Matilda F. Chan
  • University of California
Research fields
  • Molecular biology
Personal information


M.D./Ph.D. in Biochemistry, Keck/University of Southern California, 2002

Current position

Assistant Professor, Ophthalmology, School of Medicine, University of California, San Francisco, USA


  1. Chan, M. F., Li, J., Bertrand, A., Casbon, A. J., Lin, J. H., Maltseva, I. and Werb, Z. (2013). Protective effects of matrix metalloproteinase-12 following corneal injury. J Cell Sci 126(Pt 17): 3948-3960.
  2. Maltseva, I., Chan, M., Kalus, I., Dierks, T. and Rosen, S. D. (2013). The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One 8(8): e69642.
  3. Dalmon, C., Porco, T. C., Lietman, T. M., Prajna, N. V., Prajna, L., Das, M. R., Kumar, J. A., Mascarenhas, J., Margolis, T. P., Whitcher, J. P., Jeng, B. H., Keenan, J. D., Chan, M. F., McLeod, S. D. and Acharya, N. R. (2012). The clinical differentiation of bacterial and fungal keratitis: a photographic survey. Invest Ophthalmol Vis Sci 53(4): 1787-1791.
  4. Oldenburg, C. E., Keenan, J. D., Cevallos, V., Chan, M. F., Acharya, N. R., Gaynor, B. D., McLeod, S. D., Esterberg, E. J., Porco, T. C. and Lietman, T. M. (2011). Microbiological cure times in acanthamoeba keratitis. Eye (Lond) 25(9): 1155-1160.
  5. Chan, M. F., Sack, R., Quigley, D. A., Sathe, S., Vijmasi, T., Li, S., Holsclaw, D., Strauss, E. C. and McNamara, N. A. (2011). Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. Optom Vis Sci 88(8): 1005-1009.
  6. Hu, A. Y., Strauss, E. C., Holland, G. N., Chan, M. F., Yu, F. and Margolis, T. P. (2010). Late varicella-zoster virus dendriform keratitis in patients with histories of herpes zoster ophthalmicus. Am J Ophthalmol 149(2): 214-220 e213.
  7. Rutar, T., Chan, M. F., Acharya, N. R. and Naseri, A. (2007). Cicatrising conjunctivitis due to paraneoplastic pemphigoid. Br J Ophthalmol 91(11): 1562-1563.
  8. Sappington, R. M., Chan, M. and Calkins, D. J. (2006). Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest Ophthalmol Vis Sci 47(7): 2932-2942.
  9. Liang, G.*, Chan, M. F.*, Tomigahara, Y., Tsai, Y. C., Gonzales, F. A., Li, E., Laird, P. W. and Jones, P. A. (2002). Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol 22(2): 480-491. (*Both authors contributed equally to this work)
  10. Chan, M. F., van Amerongen, R., Nijjar, T., Cuppen, E., Jones, P. A. and Laird, P. W. (2001). Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol 21(22): 7587-7600.
  11. Simoneau, A. R., Spruck, C. H., 3rd, Gonzalez-Zulueta, M., Gonzalgo, M. L., Chan, M. F., Tsai, Y. C., Dean, M., Steven, K., Horn, T. and Jones, P. A. (1996). Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. Cancer Res 56(21): 5039-5043.

Review articles

  1. Chan, M. F., Liang, G. and Jones, P. A. (2000). Relationship between transcription and DNA methylation. Curr Top Microbiol Immunol 249: 75-86.

Books and chapters

  1. Chan, M. F. and Ching, S. T. (2007). Infectious mononucleosis (Epstein-Barr Virus). In: Roy, F. H., Fraunfelder, F. T. and Fraunfelder, F. W. (eds). Current ocular therapy, 6 th Edition. London: Elsevier Limited.
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