Alla Grishok
  • Department of Biochemistry and Molecular Biophysics, Columbia University, USA
Research focus
  • Biochemistry
Personal information


Ph.D. in Cell Biology, Department of Cell Biology, University of Massachusetts, Worcester, 2001

Current position

Assistant Professor, Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, USA


Original research publications

  1. Kennedy, L. M. and Grishok, A. (2014). Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans. Genetics 197(1): 207-220.
  2. Cecere, G., Hoersch, S., O'Keeffe, S., Sachidanandam, R. and Grishok, A. (2014). Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape. Nat Struct Mol Biol 21(4): 358-365.
  3. Kennedy, L. M., Pham, S. C. and Grishok, A. (2013). Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1. Cell Rep 4(5): 996-1009.
  4. Cecere, G., Hoersch, S., Jensen, M. B., Dixit, S. and Grishok, A. (2013). The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Mol Cell 50(6): 894-907.
  5. Avgousti, D. C., Cecere, G. and Grishok, A. (2013). The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans. Mol Cell Biol 33(5): 999-1015.
  6. Avgousti, D. C., Palani, S., Sherman, Y. and Grishok, A. (2012). CSR-1 RNAi pathway positively regulates histone expression in C. elegans. EMBO J 31(19): 3821-3832.
  7. Cecere, G., Zheng, G. X., Mansisidor, A. R., Klymko, K. E. and Grishok, A. (2012). Promoters recognized by forkhead proteins exist for individual 21U-RNAs. Mol Cell 47(5): 734-745.
  8. Mansisidor, A. R.*, Cecere, G.*, Hoersch, S., Jensen, M. B., Kawli, T., Kennedy, L. M., Chavez, V., Tan, M. W., Lieb, J. D. and Grishok, A. (2011). A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans. PLoS Genet 7(9): e1002299. (*Equal contribution)
  9. Grishok, A., Hoersch, S. and Sharp, P. A. (2008). RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans. Proc Natl Acad Sci U S A 105(51): 20386-20391.
  10. Grishok, A. and Sharp, P. A. (2005). Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proc Natl Acad Sci U S A 102(48): 17360-17365.
  11. Grishok, A., Sinskey, J. L. and Sharp, P. A. (2005). Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes Dev 19(6): 683-696.
  12. Grishok, A.*, Pasquinelli, A. E.*, Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D. L., Fire, A., Ruvkun, G. and Mello, C. C. (2001). Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106(1): 23-34. (*Equal contribution)
  13. Grishok, A., Tabara, H. and Mello, C. C. (2000). Genetic requirements for inheritance of RNAi in C. elegans. Science 287(5462): 2494-2497.
  14. Tabara, H., Sarkissian, M., Kelly, W. G., Fleenor, J., Grishok, A., Timmons, L., Fire, A. and Mello, C. C. (1999). The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell 99(2): 123-132.
  15. Neitz, M., Neitz, J. and Grishok, A. (1995). Polymorphism in the number of genes encoding long-wavelength-sensitive cone pigments among males with normal color vision. Vision Res 35(17): 2395-2407.

Reviews and book chapters

  1. Cecere, G. and Grishok, A. (2014). A nuclear perspective on RNAi pathways in metazoans. Biochim Biophys Acta 1839(3): 223-233.
  2. Grishok, A. (2013). Biology and mechanisms of short RNAs in Caenorhabditis elegans. Adv Genet 83: 1-69.
  3. Grishok, A. (2012). Endogenous RNAi and adaptation to environment in C. elegans. Worm 1(2): 129-133.
  4.  Grishok, A. (2005). RNAi mechanisms in Caenorhabditis elegans. FEBS Lett 579(26): 5932-5939.
  5. Petersen, C. P., Doench, J. G., Grishok, A. and Sharp, P. A. (2005). The biology of short RNAs. In: Gesteland, R .F., Cech, T. A. and Atkins, J. F. (eds). The RNA World, 3rd edition. Cold Spring Harbor Laboratory Press, pp. 535-565.
  6. Grishok, A. (2005). RNAi beginnings. Overview of the pathway in C. elegans. In: Appasani, K. (ed). RNA Interference Technology. Cambridge University Press, pp. 17-28.
  7. Grishok, A. and Mello, C. C. (2002). RNAi (Nematodes: Caenorhabditis elegans). Adv Genet 46: 339-360.
  8. Grishok, A. (1995). Extracellular nucleic acids as possible messengers in regulatory information transfer from immune system to non-lymphoid tissues. Med Hypotheses 44(6): 435-438.
  9. Grishok, A. A. (1993). Extracellular nucleic acids as possible messengers of immune system morphogenetic function. Hypothesis about the exchange of regulatory molecules among the cells in an organism. Biopolymers and Cell, 9(6): 5-12. (In Russian)
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