Education
Ph.D., Department of Microbiology, New York University, NY, 1970
Current position
Professor and Head, Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, USA
Publications (since 2009)
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Schuch, R., Lee, H. M., Schneider, B. C., Sauve, K. L., Law, C., Khan, B. K., Rotolo, J. A., Horiuchi, Y., Couto, D. E., Raz, A., Fischetti, V. A., Huang, D. B., Nowinski, R. C. and Wittekind, M. (2014). Combination therapy with lysin CF-301 and antibiotic is superior to antibiotic alone for treating methicillin-resistant Staphylococcus aureus-induced murine bacteremia. J Infect Dis 209(9): 1469-1478.
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Xu, Y., Brenning, B., Clifford, A., Vollmer, D., Bearss, J., Jones, C., McCarthy, V., Aavula, B., Warner, S., Bearss, D. J., McCullar, M. V., Schuch, R., Pelzek, A., Stebbins, C. E., Goldberg, A. R., Fischetti, V. A. and Vankayalapati, H. (2014). Discovery of Novel Inhibitors of 2-Epimerase as Potent Antibacterial Agents with Potent Gram-Positive Activity. ACS Med Chem Lett. 12;4(12):1142-1147.
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Lood, R., Raz, A., Molina, H., Euler, C. W. and Fischetti, V. A. (2014). A highly active and negatively charged Streptococcus pyogenes lysin with a rare D-alanyl-L-alanine endopeptidase activity protects mice against streptococcal bacteremia. Antimicrob Agents Chemother 58(6): 3073-3084.
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Utter, B., Deutsch, D. R., Schuch, R., Winer, B. Y., Verratti, K., Bishop-Lilly, K., Sozhamannan, S. and Fischetti, V. A. (2014). Beyond the chromosome: the prevalence of unique extra-chromosomal bacteriophages with integrated virulence genes in pathogenic Staphylococcus aureus. PLoS One 9(6): e100502.
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Schuch, R., Pelzek, A. J., Fazzini, M. M., Nelson, D. C. and Fischetti, V. A. (2014). Complete Genome Sequence of Bacillus cereus Sensu Lato Bacteriophage Bcp1. Genome Announc 2(3).
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Gilmer, D. B., Schmitz, J. E., Euler, C. W. and Fischetti, V. A. (2013). Novel bacteriophage lysin with broad lytic activity protects against mixed infection by Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy 57(6): 2743-2750.
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Schuch, R., Pelzek, A. J., Raz, A., Euler, C. W., Ryan, P. A., Winer, B. Y., Farnsworth, A., Bhaskaran, S. S., Stebbins, C. E., Xu, Y., Clifford, A., Bearss, D. J., Vankayalapati, H., Goldberg, A. R. and Fischetti, V. A. (2013). Use of a bacteriophage lysin to identify a novel target for antimicrobial development. PLoS One 8(4): e60754.
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Dale, J. B., Fischetti, V. A., Carapetis, J. R., Steer, A. C., Sow, S., Kumar, R., Mayosi, B. M., Rubin, F. A., Mulholland, K., Hombach, J. M., Schodel, F. and Henao-Restrepo, A. M. (2013). Group A streptococcal vaccines: paving a path for accelerated development. Vaccine 31 Suppl 2: B216-222.
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Mujtaba, S., Winer, B. Y., Jaganathan, A., Patel, J., Sgobba, M., Schuch, R., Gupta, Y. K., Haider, S., Wang, R. and Fischetti, V. A. (2013). Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-kappaB activation in infected macrophages. J Biol Chem 288(32): 23458-23472.
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Doehn, J. M., Fischer, K., Reppe, K., Gutbier, B., Tschernig, T., Hocke, A. C., Fischetti, V. A., Loffler, J., Suttorp, N., Hippenstiel, S. and Witzenrath, M. (2013). Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia. J Antimicrob Chemother 68(9): 2111-2117.
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Dhingra, N., Suarez-Farinas, M., Fuentes-Duculan, J., Gittler, J. K., Shemer, A., Raz, A., Fischetti, V. A., Krueger, J. G. and Guttman-Yassky, E. (2013). Attenuated neutrophil axis in atopic dermatitis compared to psoriasis reflects TH17 pathway differences between these diseases. J Allergy Clin Immunol 132(2): 498-501 e493.
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Pastagia, M., Schuch, R., Fischetti, V. A. and Huang, D. B. (2013). Lysins: the arrival of pathogen-directed anti-infectives. J Med Microbiol 62(Pt 10): 1506-1516.
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Kan, S., Fornelos, N., Schuch, R. and Fischetti, V. A. (2013). Identification of a ligand on the Wip1 bacteriophage highly specific for a receptor on Bacillus anthracis. J Bacteriol 195(19): 4355-4364.
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Vouillamoz, J., Entenza, J. M., Giddey, M., Fischetti, V. A., Moreillon, P. and Resch, G. (2013). Bactericidal synergism between daptomycin and the phage lysin Cpl-1 in a mouse model of pneumococcal bacteraemia. Int J Antimicrob Agents 42(5): 416-421.
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Rumah, K. R., Linden, J., Fischetti, V. A. and Vartanian, T. (2013). Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease. PLoS One 8(10): e76359.
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Ohkuni, H., Nagamune, H., Ozaki, N., Tabata, A., Todome, Y., Watanabe, Y., Takahashi, H., Ohkura, K., Kourai, H., Ohtsuka, H., Fischetti, V. A. and Zabriskie, J. B. (2012). Characterization of recombinant Streptococcus mitis-derived human platelet aggregation factor. APMIS 120(1): 56-71.
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Raz, A., Talay, S. R. and Fischetti, V. A. (2012). Cellular aspects of the distinct M protein and SfbI anchoring pathways in Streptococcus pyogenes. Mol Microbiol 84(4): 631-647.
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McGowan, S., Buckle, A. M., Mitchell, M. S., Hoopes, J. T., Gallagher, D. T., Heselpoth, R. D., Shen, Y., Reboul, C. F., Law, R. H., Fischetti, V. A., Whisstock, J. C. and Nelson, D. C. (2012). X-ray crystal structure of the streptococcal specific phage lysin PlyC. Proc Natl Acad Sci U S A 109(31): 12752-12757.
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Aksyuk, A. A., Bowman, V. D., Kaufmann, B., Fields, C., Klose, T., Holdaway, H. A., Fischetti, V. A. and Rossmann, M. G. (2012). Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry. Proc Natl Acad Sci U S A 109(35): 14001-14006.
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Pastagia, M., Euler, C., Chahales, P., Fuentes-Duculan, J., Krueger, J. G. and Fischetti, V. A. (2011). A novel chimeric lysin shows superiority to mupirocin for skin decolonization of methicillin-resistant and -sensitive Staphylococcus aureus strains. Antimicrob Agents Chemother 55(2): 738-744.
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Schmitz, J. E., Schuch, R. and Fischetti, V. A. (2010). Identifying active phage lysins through functional viral metagenomics. Applied and environmental microbiology 76(21): 7181-7187.
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Schmitz, J. E., Ossiprandi, M. C., Rumah, K. R. and Fischetti, V. A. (2011). Lytic enzyme discovery through multigenomic sequence analysis in Clostridium perfringens. Appl Microbiol Biotechnol 89(6): 1783-1795.
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Resch, G., Moreillon, P. and Fischetti, V. A. (2011). A stable phage lysin (Cpl-1) dimer with increased antipneumococcal activity and decreased plasma clearance. Int J Antimicrob Agents 38(6): 516-521.
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Resch, G., Moreillon, P. and Fischetti, V. A. (2011). PEGylating a bacteriophage endolysin inhibits its bactericidal activity. AMB Express 1: 29.
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Schuch, R., Pelzek, A. J., Kan, S. and Fischetti, V. A. (2010). Prevalence of Bacillus anthracis-like organisms and bacteriophages in the intestinal tract of the earthworm Eisenia fetida. Appl Environ Microbiol 76(7): 2286-2294.
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Daniel, A., Euler, C., Collin, M., Chahales, P., Gorelick, K. J. and Fischetti, V. A. (2010). Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 54(4): 1603-1612.
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Fazzini, M. M., Schuch, R. and Fischetti, V. A. (2010). A novel spore protein, ExsM, regulates formation of the exosporium in Bacillus cereus and Bacillus anthracis and affects spore size and shape. J Bacteriol 192(15): 4012-4021.
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Fischetti, V. A. (2010). Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens. Int J Med Microbiol 300(6): 357-362.
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Witzenrath, M., Schmeck, B., Doehn, J. M., Tschernig, T., Zahlten, J., Loeffler, J. M., Zemlin, M., Muller, H., Gutbier, B., Schutte, H., Hippenstiel, S., Fischetti, V. A., Suttorp, N. and Rosseau, S. (2009). Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia. Crit Care Med 37(2): 642-649.
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Schuch, R. and Fischetti, V. A. (2009). The secret life of the anthrax agent Bacillus anthracis: bacteriophage-mediated ecological adaptations. PLoS One 4(8): e6532.
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Schuch, R., Fischetti, V. A. and Nelson, D. C. (2009). A genetic screen to identify bacteriophage lysins. Methods Mol Biol 502: 307-319.
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Fischetti, V. A. (2010). Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens. Int J Med Microbiol 300(6): 357-362.
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Raz, A. and Fischetti, V. A. (2008). Sortase A localizes to distinct foci on the Streptococcus pyogenes membrane. Proc Natl Acad Sci U S A 105(47): 18549-18554.
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Fischetti, V. A. (2008). Bacteriophage lysins as effective antibacterials. Curr Opin Microbiol 11(5): 393-400.