, X., Zhu, X., Liu, J., Domigan, B., Barr, I., Cate, J. H. and Zhang, W. (2014). Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase. Proceedings of the National Academy of Sciences 111(51): 18237-18242.
Latham, J. A., Iavarone, A. T., Barr, I., Juthani, P. V. and Klinman, J. P. (2015). PqqD is a novel peptide chaperone that forms a ternary complex with the radical S-adenosylmethionine protein PqqE in the pyrroloquinoline quinone biosynthetic pathway. J Biol Chem 290(20): 12908-12918.
Barr, I., Weitz, S. H., Atkin, T., Hsu, P., Karayiorgou, M., Gogos, J. A., Weiss, S. and Guo, F. (2015). Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency. Chem Biol 22(6): 793-802.
Barr, I. and Guo, F. (2014). Primary microRNA processing assay reconstituted using recombinant Drosha and DGCR8. Methods Mol Biol 1095: 73-86.
Weitz, S. H., Gong, M., Barr, I., Weiss, S. and Guo, F. (2014). Processing of microRNA primary transcripts requires heme in mammalian cells. Proc Natl Acad Sci U S A 111(5): 1861-1866.
Senturia, R., Laganowsky, A., Barr, I., Scheidemantle, B. D. and Guo, F. (2012). Dimerization and heme binding are conserved in amphibian and starfish homologues of the microRNA processing protein DGCR8. PLoS One 7(7): e39688.
Meer, E. J., Wang, D. O., Kim, S., Barr, I., Guo, F. and Martin, K. C. (2012). Identification of a cis-acting element that localizes mRNA to synapses. Proc Natl Acad Sci U S A 109(12): 4639-4644.
Barr, I., Smith, A. T., Chen, Y., Senturia, R., Burstyn, J. N. and Guo, F. (2012). Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing. Proc Natl Acad Sci U S A 109(6): 1919-1924.
Barr, I., Smith, A. T., Senturia, R., Chen, Y., Scheidemantle, B. D., Burstyn, J. N. and Guo, F. (2011). DiGeorge critical region 8 (DGCR8) is a double-cysteine-ligated heme protein. J Biol Chem 286(19): 16716-16725.
Wang, Q., Barr, I., Guo, F. and Lee, C. (2008). Evidence of a novel RNA secondary structure in the coding region of HIV-1 pol gene. RNA 14(12): 2478-2488.