Marie-France Cesbron-Delauw
  • Université Grenoble Alpes, France
Research focus
  • Microbiology
Personal information


Ph.D. in Molecular Parasitology, Université Libre de Bruxelles, 1986

Current position

Director of Research 1st class CNRS, Team Leader at Laboratoire Adaptation et Pathogénie des Microorganismes, UMR5163 CNRS-Université Grenoble 1, France

Publications (since 2006)

  1. Amiar, S., MacRae, J. I., Callahan, D. L., Dubois, D., van Dooren, G. G., Shears, M. J., Cesbron-Delauw, M. F., Marechal, E., McConville, M. J., McFadden, G. I., Yamaryo-Botte, Y. and Botte, C. Y. (2016). Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase. PLoS Pathog 12(8): e1005765.
  2. Lopez, J., Bittame, A., Massera, C., Vasseur, V., Effantin, G., Valat, A., Buaillon, C., Allart, S., Fox, B. A., Rommereim, L. M., Bzik, D. J., Schoehn, G., Weissenhorn, W., Dubremetz, J. F., Gagnon, J., Mercier, C., Cesbron-Delauw, M. F. and Blanchard, N. (2015). Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen. Cell Rep 13(10): 2273-2286.
  3. Bittame, A., Effantin, G., Petre, G., Ruffiot, P., Travier, L., Schoehn, G., Weissenhorn, W., Cesbron-Delauw, M. F., Gagnon, J. and Mercier, C. (2015). Toxoplasma gondii: biochemical and biophysical characterization of recombinant soluble dense granule proteins GRA2 and GRA6. Biochem Biophys Res Commun 459(1): 107-112.
  4. Mercier, C. and Cesbron-Delauw, M. F. (2015). Toxoplasma secretory granules: one population or more? Trends Parasitol 31(2): 60-71.
  5. Saidani, N., Botte, C. Y., Deligny, M., Bonneau, A. L., Reader, J., Lasselin, R., Merer, G., Niepceron, A., Brossier, F., Cintrat, J. C., Rousseau, B., Birkholtz, L. M., Cesbron-Delauw, M. F., Dubremetz, J. F., Mercier, C., Vial, H., Lopez, R. and Marechal, E. (2014). Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs. Antimicrob Agents Chemother 58(5): 2586-2597.
  6. Witola, W. H., Liu, S. R., Montpetit, A., Welti, R., Hypolite, M., Roth, M., Zhou, Y., Mui, E., Cesbron-Delauw, M. F., Fournie, G. J., Cavailles, P., Bisanz, C., Boyer, K., Withers, S., Noble, A. G., Swisher, C. N., Heydemann, P. T., Rabiah, P., Muench, S. P. and McLeod, R. (2014). ALOX12 in human toxoplasmosis. Infect Immun 82(7): 2670-2679.
  7. Cavailles, P., Flori, P., Papapietro, O., Bisanz, C., Lagrange, D., Pilloux, L., Massera, C., Cristinelli, S., Jublot, D., Bastien, O., Loeuillet, C., Aldebert, D., Touquet, B., Fournie, G. J. and Cesbron-Delauw, M. F. (2014). A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage. PLoS Pathog 10(4): e1004005.
  8. Azzouz, N., Kamena, F., Laurino, P., Kikkeri, R., Mercier, C., Cesbron-Delauw, M. F., Dubremetz, J. F., De Cola, L. and Seeberger, P. H. (2013). Toxoplasma gondii secretory proteins bind to sulfated heparin structures. Glycobiology 23(1): 106-120.
  9. Camara, D., Bisanz, C., Barette, C., Van Daele, J., Human, E., Barnard, B., Van der Straeten, D., Stove, C. P., Lambert, W. E., Douce, R., Marechal, E., Birkholtz, L. M., Cesbron-Delauw, M. F., Dumas, R. and Rebeille, F. (2012). Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by natural product rubreserine. J Biol Chem 287(26): 22367-22376.
  10. Hester, J., Mullins, J., Sa, Q., Payne, L., Mercier, C., Cesbron-Delauw, M. F. and Suzuki, Y. (2012). Toxoplasma gondii antigens recognized by IgG antibodies differ between mice with and without active proliferation of tachyzoites in the brain during the chronic stage of infection. Infect Immun 80(10): 3611-3620.
  11. Persat, F., Mercier, C., Ficheux, D., Colomb, E., Trouillet, S., Bendridi, N., Musset, K., Loeuillet, C., Cesbron-Delauw, M. F. and Vincent, C. (2012). A synthetic peptide derived from the parasite Toxoplasma gondii triggers human dendritic cells' migration. J Leukoc Biol 92(6): 1241-1250.
  12. Witola, W. H., Mui, E., Hargrave, A., Liu, S., Hypolite, M., Montpetit, A., Cavailles, P., Bisanz, C., Cesbron-Delauw, M. F.*, Fournie, G. J.* and McLeod, R.* (2011). NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells. Infect Immun 79(2): 756-766. *Equal contribution
  13. Fox, B. A., Falla, A., Rommereim, L. M., Tomita, T., Gigley, J. P., Mercier, C., Cesbron-Delauw, M. F., Weiss, L. M. and Bzik, D. J. (2011). Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection. Eukaryot Cell 10(9): 1193-1206.
  14. Aldebert, D., Hypolite, M., Cavailles, P., Touquet, B., Flori, P., Loeuillet, C. and Cesbron-Delauw, M. F. (2011). Development of high-throughput methods to quantify cysts of Toxoplasma gondii. Cytometry A 79(11): 952-958.
  15. Muniz-Hernandez, S., Carmen, M. G., Mondragon, M., Mercier, C., Cesbron, M. F., Mondragon-Gonzalez, S. L., Gonzalez, S. and Mondragon, R. (2011). Contribution of the residual body in the spatial organization of Toxoplasma gondii tachyzoites within the parasitophorous vacuole. J Biomed Biotechnol 2011: 473983.
  16. Gendrin, C., Bittame, A., Mercier, C. and Cesbron-Delauw, M. F. (2010). Post-translational membrane sorting of the Toxoplasma gondii GRA6 protein into the parasite-containing vacuole is driven by its N-terminal domain. Int J Parasitol 40(11): 1325-1334.
  17. Loeuillet, C., Boelle, P. Y., Lemaire-Vieille, C., Baldazza, M., Naquet, P., Chambon, P., Cesbron-Delauw, M. F., Valleron, A. J., Gagnon, J. and Cesbron, J. Y. (2010). Sex effect in mouse and human prion disease. J Infect Dis 202(4): 648-654.
  18. Loeuillet, C., Lemaire-Vieille, C., Naquet, P., Cesbron-Delauw, M. F., Gagnon, J. and Cesbron, J. Y. (2010). Prion replication in the hematopoeitic compartment is not required for neuroinvasion in scrapie mouse model. PLoS One 10 : 3166.
  19. Botte, C., Saidani, N., Mondragon, R., Mondragon, M., Isaac, G., Mui, E., McLeod, R., Dubremetz, J. F., Vial, H., Welti, R., Cesbron-Delauw, M. F., Mercier, C.* and Marechal, E.* (2008). Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii. J Lipid Res 49(4): 746-762. * Equal contribution
  20. Braun, L., Travier, L., Kieffer, S., Musset, K., Garin, J., Mercier, C. and Cesbron-Delauw, M. F. (2008). Purification of Toxoplasma dense granule proteins reveals that they are in complexes throughout the secretory pathway.Mol Biochem Parasitol 157: 13–21.
  21. Golkar, M., Azadmanesh, K., Khalili, G., Abdel-Latif, M.S., Sima, B. K., Babaie, J., Mercier, C., Brenier-Pinchart, M. P., Fricker-Hidalgo, H. Pelloux, H. and Cesbron-Delauw, M. F. (2008). Serodiagnosis of recently acquired Toxoplasma gondii infection in pregnant women using enzyme-linked immunosorbent assays with a recombinant dense granule GRA6 protein. Diagn Microbiol Infect Dis. 61:31-39.
  22. Travier, L., Mondragon, R., Dubremetz, J. F., Musset, K., Mondragon, M., Gonzalez, S., Cesbron-Delauw, M. F. and Mercier, C. (2008). Functional domains of the Toxoplasma GRA2 protein in the formation of the membranous nanotubular network of the parasitophorous vacuole. Int J Parasitol 38(7): 757-773.
  23. Cesbron-Delauw, M. F., Gendrin, C., Travier, L., Ruffiot, P. and Mercier, C. (2008). Apicomplexa in mammalian cells: trafficking to the parasitophorous vacuole. Traffic 9(5): 657-664.
  24. Morisset, S., Peyron, F., Lobry, J. R., Garweg, J., Ferrandiz, J., Musset, K., Gomez-Marin, J. E., de la Torre, A., Demar, M., Carme, B., Mercier, C., Garin, J. F. and Cesbron-Delauw, M. F. (2008). Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America. Microbes Infect 10(7): 742-747.
  25. Gendrin, C., Mercier, C., Braun, L., Musset, K., Dubremetz, J. F. and Cesbron-Delauw, M. F. (2008). Toxoplasma gondii uses unusual sorting mechanisms to deliver transmembrane proteins into the host-cell vacuole. Traffic 9(10): 1665-1680.
  26. Aldebert, D., Durand, F., Mercier, C., Brenier-Pinchart, M. P., Cesbron-Delauw, M. F. and Pelloux, H. (2007). Toxoplasma gondii triggers secretion of interleukin-12 but low level of interleukin-10 from the THP-1 human monocytic cell line. Cytokine 37(3): 206-211.
  27. Golkar, M., Shokrgozar, M. A., Rafati, S., Musset, K., Assmar, M., Sadaie, R., Cesbron-Delauw, M. F. and Mercier, C. (2007). Evaluation of protective effect of recombinant dense granule antigens GRA2 and GRA6 formulated in monophosphoryl lipid A (MPL) adjuvant against Toxoplasma chronic infection in mice. Vaccine 25(21): 4301-4311.
  28. Golkar, M., Rafati, S., Abdel-Latif, M. S., Brenier-Pinchart, M. P., Fricker-Hidalgo, H., Sima, B. K., Babaie, J., Pelloux, H., Cesbron-Delauw, M. F. and Mercier, C. (2007). The dense granule protein GRA2, a new marker for the serodiagnosis of acute Toxoplasma infection: comparison of sera collected in both France and Iran from pregnant women. Diagn Microbiol Infect Dis 58(4): 419-426.
  29. Azzouz, N., Shams-Eldin, H., Niehus, S., Debierre-Grockiego, F., Bieker, U., Schmidt, J., Mercier, C., Cesbron-Delauw, M. F., Dubremetz, J. F., Smith, T. K., and Schwarz, R. T. (2006). Toxoplasma gondii grown in human cells uses GalNAc-containing glycosylphosphatidylinositol precursors to anchor surface antigens while the immunogenic Glc-GalNAc-containing precursors remain free at the parasite cell surface. Int J Biochem Cell Biol. 38(11):1914-1925.
  30. Brenier-Pinchart, M. P., Villena, I., Mercier, C., Durand, F., Simon, J., Cesbron-Delauw, M. F. and Pelloux, H. (2006). The Toxoplasma surface protein SAG1 triggers efficient in vitro secretion of chemokine ligand 2 (CCL2) from human fibroblasts. Microbes Infect 8(1): 254-261.
  31. Bisanz, C., Bastien, O., Grando, D., Jouhet, J., Marechal, E. and Cesbron-Delauw, M. F. (2006). Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors. Biochem J 394(Pt 1): 197-205.
  32. Candolfi, E., Cesbron-Delauw, M. F., Darde, M. L., Dubremetz, J. F. and Tomavo, S. (2006). The VIIIth international congress on toxoplasmosis. Microb. Infect 8: 1979-1983.
  33. Cavailles, P.*, Sergent, V.*, Bisanz, C., Papapietro, O., Colacios, C., Mas, M., Subra, J. F., Lagrange, D., Calise, M., Appolinaire, S., Faraut, T., Druet, P., Saoudi, A., Bessieres, M. H., Pipy, B., Cesbron-Delauw, M. F.* and Fournie, G. J.* (2006). The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms. Proc Natl Acad Sci U S A 103(3): 744-749. *Contribution égale des deux co-auteurs.
  34. Estran, C., Brenier-Pinchart, M. P., Pelletier, L., Cesbron-Delauw, M. F. and Pelloux, H. (2006). Toxoplasma gondii in human astrocytes in vitro: interleukin (IL)-12 and IL-10 do not influence cystogenesis. J Parasitol 92(5): 1108-1110.
  35. Prigione, I., Chiesa, S., Taverna, P., Ceccarelli, R., Frulio, R., Morandi, F., Bocca, P., Cesbron-Delauw, M. F. and Pistoia, V. (2006). T cell mediated immune responses to Toxoplasma gondii in pregnant women with primary toxoplasmosis. Microbes Infect 8(2): 552-560.
  36. Peyron, F., Lobry, J. R., Musset, K., Ferrandiz, J., Gomez-Marin, J. E., Petersen, E., Meroni, V., Rausher, B., Mercier, C., Picot, S. and Cesbron-Delauw, M. F. (2006). Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America). Microbes Infect 8(9-10): 2333-2340.
  37. Cavaillès, P., Bisanz, C., Papapietro, O., Colacios, C., Sergent, V., Pipy, B., Saoudi, A., Cesbron-Delauw, M. F. and Fournié, G. J.(2006). Chez le rat, le locus Toxo1 contrôle l’issue de l’infection toxoplasmique selon un mode mendélien. M/S 22:679-680.
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