Maria G. Masucci
  • Department of Cell and Molecular Biology, Karolinska Institutet, Sweden
Research focus
  • Cancer biology
Personal information


Ph.D. in Tumor Biology, Department of Tumor Biology, Karolinska Institute, 1985

Current position

Professor of Virology, Karolinska Institute, Stockholm, Sweden

Publications (since 2005)

  1. Coppotelli, G., Mughal, N., Callegari, S., Sompallae, R., Caja, L., Luijsterburg, M. S., Dantuma, N. P., Moustakas, A. and Masucci, M. G. (2013). The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins. Nucleic Acids Res 41(5): 2950-2962.
  2. Kamranvar, S. A., Chen, X. and Masucci, M. G. (2013). Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus. Oncogene 32(49): 5522-5530.
  3. Gastaldello, S., Chen, X., Callegari, S. and Masucci, M. G. (2013). Caspase-1 promotes Epstein-Barr virus replication by targeting the large tegument protein deneddylase to the nucleus of productively infected cells. PLoS Pathog 9(10): e1003664.
  4. Gastaldello, S., Callegari, S., Coppotelli, G., Hildebrand, S., Song, M. and Masucci, M. G. (2012). Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1. J Mol Cell Biol 4(4): 242-251.
  5. Frisan, T., Coppotelli, G., Dryselius, R. and Masucci, M. G. (2012). Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth. FASEB J 26(12): 5060-5070.
  6. Kamranvar, S. A. and Masucci, M. G. (2011). The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress. Leukemia 25(6): 1017-1025.
  7. Gastaldello, S., Hildebrand, S., Faridani, O., Callegari, S., Palmkvist, M., Di Guglielmo, C. and Masucci, M. G. (2010). A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. Nat Cell Biol 12(4): 351-361.
  8. Rolen, U., Freda, E., Xie, J., Pfirrmann, T., Frisan, T. and Masucci, M. G. (2009). The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation. J Cell Mol Med 13(8B): 1666-1678.
  9. Gruhne, B., Sompallae, R., Marescotti, D., Kamranvar, S. A., Gastaldello, S. and Masucci, M. G. (2009). The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species. Proc Natl Acad Sci U S A 106(7): 2313-2318.
  10. Gruhne, B., Sompallae, R. and Masucci, M. G. (2009). Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints. Oncogene 28(45): 3997-4008.
  11. Sompallae, R., Gastaldello, S., Hildebrand, S., Zinin, N., Hassink, G., Lindsten, K., Haas, J., Persson, B. and Masucci, M. G. (2008). Epstein-barr virus encodes three bona fide ubiquitin-specific proteases. J Virol 82(21): 10477-10486.
  12. Kamranvar, S. A., Gruhne, B., Szeles, A. and Masucci, M. G. (2007). Epstein-Barr virus promotes genomic instability in Burkitt's lymphoma. Oncogene 26(35): 5115-5123.
  13. Rolen, U., Kobzeva, V., Gasparjan, N., Ovaa, H., Winberg, G., Kisseljov, F. and Masucci, M. G. (2006). Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines. Mol Carcinog 45(4): 260-269.
  14. Heessen, S., Masucci, M. G. and Dantuma, N. P. (2005). The UBA2 domain functions as an intrinsic stabilization signal that protects Rad23 from proteasomal degradation. Mol Cell 18(2): 225-235.
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