Education

Ph. D. in Biology, József Attila University, Szeged, 1997

Current position

Group Leader, The Institute of Genetics, Szeged Biological Research Center of The Hungarian Academy of Sciences

Publications

1. Daraba, A., Gali, V. K., Halmai, M., Haracska, L. and Unk, I. (2014). Def1 promotes the degradation of Pol3 for polymerase exchange to occur during DNA-damage--induced mutagenesis in Saccharomyces cerevisiae. PLoS Biol 12(1): e1001771.
   
2. Unk, I., Hajdu, I., Blastyak, A. and Haracska, L. (2010). Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance. DNA Repair (Amst) 9(3): 257-267.
   
3. Blastyak, A., Hajdu, I., Unk, I. and Haracska, L. (2010). Role of double-stranded DNA translocase activity of human HLTF in replication of damaged DNA. Mol Cell Biol 30(3): 684-693.
   
4. Burkovics, P., Hajdu, I., Szukacsov, V., Unk, I. and Haracska, L. (2009). Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage. Nucleic Acids Res 37(13): 4247-4255.
   
5. Acharya, N., Yoon, J. H., Gali, H., Unk, I., Haracska, L., Johnson, R. E., Hurwitz, J., Prakash, L. and Prakash, S. (2008). Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis. Proc Natl Acad Sci U S A 105(46): 17724-17729.
   
6. Unk, I., Hajdu, I., Fatyol, K., Hurwitz, J., Yoon, J. H., Prakash, L., Prakash, S. and Haracska, L. (2008). Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination. Proc Natl Acad Sci U S A 105(10): 3768-3773.
   
7. Blastyak, A., Pinter, L., Unk, I., Prakash, L., Prakash, S. and Haracska, L. (2007). Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression. Mol Cell 28(1): 167-175.
   
8. Unk, I., Hajdu, I., Fatyol, K., Szakal, B., Blastyak, A., Bermudez, V., Hurwitz, J., Prakash, L., Prakash, S. and Haracska, L. (2006). Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. Proc Natl Acad Sci U S A 103(48): 18107-18112.
   
9. Gangavarapu, V., Haracska, L., Unk, I., Johnson, R. E., Prakash, S. and Prakash, L. (2006). Mms2-Ubc13-dependent and -independent roles of Rad5 ubiquitin ligase in postreplication repair and translesion DNA synthesis in Saccharomyces cerevisiae. Mol Cell Biol 26(20): 7783-7790.
   
10. Burkovics, P., Szukacsov, V., Unk, I. and Haracska, L. (2006). Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs. Nucleic Acids Res 34(9): 2508-2515.
    
11. Haracska, L., Unk, I., Prakash, L. and Prakash, S. (2006). Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis. Proc Natl Acad Sci U S A 103(17): 6477-6482.
    
12. Acharya, N., Haracska, L., Johnson, R. E., Unk, I., Prakash, S. and Prakash, L. (2005). Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domain. Molecular and Cellular Biology 25(21): 9734-9740.
    
13. Haracska, L., Acharya, N., Unk, I., Johnson, R. E., Hurwitz, J., Prakash, L. and Prakash, S. (2005). A single domain in human DNA polymerase iota mediates interaction with PCNA: implications for translesion DNA synthesis. Mol Cell Biol 25(3): 1183-1190.
    
14. Unk, I., Haracska, L., Gomes, X. V., Burgers, P. M., Prakash, L. and Prakash, S. (2002). Stimulation of 3'-->5' exonuclease and 3'-phosphodiesterase activities of yeast apn2 by proliferating cell nuclear antigen. Mol Cell Biol 22(18): 6480-6486.
    
15. Haracska, L., Unk, I., Johnson, R. E., Phillips, B. B., Hurwitz, J., Prakash, L. and Prakash, S. (2002). Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. Mol Cell Biol 22(3): 784-791.
    
16. Haracska, L., Johnson, R. E., Unk, I., Phillips, B. B., Hurwitz, J., Prakash, L. and Prakash, S. (2001). Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA. Proc Natl Acad Sci U S A 98(25): 14256-14261.
    
17. Haracska, L., Johnson, R. E., Unk, I., Phillips, B., Hurwitz, J., Prakash, L. and Prakash, S. (2001). Physical and functional interactions of human DNA polymerase eta with PCNA. Mol Cell Biol 21(21): 7199-7206.
    
18. Haracska, L., Kondratick, C. M., Unk, I., Prakash, S. and Prakash, L. (2001). Interaction with PCNA is essential for yeast DNA polymerase eta function. Mol Cell 8(2): 407-415.
    
19. Haracska, L., Unk, I., Johnson, R. E., Johansson, E., Burgers, P. M., Prakash, S. and Prakash, L. (2001). Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites. Genes Dev 15(8): 945-954.
    
20. Unk, I., Haracska, L., Prakash, S. and Prakash, L. (2001). 3'-phosphodiesterase and 3'-->5' exonuclease activities of yeast Apn2 protein and requirement of these activities for repair of oxidative DNA damage. Mol Cell Biol 21(5): 1656-1661.
    
21. Unk, I., Haracska, L., Johnson, R. E., Prakash, S. and Prakash, L. (2000). Apurinic endonuclease activity of yeast Apn2 protein. J Biol Chem 275(29): 22427-22434.
    
22. Unk, I., Kiss-Toth, E. and Boros, I. (1994). Transcription factor AP-4 participates in activation of bovine leukemia virus long terminal repeat by p34 Tax. Nucleic Acids Res 22(23): 4872-4875.
    
23. Kiss-Toth, E. and Unk, I. (1994). A downstream regulatory element activates the bovine leukemia virus promoter. Biochem Biophys Res Commun 202(3): 1553-1561.
    
24. Kiss-Toth, E., Paca-uccaralertkun, S., Unk, I. and Boros, I. (1993). Member of the CREB/ATF protein family, but not CREB alpha plays an active role in BLV tax trans activation in vivo. Nucleic Acids Res 21(16): 3677-3682.