Education
Ph.D. in Biochemistry, University of Glasgow, 1999
Current position
Lecturer in Biochemistry, School of Biological Sciences, Queen’s University Belfast, UK
Publications
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Paul, S., Alegre, K. O., Holdsworth, S. R., Rice, M., Brown, J. A., McVeigh, P., Kelly, S. M. and Law, C. J. (2014). A single-component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress. Mol Microbiol 92(4): 872-884.
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Alegre, K. O., Paul, S. and Law, C. J. (2014). Multidrug transporter proteins of the major facilitator superfamily: not only for drug efflux. In: Nisnevitch, M. (ed). Prokaryotes: Physiology, Biochemistry and Cell Behavior. Nova Publishers.
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Holdsworth, S. R. and Law, C. J. (2013). Multidrug resistance protein MdtM adds to the repertoire of antiporters involved in alkaline pH homeostasis in Escherichia coli. BMC Microbiol 13: 113.
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Holdsworth, S. R. and Law, C. J. (2013). The major facilitator superfamily transporter MdtM contributes to the intrinsic resistance of Escherichia coli to quaternary ammonium compounds. J Antimicrob Chemother 68(4): 831-839.
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Wilkinson, R., Law, C. J., Hoey, E. M., Fairweather, I., Brennan, G. P. and Trudgett, A. (2012). An amino acid substitution in Fasciola hepatica P-glycoprotein from triclabendazole-resistant and triclabendazole-susceptible populations. Mol Biochem Parasitol 186(1): 69-72.
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Holdsworth, S. R. and Law, C. J. (2012). Functional and biochemical characterisation of the Escherichia coli major facilitator superfamily multidrug transporter MdtM. Biochimie 94(6): 1334-1346.
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Law, C. J., Enkavi, G., Wang, D. N. and Tajkhorshid, E. (2009). Structural basis of substrate selectivity in the glycerol-3-phosphate: phosphate antiporter GlpT. Biophys J 97(5): 1346-1353.
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Zhou, Z., Zhen, J., Karpowich, N. K., Law, C. J., Reith, M. E. and Wang, D. N. (2009). Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol 16(6): 652-657.
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Law, C. J., Maloney, P. C. and Wang, D. N. (2008). Ins and outs of major facilitator superfamily antiporters. Annu Rev Microbiol 62: 289-305.
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Law, C. J., Almqvist, J., Bernstein, A., Goetz, R. M., Huang, Y., Soudant, C., Laaksonen, A., Hovmöller, S. and Wang, D.-N. (2008). Salt-bridge dynamics control substrate-induced conformational change in the membrane transporter GlpT. J Mol Biol 378(4): 828-839.
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Law, C. J., Yang, Q., Soudant, C., Maloney, P. C. and Wang, D. N. (2007). Kinetic evidence is consistent with the rocker-switch mechanism of membrane transport by GlpT. Biochemistry 46(43): 12190-12197.
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Law, C. J. and Cogdell, R. J. (2007). The light-harvesting system of purple anoxygenic photosynthetic bacteria. In: Renger, G. (ed). Primary Processes of Photosynthesis:Principles and Apparatus. RSC Publishing, Part 1, pp 205-259.
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Zhou, Z., Zhen, J., Karpowich, N. K., Goetz, R. M., Law, C. J., Reith, M. E. and Wang, D. N. (2007). LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science 317(5843): 1390-1393.
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Codgell, R. J., Southall, J., Gardiner, A. T., Law, C. J., Gall, A., Roszak, A. W. and Isaacs, N. W. (2006). How purple photosynthetic bacteria harvest solar energy. Comptes Rendus Chimie 9(2): 201-206.
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Law, C. J., Gardiner, A. T., Southall, J., Roszak, A. W., Howard, T. D. and Isaacs, N. W. (2005). How purple bacteria harvest light energy. In: Andrews, D. (ed). Energy Harvesting Materials. World Scientific Publishing Co, pp 65-95.
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Cogdell, R. J., Gardiner, A. T., Roszak, A. W., Law, C. J., Southall, J. and Isaacs, N. W. (2004). Rings, ellipses and horseshoes: how purple bacteria harvest solar energy. Photosynth Res 81(3): 207-214.
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Law, C. J., Roszak, A. W., Southall, J., Gardiner, A. T., Isaacs, N. W. and Cogdell, R. J. (2004). The structure and function of bacterial light-harvesting complexes. Mol Membr Biol 21(3): 183-191.
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Parkes-Loach, P. S., Majeed, A. P., Law, C. J. and Loach, P. A. (2004). Interactions stabilizing the structure of the core light-harvesting complex (LH1) of photosynthetic bacteria and its subunit (B820). Biochemistry 43(22): 7003-7016.
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Roszak, A. W., Howard, T. D., Southall, J., Gardiner, A. T., Law, C. J., Isaacs, N. W. and Cogdell, R. J. (2003). Crystal structure of the RC-LH1 core complex from Rhodopseudomonas palustris. Science 302(5652): 1969-1972.
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Law, C. J., Penfold, C. N., Walker, D. C., Moore, G. R., James, R. and Kleanthous, C. (2003). OmpF enhances the ability of BtuB to protect susceptible Escherichia coli cells from colicin E9 cytotoxicity. FEBS Lett 545(2-3): 127-132.
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Law, C. J., Chen, J., Parkes-Loach, P. S. and Loach, P. A. (2003). Interaction of bacteriochlorophyll with the LH1 and PufX polypeptides of photosynthetic bacteria: use of chemically synthesized analogs and covalently attached fluorescent probes. Photosynth Res 75(3): 193-210.
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Parkes-Loach, P. S., Law, C. J., Recchia, P. A., Kehoe, J., Nehrlich, S., Chen, J. and Loach, P. A. (2001). Role of the core region of the PufX protein in inhibition of reconstitution of the core light-harvesting complexes of Rhodobacter sphaeroides and Rhodobacter capsulatus. Biochemistry 40(19): 5593-5601.
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Trissl, H. W., Law, C. J. and Cogdell, R. J. (1999). Uphill energy transfer in LH2-containing purple bacteria at room temperature. Biochim Biophys Acta 1412(2): 149-172.
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Trissl, H. W., Law, C. J. and Cogdell, R. J. (1998). In: Garab, G. and Pusztai, J. (eds). Proceedings of the XIth International Congress on Photosynthesis. Kluwer Academic Publishers, Vol. 1: pp 65-68.
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Law, C. J. and Cogdell, R. J. (1998). The effect of chemical oxidation on the fluorescence of the LH1 (B880) complex from the purple bacterium Rhodobium marinum. FEBS Lett 432(1-2): 27-30.
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Cogdell, R. J., Fyfe, P., Fraser, N., Law, C., Howard, T., McLuskey, K., Prince, S., Freer, A. and Isaacs, N. (1998). Photosynthetic Light Harvesting. In: Caddick, M. X et al. (eds). Microbial responses to light and time. Cambridge University Press, pp 143-158.
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Law, C. J., Prince, S. M. and Cogdell, R. J. (1998). Crystallising the LH1-RC "core" complex of purple bacteria. Biochem Soc Trans 26(2): S160.
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Alden, R., Johnson, E., Nagarajan, V., Parson, W., Law, C. and Cogdell, R. (1997). Calculations of spectroscopic properties of the LH2 bacteriochlorophyll-protein antenna complex from Rhodopseudomonas acidophila. The Journal of Physical Chemistry B 101(23): 4667-4680.
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Law, C. J., Cogdell, R. J. and Trissl, H.-W. (1997). Antenna organisation in the purple bacterium Rhodopseudomonas acidophila studied by fluorescence induction. Photosynth Res 52(2): 157-165.
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Law, C. J. and Price, N. C. (1996). The accessibility of proteins in protein-SDS complexes. Biochem Soc Trans 24(2): 323S.