Education
Ph.D., Department of Health Science and Technology, Aalborg University, Denmark, 2005
Current position
Assistant Professor in Clinical Molecular Endocrinology Laboratory, Department of Endocrinology, University of Odense, Odense, Denmark
Publications
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Wang, L., Fan, J., Lin, Y. S., Guo, Y. S., Gao, B., Shi, Q. Y., Wei, B. Y., Chen, L., Yang, L., Liu, J. and Luo, Z. J. (2015). Glucocorticoids induce autophagy in rat bone marrow mesenchymal stem cells. Mol Med Rep 11(4): 2711-2716.
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Hamam, D., Ali, D., Vishnubalaji, R., Hamam, R., Al-Nbaheen, M., Chen, L., Kassem, M., Aldahmash, A. and Alajez, N. M. (2014). microRNA-320/RUNX2 axis regulates adipocytic differentiation of human mesenchymal (skeletal) stem cells. Cell Death Dis 5: e1499.
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Twine, N. A., Chen, L., Pang, C. N., Wilkins, M. R. and Kassem, M. (2014). Identification of differentiation-stage specific markers that define the ex vivo osteoblastic phenotype. Bone 67: 23-32.
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Chen, L., Holmstrom, K., Qiu, W., Ditzel, N., Shi, K., Hokland, L. and Kassem, M. (2014). MicroRNA-34a inhibits osteoblast differentiation and in vivo bone formation of human stromal stem cells. Stem Cells 32(4): 902-912.
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Kristensen, L. P.*, Chen, L.*, Nielsen, M. O., Qanie, D. W., Kratchmarova, I., Kassem, M. and Andersen, J. S. (2012). Temporal profiling and pulsed SILAC labeling identify novel secreted proteins during ex vivo osteoblast differentiation of human stromal stem cells. Mol Cell Proteomics 11(10): 989-1007. (*Co-first author)
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Taipaleenmaki, H., Harkness, L., Chen, L., Larsen, K. H., Saamanen, A. M., Kassem, M. and Abdallah, B. M. (2012). The crosstalk between transforming growth factor-beta1 and delta like-1 mediates early chondrogenesis during embryonic endochondral ossification. Stem Cells 30(2): 304-313.
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Taipaleenmaki, H., Bjerre Hokland, L., Chen, L., Kauppinen, S. and Kassem, M. (2012). Mechanisms in endocrinology: micro-RNAs: targets for enhancing osteoblast differentiation and bone formation. Eur J Endocrinol 166(3): 359-371.
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Qiu, W., Chen, L. and Kassem, M. (2011). Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells. Biochem Biophys Res Commun 413(1): 98-104.
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Andersen, D. C., Kortesidis, A., Zannettino, A. C., Kratchmarova, I., Chen, L., Jensen, O. N., Teisner, B., Gronthos, S., Jensen, C. H. and Kassem, M. (2011). Development of novel monoclonal antibodies that define differentiation stages of human stromal (mesenchymal) stem cells. Mol Cells 32(2): 133-142.
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Choksi, S.*, Lin, Y.*, Pobezinskaya, Y.*, Chen, L., Park, C., Morgan, M., Li, T., Jitkaew, S., Cao, X., Kim, Y. S., Kim, H. S., Levitt, P., Shih, G., Birre, M., Deng, C. X. and Liu, Z. G. (2011). A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2. Mol Cell 42(5): 597-609. (*Co-first author)
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Chen, L., Qanie, D., Jafari, A., Taipaleenmaki, H., Jensen, C. H., Saamanen, A. M., Sanz, M. L., Laborda, J., Abdallah, B. M. and Kassem, M. (2011). Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway. J Biol Chem 286(37): 32140-32149.
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Zou, L., Zou, X., Chen, L., Li, H., Mygind, T., Kassem, M. and Bunger, C. (2008). Multilineage differentiation of porcine bone marrow stromal cells associated with specific gene expression pattern. J Orthop Res 26(1): 56-64.
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Zou, L., Zou, X., Chen, L., Li, H., Mygind, T., Kassem, M. and Bunger, C. (2008). Effect of hyaluronan on osteogenic differentiation of porcine bone marrow stromal cells in vitro. J Orthop Res 26(5): 713-720.
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Chen, L., Fink, T., Ebbesen, P. and Zachar, V. (2006). Temporal transcriptome of mouse ATDC5 chondroprogenitors differentiating under hypoxic conditions. Exp Cell Res 312(10): 1727-1744.
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Chen, L., Fink, T., Ebbesen, P. and Zachar, V. (2006). Optimized chondrogenesis of ATCD5 cells through sequential regulation of oxygen conditions. Tissue Eng 12(3): 559-567.
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Chen, L., Fink, T., Ebbesen, P. and Zachar, V. (2006). Hypoxic treatment inhibits insulin-induced chondrogenesis of ATDC5 cells despite upregulation of DEC1. Connect Tissue Res 47(3): 119-123.
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Hong, J., Chen, L., Jeppesen, P. B., Nordentoft, I. and Hermansen, K. (2006). Stevioside counteracts the alpha-cell hypersecretion caused by long-term palmitate exposure. Am J Physiol Endocrinol Metab 290(3): E416-422.
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Foster, L. J., Zeemann, P. A., Li, C., Mann, M., Jensen, O. N. and Kassem, M. (2005). Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Stem Cells 23(9): 1367-1377.
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Chen, L., Fink, T., Zhang, X., Ebbesen, P. and Zachar, V. (2005). Temporal analysis of a selected transcriptome during of mouse ATDC5 progenitors. Differentiation 73: 350-63.
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Zou, X., Li, H., Chen, L., Baatrup, A., Bunger, C. and Lind, M. (2004). Stimulation of porcine bone marrow stromal cells by hyaluronan, dexamethasone and rhBMP-2. Biomaterials 25(23): 5375-5385.
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Chen, L., Ma, S., Li, B., Fink, T., Zachar, V., Takahashi, M., Cuttichia, J., Tsui, L. C., Ebbesen, P. and Liu, X. (2003). Transcriptional activation of immediate-early gene ETR101 by human T-cell leukaemia virus type I Tax. J Gen Virol 84(Pt 12): 3203-3214.
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Xiang, B., Yu, G. H., Guo, J., Chen, L., Hu, W., Pei, G. and Ma, L. (2001). Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization. J Biol Chem 276(7): 4709-4716.
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Chen, L., Xu, Q., Liu, X. L., Zhao, J. and Ma, L. (1999). Differential and tissue-specific expression of mitochondrial elongation factor Tu and Ts during development. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 31(1): 37-40. (In Chinese)
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Yang, R., Lu, S. D., Zheng, Z. L., Zhao, J., Zhang, X. N., Chen, L., Pei, G. and Ma, L. (1998). Expression of opioid-receptor-like receptor (ORL1) gene in rat brain. Sheng Li Xue Bao 50(2): 139-144. (In Chinese)