Education

D.Sc., Université Catholique de Louvain, Belgium, 1989

Current position

Director, NE Technology Pte Ltd (2014 to date)
Director, 2^nd Major in Food Science and Technology Programme (joint programme between NTU and Wageningen University) (2013 to date)
Head, Graduate Education Office, Nanyang Environment and Water Research Institute (2013 to date)
Chairman, Promotion and Tenure Evaluation Committee, School of Chemical and Biomedical Engineering, NTU (2011 to date)
Tenured Full Professor, School of Chemical and Biomedical Engineering, NTU (2011 to date)

Publications

Selected from a total of 146

1. Tang, X. and Chen, W. N.* (2014). Enhanced production of fatty alcohols by engineering the TAGs synthesis pathway in Saccharomyces cerevisiae. Biotechnology and bioengineering.
   
2. Tang, X. and Chen, W. N.* (2014). Investigation of fatty acid accumulation in the engineered Saccharomyces cerevisiae under nitrogen limited culture condition. Bioresour Technol 162: 200-206. (IF 5.0)
   
3. Chen, L., Zhang, J., Lee, J. and Chen, W. N.* (2014). Enhancement of free fatty acid production in Saccharomyces cerevisiae by control of fatty acyl-CoA metabolism. Appl Microbiol Biotechnol 98(15): 6739-6750. (IF 3.8)
   
4. Fe Feng, H., Li, X., Chan, V. and Chen, W. N.* (2014). Proteomics based identification of cell migration related proteins in HBV expressing HepG2 cells. PLoS One 9(4): e95621. (IF 4.4)
   
5. Chen, L., Zhang, J. and Chen, W. N.* (2014). Engineering the Saccharomyces cerevisiae beta-oxidation pathway to increase medium chain fatty acid production as potential biofuel. PLoS One 9(1): e84853. (IF 4.4)
   
6. Mohanty, A., Kathawala, M. H., Zhang, J., Chen, W. N., Loo, J. S., Kjelleberg, S., Yang, L. and Cao, B. (2014). Biogenic tellurium nanorods as a novel antivirulence agent inhibiting pyoverdine production in Pseudomonas aeruginosa. Biotechnol Bioeng 111(5): 858-865. (IF 4.2)
   
7. Tan, Y. L. and Chen, W. N.* (2014). MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma: current status and future prospects. World J Gastroenterol 20(20): 5973-5986. (IF 4.4)
   
8. Tang, X., Feng, H., Zhang, J. and Chen, W. N.* (2013). Comparative Proteomics Analysis of Engineered Saccharomyces cerevisiae with Enhanced Biofuel Precursor Production. PloS One 8(12): e84661. (IF 4.4)
   
9. Shi, J., Feng, H., Lee, J. and Chen, W. N.* (2013). Comparative Proteomics Profile of Lipid-Cumulating Oleaginous Yeast: An iTRAQ-Coupled 2-D LC-MS/MS Analysis. PloS One 8(12): e85532. (Invited review) (IF 2.5)
   
10. Tang, X., Feng, H. and Chen, W. N.* (2013). Metabolic engineering for enhanced fatty acids synthesis in Saccharomyces cerevisiae. Metab Eng 16: 95-102. (IF 8.3)
    
11. Zhao, G., Chen, X., Wang, L., Zhou, S., Feng, H., Chen, W. N.*and Lau, R.* (2013). Ultrasound assisted extraction of carbohydrates from microalgae as feedstock for yeast fermentation. Bioresour Technol 128: 337-344. (IF 5.0)
    
12. Feng, H., Zhang, J., Tan, J. Y., Sadrolodabaee, L. and Chen, W. N*. (2012). Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma: current status and future prospects. Future Virology 7(2): 161-171. (IF 1.2)
    
13. Zhou, Y. and Chen, W. N.* (2011). iTRAQ-coupled 2-D LC-MS/MS analysis of cytoplasmic protein profile in Escherichia coli incubated with apidaecin IB. J Proteomics 75(2): 511-516. (IF 5.1)
    
14. Bai, J., Wang, M. X., Chowbay, B., Ching, C. B. and Chen, W. N.* (2011). Metabolic profiling of HepG2 cells incubated with S(-) and R(+) enantiomers of anti-coagulating drug warfarin. Metabolomics 7(3): 353-362. (IF 4.5)
    
15. Bai, J., Ching, C. B., Chowbay, B. and Chen, W. N.* (2010). Secreted protein profile from HepG2 cells incubated by S(-) and R(+) enantiomers of chiral drug warfarin - An analysis in cell-based system and clinical samples. Proteomics Clin Appl 4(10-11): 808-815. (IF 2.9)
    
16. Niu, D., Zhang, J., Ren, Y., Feng, H. and Chen, W. N.* (2009). HBx genotype D represses GSTP1 expression and increases the oxidative level and apoptosis in HepG2 cells. Mol Oncol 3(1): 67-76. (IF 6.7)
    
17. Xu, J. L., Khor, K. A., Sui, J. J., Zhang, J. H. and Chen, W. N.* (2009). Protein expression profiles in osteoblasts in response to differentially shaped hydroxyapatite nanoparticles. Biomaterials 30(29): 5385-5391. (IF 8.3)
    
18. Tan, T. L., Feng, Z., Lu, Y. W., Chan, V. and Chen, W. N.* (2006). Adhesion contact kinetics of HepG2 cells during Hepatitis B virus replication: Involvement of SH3-binding motif in HBX. Biochim Biophys Acta 1762(8): 755-766. (IF 5.2)
    
19. Ng, L. F., Chan, M., Chan, S.-H., Cheng, P. C.-P., Leung, E. H.-C., Chen, W.-N. and Ren, E.-C. (2005). Host heterogeneous ribonucleoprotein K (hnRNP K) as a potential target to suppress hepatitis B virus replication. PLoS medicine 2(7): e163. (IF 15.3)
    
20. Chen, W. N.*, Oon, C. J. and Toh, I. (2000). Altered antigenicities of hepatitis B virus surface antigen carrying mutations outside the common "a" determinant. Am J Gastroenterol 95(4): 1098-1099. (IF9.2)
    
21. Chen, W., Chen, S., Yap, S. F. and Lim, L. (1996). The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation. J Biol Chem 271(42): 26362-26368. (IF 5.5)
    
22. Chen, W., Lim, H. H. and Lim, L. (1993). The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation. J Biol Chem 268(18): 13280-13285. (IF 5.5)
    
23. Balzi, E., Chen, W., Ulaszewski, S., Capieaux, E. and Goffeau, A. (1987). The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J Biol Chem 262(35): 16871-16879. (IF 5.5)