Education
M.D., Ph.D., Harvard Medical School, Cambridge, Massachusetts, USA
Current position
Endowed Chair, Allergy and Immunology, Cincinnati Children’s Hospital Research Foundation, Cincinnati, Ohio, USA (since 2001)
Director, Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA (since 2001)
Professor of Pediatrics (tenured), Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA (since 2002)
Director, Cincinnati Center for Eosinophilic Disorders, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA (since 2005)
Visiting Full Professor, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel (since 2010)
Publications
Original peer reviewed references (since 2009)
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Sherrill,
J. D., Kiran, K. C., Blanchard, C., Stucke, E. M., Kemme, K. A., Collins, M.
H., Abonia, J. P., Putnam, P. E., Mukkada, V. A., Kaul, A., Kocoshis, S. A.,
Kushner, J. P., Plassard, A. J., Karns, R. A., Dexheimer, P. J., Aronow, B. J.
and Rothenberg, M. E. (2014). Analysis and expansion of
the eosinophilic esophagitis transcriptome by RNA sequencing. Genes
Immun. (Epub ahead of print)
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Wen,
T., Mingler, M. K., Wahl, B., Khorki, M. E., Pabst, O., Zimmermann, N. and
Rothenberg, M. E. (2014). Carbonic
Anhydrase IV Is Expressed on IL-5-Activated Murine Eosinophils. J
Immunol 192(12): 5481-5489.
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Jung,
Y. J and Rothenberg, M. E. Roles and regulation of gastrointestinal eosinophils
in immunity and disease. J Immunol (In
press)
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Butz,
B. K., Wen, T., Gleich, G. J., Furuta, G. T., Spergel, J., King, E., Kramer, R.
E., Collins, M. H., Stucke, E., Mangeot, C., Jackson, W. D., O'Gorman, M.,
Abonia, J. P., Pentiuk, S., Putnam, P. E. and Rothenberg, M. E. (2014). Efficacy, Dose Reduction,
and Resistance to High-Dose Fluticasone in Patients With Eosinophilic
Esophagitis. Gastroenterology. (Epub ahead of print)
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Sherrill,
J. D. and Rothenberg, M. E. (2014). Genetic and epigenetic
underpinnings of eosinophilic esophagitis. Gastroenterol Clin North Am 43(2): 269-280.
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Minar,
P., Haberman, Y., Jurickova, I., Wen, T., Rothenberg, M. E., Kim, M. O., Saeed,
S. A., Baldassano, R. N., Stephens, M., Markowitz, J., Rosh, J., Crandall, W.
V., Heyman, M. B., Mack, D. R., Griffiths, A. M., Baker, S. S., Hyams, J. S.,
Kugathasan, S. and Denson, L. A. (2014). Utility of Neutrophil Fcgamma Receptor
I (CD64) Index as a
Biomarker for Mucosal Inflammation in Pediatric Crohn's Disease. Inflamm
Bowel Dis 20(6): 1037-1048.
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Davis,
B. P. and Rothenberg, M. E. (2014). Eosinophils and cancer. Cancer
Immunol Res 2(1): 1-8.
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Azouz,
N. P., Zur, N., Efergan, A., Ohbayashi, N., Fukuda, M., Amihai, D., Hammel, I.,
Rothenberg, M. E. and Sagi-Eisenberg, R. (2014). Rab5 is a novel
regulator of mast cell secretory granules: impact on size, cargo, and
exocytosis. The Journal of Immunology 192(9): 4043-4053.
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Lyons,
J. J., Sun, G., Stone, K. D., Nelson, C., Wisch, L., O'Brien, M., Jones, N.,
Lindsley, A., Komarow, H. D., Bai, Y., Scott, L. M., Cantave, D., Maric, I.,
Abonia, J. P., Rothenberg, M. E., Schwartz, L. B., Milner, J. D. and Wilson, T.
M. (2014). Mendelian
inheritance of elevated serum tryptase associated with atopy and connective
tissue abnormalities. J Allergy Clin Immunol 133(5): 1471-1474.
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Lim, E. and Rothenberg, M. E. (2014). Demethylation of the human
eotaxin-3 gene promoter leads to the elevated expression of eotaxin-3. J
Immunol 192(1): 466-474.
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Krishnamurthy, P., Sherrill, J. D., Parashette,
K., Goenka, S., Rothenberg, M. E., Gupta, S. and Kaplan, M. H. (2014). Correlation of increased
PARP14 and CCL26 expression in biopsies from children with eosinophilic
esophagitis. J Allergy Clin Immunol 133(2): 577-580.
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Sherrill, J. D., Kc, K., Wu, D., Djukic, Z.,
Caldwell, J. M., Stucke, E. M., Kemme, K. A., Costello, M. S., Mingler, M. K.,
Blanchard, C., Collins, M. H., Abonia, J. P., Putnam, P. E., Dellon, E. S.,
Orlando, R. C., Hogan, S. P. and Rothenberg, M. E. (2014). Desmoglein-1 regulates
esophageal epithelial barrier function and immune responses in eosinophilic
esophagitis. Mucosal Immunol 7(3): 718-729.
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Ben Baruch-Morgenstern, N., Shik, D., Moshkovits,
I., Itan, M., Karo-Atar, D., Bouffi, C., Fulkerson, P. C., Rashkovan, D., Jung,
S., Rothenberg, M. E. and Munitz, A. (2014). Paired immunoglobulin-like
receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil
development. Nat Immunol 15(1): 36-44.
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Greenhawt, M., Aceves, S. S., Spergel, J. M.
and Rothenberg, M. E. (2013). The
Management of Eosinophilic Esophagitis. The Journal of Allergy and
Clinical Immunology: In Practice 1(4): 332-340.
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Henderson, C. J., Ngeow, J., Collins, M. H.,
Martin, L. J., Putnam, P. E., Abonia, J. P., Marsolo, K., Eng, C. and
Rothenberg, M. E. (2013). Increased
prevalence of eosinophilic gastrointestinal disorders (EGID) in pediatric PTEN
hamartoma tumor syndromes (PHTS). Journal
of pediatric gastroenterology and nutrition 58:553-60.
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Davis, B. P. and Rothenberg, M. E. (2013). Antigen presentation by
eosinophils in eosinophilic esophagitis? J Pediatr Gastroenterol Nutr 56(3): 242.
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Henderson, C. J., Collins, M. H., Abonia, J.
P., Putnam, P. E. and Rothenberg, M. E. (2013). Reply: To PMID 22541246. J Allergy Clin Immunol 131(1): 243-244.
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Roufosse, F. E., Kahn, J. E., Gleich, G. J.,
Schwartz, L. B., Singh, A. D., Rosenwasser, L. J., Denburg, J. A., Ring, J.,
Rothenberg, M. E., Sheikh, J., Haig, A. E., Mallett, S. A., Templeton, D. N.,
Ortega, H. G. and Klion, A. D. (2013). Long-term safety of
mepolizumab for the treatment of hypereosinophilic syndromes. J Allergy
Clin Immunol 131(2): 461-467 e461-465.
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Sheikh, S. Z. and Burks, A. W. (2013). Behavioral
Feeding Problems and Parenting Stress in Eosinophilic Gastrointestinal
Disorders in Children. Pediatrics 132(Supplement 1): S24-S24.
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Assa'ad, A. H. and Rothenberg, M. E. (2013). Eosinophilic asthma:
insights into the effects of reducing IL-5 receptor-positive cell levels. J
Allergy Clin Immunol 132(5): 1097-1098.
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Bouffi, C., Rochman, M., Zust, C. B., Stucke,
E. M., Kartashov, A., Fulkerson, P. C., Barski, A. and Rothenberg, M. E.
(2013). IL-33 markedly
activates murine eosinophils by an NF-kappaB-dependent mechanism differentially
dependent upon an IL-4-driven autoinflammatory loop. J Immunol 191(8): 4317-4325.
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Wen, T., Stucke, E. M., Grotjan, T. M., Kemme,
K. A., Abonia, J. P., Putnam, P. E., Franciosi, J. P., Garza, J. M., Kaul, A.,
King, E. C., Collins, M. H., Kushner, J. P. and Rothenberg, M. E. (2013). Molecular diagnosis of
eosinophilic esophagitis by gene expression profiling. Gastroenterology 145(6): 1289-1299.
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Ding, L., Abebe, T., Beyene, J., Wilke, R. A.,
Goldberg, A., Woo, J. G., Martin, L. J., Rothenberg, M. E., Rao, M., Hershey,
G. K., Chakraborty, R. and Mersha, T. B. (2013). Rank-based genome-wide
analysis reveals the association of ryanodine receptor-2 gene variants with
childhood asthma among human populations. Hum Genomics 7: 16.
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Lu, T. X. and Rothenberg, M. E. (2013). Diagnostic, functional, and
therapeutic roles of microRNA in allergic diseases. J Allergy Clin
Immunol 132(1): 3-13; quiz 14.
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Wang, Y. H., Hogan, S. P., Fulkerson, P. C.,
Abonia, J. P. and Rothenberg, M. E. (2013). Expanding the paradigm of
eosinophilic esophagitis: mast cells and IL-9. J Allergy Clin Immunol 131(6): 1583-1585.
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Abonia, J. P., Wen, T., Stucke, E. M., Grotjan,
T., Griffith, M. S., Kemme, K. A., Collins, M. H., Putnam, P. E., Franciosi, J.
P., von Tiehl, K. F., Tinkle, B. T., Marsolo, K. A., Martin, L. J., Ware, S. M.
and Rothenberg, M. E. (2013). High prevalence of eosinophilic
esophagitis in patients with inherited connective tissue disorders. J
Allergy Clin Immunol 132(2): 378-386.
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Davis, B. P. and Rothenberg, M. E. (2013). Emerging concepts of
dietary therapy for pediatric and adult eosinophilic esophagitis. Expert
Rev Clin Immunol 9(4): 285-287.
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Wen, T., Besse, J. A., Mingler, M. K.,
Fulkerson, P. C. and Rothenberg, M. E. (2013). Eosinophil adoptive transfer
system to directly evaluate pulmonary eosinophil trafficking in vivo. Proc Natl Acad Sci U S A 110(15): 6067-6072.
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Lu, T. X., Lim, E. J., Itskovich, S., Besse, J.
A., Plassard, A. J., Mingler, M. K., Rothenberg, J. A., Fulkerson, P. C., Aronow,
B. J. and Rothenberg, M. E. (2013). Targeted ablation of miR-21
decreases murine eosinophil progenitor cell growth. PLoS One 8(3):
e59397.
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Franciosi, J. P., Hommel, K. A., Bendo, C. B.,
King, E. C., Collins, M. H., Eby, M. D., Marsolo, K., Abonia, J. P., von Tiehl,
K. F., Putnam, P. E., Greenler, A. J., Greenberg, A. B., Bryson, R. A., Davis,
C. M., Olive, A. P., Gupta, S. K., Erwin, E. A., Klinnert, M. D., Spergel, J.
M., Denham, J. M., Furuta, G. T., Rothenberg, M. E. and Varni, J. W. (2013). PedsQL eosinophilic
esophagitis module: feasibility, reliability, and validity. J Pediatr
Gastroenterol Nutr 57(1): 57-66.
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Bochner, B. S., Rothenberg, M. E., Boyce, J. A.
and Finkelman, F. (2013). Advances
in mechanisms of allergy and clinical immunology in 2012. J Allergy Clin
Immunol 131(3): 661-667.
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Collison, A., Hatchwell, L., Verrills, N.,
Wark, P. A., de Siqueira, A. P., Tooze, M., Carpenter, H., Don, A. S., Morris,
J. C., Zimmermann, N., Bartlett, N. W., Rothenberg, M. E., Johnston, S. L.,
Foster, P. S. and Mattes, J. (2013). The E3 ubiquitin ligase
midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein
phosphatase 2A activity. Nat Med 19(2): 232-237.
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Fulkerson, P. C. and Rothenberg, M. E. (2013). Targeting eosinophils in
allergy, inflammation and beyond. Nat Rev Drug Discov 12(2):
117-129.
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Lu, T. X., Lim, E. J., Besse, J. A., Itskovich,
S., Plassard, A. J., Fulkerson, P. C., Aronow, B. J. and Rothenberg, M. E.
(2013). MiR-223
deficiency increases eosinophil progenitor proliferation. J Immunol 190(4): 1576-1582.
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Valent, P., Klion, A. D., Rosenwasser, L. J.,
Arock, M., Bochner, B. S., Butterfield, J. H., Gotlib, J., Haferlach, T.,
Hellmann, A., Horny, H. P., Leiferman, K. M., Metzgeroth, G., Matsumoto, K.,
Reiter, A., Roufosse, F., Rothenberg, M. E., Simon, H. U., Sotlar, K.,
Vandenberghe, P., Weller, P. F. and Gleich, G. J. (2012). ICON: Eosinophil Disorders. World Allergy Organ J 5(12): 174-181.
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Winer, K. K., Rothenberg, M. E., Guimond, J.,
Handwerger, S., Boxer, L. A., Grave, G., Devaskar, S. U. and Castle, V. P.
(2012). The Child Health
Research Centers: twenty-one years of promoting the development of pediatrician
scientists from 1990-2011. J Pediatr 161(6): 975-976.
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Franciosi, J. P., Hommel, K. A., Greenberg, A.
B., DeBrosse, C. W., Greenler, A. J., Abonia, J. P., Rothenberg, M. E. and
Varni, J. W. (2012). Development of the Pediatric Quality of Life Inventory Eosinophilic Esophagitis
module items: qualitative methods. BMC Gastroenterol 12: 135.
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Rothenberg, M. E., Aceves, S., Bonis, P. A.,
Collins, M. H., Gonsalves, N., Gupta, S. K., Hirano, I., Liacouras, C. A.,
Putnam, P. E., Spergel, J. M., Straumann, A., Wershil, B. K. and Furuta, G. T.
(2012). Working with the
US Food and Drug Administration: progress and timelines in understanding and
treating patients with eosinophilic esophagitis. J Allergy Clin Immunol 130(3): 617-619.
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Bochner, B. S., Book, W., Busse, W. W.,
Butterfield, J., Furuta, G. T., Gleich, G. J., Klion, A. D., Lee, J. J.,
Leiferman, K. M., Minnicozzi, M., Moqbel, R., Rothenberg, M. E., Schwartz, L.
B., Simon, H. U., Wechsler, M. E. and Weller, P. F. (2012). Workshop report from the
National Institutes of Health Taskforce on the Research Needs of
Eosinophil-Associated Diseases (TREAD). J Allergy Clin Immunol 130(3): 587-596.
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Wechsler, M. E., Fulkerson, P. C., Bochner, B.
S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K.,
Ortega, H., Patel, J., Prussin, C., Renzi, P., Rothenberg, M. E., Roufosse, F.,
Simon, D., Simon, H. U., Wardlaw, A., Weller, P. F. and Klion, A. D. (2012). Novel
targeted therapies for eosinophilic disorders. J Allergy Clin Immunol 130(3): 563-571.
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Butsch Kovacic, M., Biagini Myers, J. M.,
Lindsey, M., Patterson, T., Sauter, S., Ericksen, M. B., Ryan, P., Assa'ad, A.,
Lierl, M., Fischer, T., Kercsmar, C., McDowell, K., Lucky, A. W., Sheth, A. P.,
Hershey, A. D., Ruddy, R. M., Rothenberg, M. E. and Khurana Hershey, G. K.
(2012). The Greater
Cincinnati Pediatric Clinic Repository: A Novel Framework for Childhood Asthma
and Allergy Research. Pediatr Allergy Immunol Pulmonol 25(2):
104-113.
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Henderson, C. J., Abonia, J. P., King, E. C.,
Putnam, P. E., Collins, M. H., Franciosi, J. P. and Rothenberg, M. E. (2012). Comparative dietary therapy
effectiveness in remission of pediatric eosinophilic esophagitis. J
Allergy Clin Immunol 129(6): 1570-1578.
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Lu, T., Lim, E., Wen, T., Plassard, A., Hogan,
S., Martin, L., Aronow, B. and Rothenberg, M. (2012). MiR-375 is
downregulated in epithelial cells after IL-13 stimulation and regulates an
IL-13-induced epithelial transcriptome. Mucosal immunology 5(4):
388-396.
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Hommel, K. A., Franciosi, J. P., Gray, W. N.,
Hente, E. A., Ahrens, A. and Rothenberg, M. E. (2012). Behavioral
functioning and treatment adherence in pediatric eosinophilic gastrointestinal
disorders. Pediatric Allergy and Immunology 23(5): 494-499.
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Lu, T. X., Sherrill, J. D., Wen, T., Plassard,
A. J., Besse, J. A., Abonia, J. P., Franciosi, J. P., Putnam, P. E., Eby, M.,
Martin, L. J., Aronow, B. J. and Rothenberg, M. E. (2012). MicroRNA signature in
patients with eosinophilic esophagitis, reversibility with glucocorticoids, and
assessment as disease biomarkers. J Allergy Clin Immunol 129(4):
1064-1075 e1069.
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Boyce, J. A., Bochner, B., Finkelman, F. D. and
Rothenberg, M. E. (2012). Advances
in mechanisms of asthma, allergy, and immunology in 2011. J Allergy Clin
Immunol 129(2): 335-341.
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Munitz, A., Cole, E. T., Karo-Atar, D.,
Finkelman, F. D. and Rothenberg, M. E. (2012). Resistin-like molecule-alpha
regulates IL-13-induced chemokine production but not allergen-induced airway
responses. Am J Respir Cell Mol Biol 46(5): 703-713.
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Spergel, J. M., Rothenberg, M. E., Collins, M.
H., Furuta, G. T., Markowitz, J. E., Fuchs, G., 3rd, O'Gorman, M. A., Abonia,
J. P., Young, J., Henkel, T., Wilkins, H. J. and Liacouras, C. A. (2012). Reslizumab in children and
adolescents with eosinophilic esophagitis: results of a double-blind,
randomized, placebo-controlled trial. J Allergy Clin Immunol 129(2):
456-463, 463 e451-453.
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Wen, T., Mingler, M. K., Blanchard, C., Wahl,
B., Pabst, O. and Rothenberg, M. E. (2012). The pan-B cell marker CD22
is expressed on gastrointestinal eosinophils and negatively regulates tissue
eosinophilia. J Immunol 188(3): 1075-1082.
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Hommel, K. A., Franciosi, J. P., Hente, E. A.,
Ahrens, A. and Rothenberg, M. E. (2012). Treatment adherence in
pediatric eosinophilic gastrointestinal disorders. J Pediatr Psychol 37(5): 533-542.
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Abonia, J. P. and Rothenberg, M. E. (2012). Eosinophilic esophagitis:
rapidly advancing insights. Annu Rev Med 63: 421-434.
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Munitz, A., Cole, E. T., Karo-Atar, D.,
Finkelman, F. D. and Rothenberg, M. E. (2012). Resistin-Like
Molecule–α Regulates IL-13–Induced Chemokine Production but Not
Allergen-Induced Airway Responses. American journal of respiratory cell
and molecular biology 46(5): 703-713.
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Franciosi, J., Hommel, K., DeBrosse, C.,
Greenberg, A., Greenler, A., Abonia, J., Rothenberg, M. and Varni, J. (2012). Quality
of life in paediatric eosinophilic oesophagitis: what is important to patients? Child: care, health and development 38(4): 477-483.
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Franciosi, J. P., Hommel, K. A., DeBrosse, C.
W., Greenberg, A. B., Greenler, A. J., Abonia, J. P., Rothenberg, M. E. and
Varni, J. W. (2011). Development
of a validated patient-reported symptom metric for pediatric eosinophilic
esophagitis: qualitative methods. BMC Gastroenterol 11: 126.
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Rothenberg, M. E., Wen, T., Shik, D., Cole, E.
T., Mingler, M. M. and Munitz, A. (2011). IL-13 receptor alpha1
differentially regulates aeroallergen-induced lung responses. J Immunol 187(9): 4873-4880.
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Lu, T. X., Hartner, J., Lim, E. J., Fabry, V.,
Mingler, M. K., Cole, E. T., Orkin, S. H., Aronow, B. J. and Rothenberg, M. E.
(2011). MicroRNA-21
limits in vivo immune
response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization,
and the severity of delayed-type hypersensitivity. J Immunol 187(6):
3362-3373.
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DeBrosse, C. W., Franciosi, J. P., King, E. C.,
Butz, B. K., Greenberg, A. B., Collins, M. H., Abonia, J. P., Assa'ad, A.,
Putnam, P. E. and Rothenberg, M. E. (2011). Long-term outcomes in
pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol 128(1): 132-138.
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Lacy, P., Willetts, L., Kim, J. D., Lo, A. N.,
Lam, B., Maclean, E. I., Moqbel, R., Rothenberg, M. E. and Zimmermann, N.
(2011). Agonist
activation of f-actin-mediated eosinophil shape change and mediator release is dependent
on Rac2. Int Arch Allergy Immunol 156(2): 137-147.
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Sherrill, J. D. and Rothenberg, M. E. (2011). Genetic dissection of
eosinophilic esophagitis provides insight into disease pathogenesis and
treatment strategies. J Allergy Clin Immunol 128(1): 23-32; quiz
33-24.
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Waddell, A., Ahrens, R., Steinbrecher, K.,
Donovan, B., Rothenberg, M. E., Munitz, A. and Hogan, S. P. (2011). Colonic eosinophilic
inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+)
inflammatory monocyte/macrophage-derived CCL11. J Immunol 186(10):
5993-6003.
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Liacouras, C. A., Furuta, G. T., Hirano, I., Atkins,
D., Attwood, S. E., Bonis, P. A., Burks, A. W., Chehade, M., Collins, M. H.,
Dellon, E. S., Dohil, R., Falk, G. W., Gonsalves, N., Gupta, S. K., Katzka, D.
A., Lucendo, A. J., Markowitz, J. E., Noel, R. J., Odze, R. D., Putnam, P. E.,
Richter, J. E., Romero, Y., Ruchelli, E., Sampson, H. A., Schoepfer, A.,
Shaheen, N. J., Sicherer, S. H., Spechler, S., Spergel, J. M., Straumann, A.,
Wershil, B. K., Rothenberg, M. E. and Aceves, S. S. (2011). Eosinophilic esophagitis:
updated consensus recommendations for children and adults. J Allergy
Clin Immunol 128(1): 3-20 e26; quiz 21-22.
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Baye, T. M., Butsch Kovacic, M., Biagini Myers,
J. M., Martin, L. J., Lindsey, M., Patterson, T. L., He, H., Ericksen, M. B.,
Gupta, J., Tsoras, A. M., Lindsley, A., Rothenberg, M. E., Wills-Karp, M.,
Eissa, N. T., Borish, L. and Khurana Hershey, G. K. (2011). Differences in candidate
gene association between European ancestry and African American asthmatic
children. PLoS One 6(2): e16522.
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Broide, D. H., Finkelman, F., Bochner, B. S.
and Rothenberg, M. E. (2011). Advances in mechanisms of
asthma, allergy, and immunology in 2010. J Allergy Clin Immunol 127(3): 689-695.
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Lim, E. J., Lu, T. X., Blanchard, C. and
Rothenberg, M. E. (2011). Epigenetic
regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding
protein-mediated histone 3 acetylation. J Biol Chem 286(15):
13193-13204.
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Wu, D., Ahrens, R., Osterfeld, H., Noah, T. K., Groschwitz, K., Foster, P. S., Steinbrecher, K. A., Rothenberg, M. E., Shroyer,
N. F., Matthaei, K. I., Finkelman, F. D. and Hogan, S. P. (2011). Interleukin-13 (IL-13)/IL-13
receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic
fibrosis transmembrane conductance regulator channel-dependent Cl- secretion. J Biol Chem 286(15): 13357-13369.
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Blanchard, C., Stucke, E. M.,
Rodriguez-Jimenez, B., Burwinkel, K., Collins, M. H., Ahrens, A., Alexander, E.
S., Butz, B. K., Jameson, S. C., Kaul, A., Franciosi, J. P., Kushner, J. P.,
Putnam, P. E., Abonia, J. P. and Rothenberg, M. E. (2011). A striking local esophageal
cytokine expression profile in eosinophilic esophagitis. J Allergy Clin
Immunol 127(1): 208-217, 217 e201-207.
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Zhu, H., Perkins, C., Mingler, M. K.,
Finkelman, F. D. and Rothenberg, M. E. (2011). The role of neuropeptide S
and neuropeptide S receptor 1 in regulation of respiratory function in mice. Peptides 32(4): 818-825.
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Miles, M. V., Putnam, P. E., Miles, L., Tang,
P. H., DeGrauw, A. J., Wong, B. L., Horn, P. S., Foote, H. L. and Rothenberg,
M. E. (2011). Acquired
coenzyme Q10 deficiency in children with recurrent food intolerance and
allergies. Mitochondrion 11(1): 127-135.
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Cortina, S., McGraw, K., Dealarcon, A., Ahrens,
A., Rothenberg, M. E. and Drotar, D. (2010). Psychological Functioning of
Children and Adolescents With Eosinophil-Associated Gastrointestinal Disorders. Child Health Care 39(4): 266-278.
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Abonia, J. P., Franciosi, J. P. and Rothenberg,
M. E. (2010). TGFβ1:
Mediator of a feedback loop in eosinophilic esophagitis… or should we really
say mastocytic esophagitis? The Journal of allergy and clinical
immunology 126(6): 1205.
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Sivaprasad, U., Warrier, M. R., Gibson, A. M.,
Chen, W., Tabata, Y., Bass, S. A., Rothenberg, M. E. and Hershey, G. K. K.
(2010). IL-13Rα2
has a protective role in a mouse model of cutaneous inflammation. The
Journal of Immunology 185(11): 6802-6808.
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Rothenberg, M. E. (2010). Innate sensing of nickel. Nat Immunol 11(9): 781-782.
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Simon, H. U., Rothenberg, M. E., Bochner, B.
S., Weller, P. F., Wardlaw, A. J., Wechsler, M. E., Rosenwasser, L. J.,
Roufosse, F., Gleich, G. J. and Klion, A. D. (2010). Refining the definition of
hypereosinophilic syndrome. J Allergy Clin Immunol 126(1): 45-49.
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Sherrill, J. D., Gao, P. S., Stucke, E. M.,
Blanchard, C., Collins, M. H., Putnam, P. E., Franciosi, J. P., Kushner, J. P.,
Abonia, J. P., Assa'ad, A. H., Kovacic, M. B., Biagini Myers, J. M., Bochner,
B. S., He, H., Hershey, G. K., Martin, L. J. and Rothenberg, M. E. (2010). Variants of thymic stromal
lymphopoietin and its receptor associate with eosinophilic esophagitis. J
Allergy Clin Immunol 126(1): 160-165 e163.
-
DeBrosse, C. W., Collins, M. H., Buckmeier
Butz, B. K., Allen, C. L., King, E. C., Assa'ad, A. H., Abonia, J. P., Putnam,
P. E., Rothenberg, M. E. and Franciosi, J. P. (2010). Identification,
epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol 126(1): 112-119.
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Niese, K. A., Chiaramonte, M. G., Ellies, L.
G., Rothenberg, M. E. and Zimmermann, N. (2010). The cationic amino acid
transporter 2 is induced in inflammatory lung models and regulates lung
fibrosis. Respir Res 11: 87.
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Zuo, L., Fulkerson, P. C., Finkelman, F. D.,
Mingler, M., Fischetti, C. A., Blanchard, C. and Rothenberg, M. E. (2010). IL-13 induces esophageal
remodeling and gene expression by an eosinophil-independent, IL-13R alpha
2-inhibited pathway. J Immunol 185(1): 660-669.
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Abonia, J. P., Blanchard, C., Butz, B. B.,
Rainey, H. F., Collins, M. H., Stringer, K., Putnam, P. E. and Rothenberg, M.
E. (2010). Involvement of
mast cells in eosinophilic esophagitis. J Allergy Clin Immunol 126(1): 140-149.
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Rosenwasser, L. J. and Rothenberg, M. E.
(2010). IL-5 pathway
inhibition in the treatment of asthma and Churg-Strauss syndrome. J
Allergy Clin Immunol 125(6): 1245-1246.
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Herbert, D. R., Orekov, T., Roloson, A., Ilies,
M., Perkins, C., O'Brien, W., Cederbaum, S., Christianson, D. W., Zimmermann,
N., Rothenberg, M. E. and Finkelman, F. D. (2010). Arginase I suppresses
IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. J
Immunol 184(11): 6438-6446.
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Rayapudi, M., Mavi, P., Zhu, X., Pandey, A. K.,
Abonia, J. P., Rothenberg, M. E. and Mishra, A. (2010). Indoor insect allergens are
potent inducers of experimental eosinophilic esophagitis in mice. J
Leukoc Biol 88(2): 337-346.
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Munitz, A., Cole, E. T., Beichler, A.,
Groschwitz, K., Ahrens, R., Steinbrecher, K., Willson, T., Han, X., Denson, L.,
Rothenberg, M. E. and Hogan, S. P. (2010). Paired immunoglobulin-like
receptor B (PIR-B) negatively regulates macrophage activation in experimental
colitis. Gastroenterology 139(2): 530-541.
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Simon, D., Wardlaw, A. and Rothenberg, M. E. (2010). Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract. J Allergy Clin Immunol 126(1): 3-13; quiz 14-15.
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Simon, D., Wardlaw, A. and Rothenberg, M. E.
(2010). Organ-specific
eosinophilic disorders of the skin, lung, and gastrointestinal tract. J
Allergy Clin Immunol 126(1): 3-13; quiz 14-15.
Zhu, X., Wang, M., Mavi, P., Rayapudi, M.,
Pandey, A. K., Kaul, A., Putnam, P. E., Rothenberg, M. E. and Mishra, A.
(2010). Interleukin-15
expression is increased in human eosinophilic esophagitis and mediates
pathogenesis in mice. Gastroenterology 139(1): 182-193. e187.
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Caldwell, J. M., Blanchard, C., Collins, M. H.,
Putnam, P. E., Kaul, A., Aceves, S. S., Bouska, C. A. and Rothenberg, M. E.
(2010). Glucocorticoid-regulated
genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin
Immunol 125(4): 879-888 e878.
-
Rothenberg, M. E., Spergel, J. M., Sherrill, J.
D., Annaiah, K., Martin, L. J., Cianferoni, A., Gober, L., Kim, C., Glessner,
J., Frackelton, E., Thomas, K., Blanchard, C., Liacouras, C., Verma, R.,
Aceves, S., Collins, M. H., Brown-Whitehorn, T., Putnam, P. E., Franciosi, J.
P., Chiavacci, R. M., Grant, S. F., Abonia, J. P., Sleiman, P. M. and
Hakonarson, H. (2010). Common
variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat
Genet 42(4): 289-291.
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Blanchard, C., Stucke, E. M., Burwinkel, K.,
Caldwell, J. M., Collins, M. H., Ahrens, A., Buckmeier, B. K., Jameson, S. C.,
Greenberg, A. and Kaul, A. (2010). Coordinate interaction
between IL-13 and epithelial differentiation cluster genes in eosinophilic
esophagitis. The Journal of Immunology 184(7): 4033-4041.
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Zhu, H., Mingler, M. K., McBride, M. L.,
Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Williams, M. T., Vorhees,
C. V. and Rothenberg, M. E. (2010). Abnormal response to stress
and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone
increase in mice lacking NPSR1. Psychoneuroendocrinology 35(8):
1119-1132.
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Finkelman, F. D., Boyce, J. A., Vercelli, D.
and Rothenberg, M. E. (2010). Key advances in mechanisms
of asthma, allergy, and immunology in 2009. J Allergy Clin Immunol 125(2): 312-318.
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Finkelman, F. D., Hogan, S. P., Hershey, G. K.,
Rothenberg, M. E. and Wills-Karp, M. (2010). Importance of cytokines in
murine allergic airway disease and human asthma. J Immunol 184(4): 1663-1674.
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Vicario, M., Blanchard, C., Stringer, K. F.,
Collins, M. H., Mingler, M. K., Ahrens, A., Putnam, P. E., Abonia, J. P.,
Santos, J. and Rothenberg, M. E. (2010). Local B cells and IgE
production in the oesophageal mucosa in eosinophilic oesophagitis. Gut 59(1): 12-20.
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Ingerski, L. M., Modi, A. C., Hood, K. K., Pai,
A. L., Zeller, M., Piazza-Waggoner, C., Driscoll, K. A., Rothenberg, M. E.,
Franciosi, J. and Hommel, K. A. (2010). Health-related quality of
life across pediatric chronic conditions. J Pediatr 156(4): 639-644.
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Uygungil, B., Bleesing, J. J., Risma, K. A.,
McNeal, M. M. and Rothenberg, M. E. (2010). Persistent rotavirus vaccine
shedding in a new case of severe combined immunodeficiency: A reason to screen. J Allergy Clin Immunol 125(1): 270-271.
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Gao, P. S., Shimizu, K., Grant, A. V., Rafaels,
N., Zhou, L. F., Hudson, S. A., Konno, S., Zimmermann, N., Araujo, M. I.,
Ponte, E. V., Cruz, A. A., Nishimura, M., Su, S. N., Hizawa, N., Beaty, T. H.,
Mathias, R. A., Rothenberg, M. E., Barnes, K. C. and Bochner, B. S. (2010). Polymorphisms in the sialic
acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with
susceptibility to asthma. Eur J Hum Genet 18(6): 713-719.
-
Herbert, D. R., Yang, J. Q., Hogan, S. P.,
Groschwitz, K., Khodoun, M., Munitz, A., Orekov, T., Perkins, C., Wang, Q.,
Brombacher, F., Urban, J. F., Jr., Rothenberg, M. E. and Finkelman, F. D.
(2009). Intestinal
epithelial cell secretion of RELM-beta protects against gastrointestinal worm
infection. J Exp Med 206(13): 2947-2957.
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Ogbogu, P. U., Bochner, B. S., Butterfield, J.
H., Gleich, G. J., Huss-Marp, J., Kahn, J. E., Leiferman, K. M., Nutman, T. B.,
Pfab, F., Ring, J., Rothenberg, M. E., Roufosse, F., Sajous, M. H., Sheikh, J.,
Simon, D., Simon, H. U., Stein, M. L., Wardlaw, A., Weller, P. F. and Klion, A.
D. (2009). Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical
characteristics and response to therapy. J Allergy Clin Immunol 124(6): 1319-1325 e1313.
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Rothenberg, M. E. and Daeron, M. (2009). Hypersensitivity and
allergy: from mice to men. Curr Opin Immunol 21(6): 658-659.
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Kottyan, L. C., Collier, A. R., Cao, K. H.,
Niese, K. A., Hedgebeth, M., Radu, C. G., Witte, O. N., Khurana Hershey, G. K.,
Rothenberg, M. E. and Zimmermann, N. (2009). Eosinophil viability is
increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood 114(13): 2774-2782.
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Rothenberg, M. E. (2009). Biology and treatment of
eosinophilic esophagitis. Gastroenterology 137(4): 1238-1249.
-
Takeda, A., Baffi, J. Z., Kleinman, M. E., Cho,
W. G., Nozaki, M., Yamada, K., Kaneko, H., Albuquerque, R. J., Dridi, S.,
Saito, K., Raisler, B. J., Budd, S. J., Geisen, P., Munitz, A., Ambati, B. K.,
Green, M. G., Ishibashi, T., Wright, J. D., Humbles, A. A., Gerard, C. J.,
Ogura, Y., Pan, Y., Smith, J. R., Grisanti, S., Hartnett, M. E., Rothenberg, M.
E. and Ambati, J. (2009). CCR3
is a target for age-related macular degeneration diagnosis and therapy. Nature 460(7252): 225-230.
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Yamada, Y., Cancelas, J. A. and Rothenberg, M.
E. (2009). Murine model
of hypereosinophilic syndromes/chronic eosinophilic leukemia. Int Arch
Allergy Immunol 149 Suppl 1: 102-107.
-
Niese, K. A., Collier, A. R., Hajek, A. R.,
Cederbaum, S. D., O'Brien, W. E., Wills-Karp, M., Rothenberg, M. E. and
Zimmermann, N. (2009). Bone
marrow cell derived arginase I is the major source of allergen-induced lung
arginase but is not required for airway hyperresponsiveness, remodeling and
lung inflammatory responses in mice. BMC immunology 10(1): 33.
-
Putnam, P. E. and Rothenberg, M. E. (2009). Eosinophilic esophagitis:
concepts, controversies, and evidence. Curr Gastroenterol Rep 11(3):
220-225.
-
Lu, T. X., Munitz, A. and Rothenberg, M. E.
(2009). MicroRNA-21 is
up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol 182(8): 4994-5002.
-
Rothenberg, M. E. (2009). Molecular diagnostics and
treatment of patients with the hypereosinophilic syndrome. Clin Adv
Hematol Oncol 7(1): 43-44.
-
Blanchard, C. and Rothenberg, M. E. (2009). Biology of the eosinophil. Adv Immunol 101: 81-121.
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Munitz, A., Seidu, L., Cole, E. T., Ahrens, R.,
Hogan, S. P. and Rothenberg, M. E. (2009). Resistin-like molecule alpha
decreases glucose tolerance during intestinal inflammation. J Immunol 182(4): 2357-2363.
-
Pentiuk, S., Putnam, P. E., Collins, M. H. and
Rothenberg, M. E. (2009). Dissociation
between symptoms and histological severity in pediatric eosinophilic
esophagitis. Journal of pediatric gastroenterology and nutrition 48(2): 152.
-
Miyazaki, D., Nakamura, T., Ohbayashi, M., Kuo,
C. H., Komatsu, N., Yakura, K., Tominaga, T., Inoue, Y., Higashi, H., Murata,
M., Takeda, S., Fukushima, A., Liu, F. T., Rothenberg, M. E. and Ono, S. J. (2009). Ablation of type I
hypersensitivity in experimental allergic conjunctivitis by eotaxin-1/CCR3
blockade. Int Immunol 21(2): 187-201.
-
Blanchard, C. and Rothenberg, M. E. (2009). Chemotactic factors
associated with eosinophilic gastrointestinal diseases. Immunol Allergy
Clin North Am 29(1): 141-148, xi.
-
Rothenberg,
M. E. and Stein, M. (2009). Reply. J Allergy Clin Immunol 123:269-70.
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Brandt, E. B., Munitz, A., Orekov, T., Mingler,
M. K., McBride, M., Finkelman, F. D. and Rothenberg, M. E. (2009). Targeting IL-4/IL-13
signaling to alleviate oral allergen-induced diarrhea. J Allergy Clin
Immunol 123(1): 53-58.
Book chapters
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Wen, T. and Rothenberg, M. E. Eosinophils. Mucosal Immunology 4th edition. Elsevier Science. (In press)
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Yoshiyuki, Y., Cancelas, J. A. and Rothenberg, M. E. Eosinophilic Leukemia Models. Eosinophils in Health and Disease. (In press)
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DeBrosse, C. W. and Rothenberg, M. E. Allergy and Eosinophil-associated Gastrointestinal Disorders. Current Opinions in Immunology. (In press)
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Rothenberg, M. E. (2014). Eosinophilic smdromes. In: Goldman, L. and Schafer, A. I. (eds). Goldman's Cecil Medicine, 25th Edition. Elsevier/Saunders.
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Rothenberg, M. E. Eosinophilic Gastroentrointestinal Disorders. (2013). In: Adkinson, N. F., Busse, W. W., Bochner, B. S., Holgate, S. T., Simons, F. E. R. and Lemanske, R. F. (eds). Middleton's Allergy: Principles and Practice, (8th Edition). Elsevier,1095-1104.
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Rothenberg, M. E. (2012). Eosinophilic smdromes. In: Goldman, L. and Schafer, A. I. (eds). Goldman's Cecil Medicine, 24th Edition. Elsevier/Saunders, 1118-1121.
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DeBrosse, C. W. and Rothenberg, M. E. (2012). Eosinophilia: Clinical Manifestations and Therapeutic Options. In: Holgate, S. T., Church, M. K., Broide, D. H. and Martinez, F. D. (eds). Allergy, 49‘ Edition. Elsevier/Saunders, 361-368.
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Rothenberg, M. E., Pentiuk, S. and Putnam, P. (2012). Gastroesophageal Reflux Disease and Eosinophilic Esophagitis in Children with Complex Airway Disease. In: Wilmott, R. W., Boat, T. F., Bush, A., Chernick, V., Deterding, R. R. and Ratjen, F. (eds). Kendig and Chemick's Disorders of the Respiratory Track in Children, 8th Edition. Elsevier/Saunder. 966-968.
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Davis, B. P. and Rothenberg, M. E. (2012). The Roles of Eosinophils in Human Disease: Eosinophils and GI Disease. In: Lee, I. l. and Rosenberg, H. F. (eds). Eosinophils in Health and Disease. Elsevier, 484-493.
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Sherrill, I. D. and Rothenberg, M. E. (2012). The Genetic Basis of Eosinophilic Esophagitis. In: Liacouras, C. A. and Markowitz, J. E. (eds). Eosinophilic Esophagitis. Clinical Gastroenterology. Springer, 97-106.
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Blanchard, C. and Rothenberg, M. E. (2009). Chemotactic Factors Associated with Eosinophilic Gastrointestinal Diseases. In: Furuta, G. T., Atkins, D. and Alam, R. (eds). Immunology and Allergy Clinics of North America. WB Saunders. 141-148.
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Rothenberg, M. E. (2008). Biology of Eosinophils. In: Adkinson, N. F., Busse, W. W., Bochner, B. S., Holgate, S. T., Simons, F. E. R., Lemanske, R. F. (eds). Middleton's Allergy: Principles and Practice, 7th Edition. Elsevier.
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Rothenberg, M. E. (2009). Eosinophilic Gastroenteropathies. In: Adkinson, Ir. N. F., Busse, W. W., Bochner, B. S., Holgate, S. T., Simons, F. E. R. and Lemanske, Ir. R. F. (eds). Middleton's Allergy: Principles and Practice, 7th Edition. Elsevier. 879-888.
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Rothenberg, M. E. and Furuta, G. T. (2009). Eosinophilic Esophagitis. In: Yamada, T. (ed), Alpers, D. H., Kalloo, A., Kaplowitz, N. and Owyang, C., Powell, D. (associate editors). Textbook of Gastroenterology (Sm Edition). Blackwell Publishing, 802-812.
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Li, Z. and Rothenberg, M. E. (2008). Eosinophil Associated Gastrointestinal Disorders IEGIDI. In: Rich, R. R., Shearer, W. T., Fleisher, T. A., Schroeder, H., Weyand, C., Frew, A. I. (eds). Clinical Immunology, 3"3 Edition. Martin Mellor Publishing Services.
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Fulkerson, P. C. and Rothenberg, M. E. (2008). Eosinophilia and Eosinophilic Disorders. In: Mahmoudi, M. (ed). Challenging Cases in Allergy and Immunology. Humana Press.
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Rothenberg, M. E. (2007). Eosinophilic Smdromes. In: Goldman, L. and Ausiello, D. (eds). Cecil Medicine: Expert Consult: Online and Print (Cecil Textbook of Medicine), 23th Edition. WB Saunders.
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Fulkerson, P. C. and Rothenberg, M. E. (2006). Chemokines CXC: CXCL9 lmigl. In: Laurent G. J., Shapiro, S. D. (eds). Encyclopedia of Respiratory Medicine. Elsevier Science. 398-401.
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Rothenberg, M. E. (2005). Eosinophils. In: Mestecky, I., Bienenstock, I., Lamm, M. E., Mayer, L., McGhee, I. R. and Strober, W. (eds). Mucosal Immunology, Volume I. Elsevier Science. 717-735.
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Rothenberg, M. E. (2003). Inflammatogg Effector Cells[Cell Migration. In: Leung, D. Y. M., Geha, R., Sampson, H. and Szefler, A. (eds). Pediatric Allergy: Principles and Practice. Mosby. 51-68.
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Guajardo, I. R. and Rothenberg, M. E. (2003). Eosinophilic Esophagjtis, Gastroenteritis, Gastroenterocolitis, and Colitis. In: Metcalfe, D., Sampson, H. and Simon, R. A. (eds). Food Allergy: Adverse Reactions to Foods and Food Additives, 3th Edition. Blackwell Publishing, 217-226.
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Zimmermann, N. and Rothenberg, M. E. (2003). Role of the Eotaxin Subfamily of Chemokines in Allergic Eosinophilic Inflammation. In: Eissa, N. T., Huston, D. P. and Lenfant, C. (eds). Lung Biology in Health and Disease: Therapeutic Targets of Airway Inflammation. Marcel Dekker, 421-463.
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Zimmermann, N. and Rothenberg, M. E. (2002). Therapeutic Targeting of Chemokines and Chemokine Receptors. In: Agosti, I., Sheffer, A. L. (eds). Biotherapeutic Approaches to Asthma. Marcel Dekker, 167-210.
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Rothenberg, M. E. (2002). Eotaxin. In: Creighton, T. E. (ed). The Encyclopedia of Molecular Medicine. Iohn Wiley & Sons, 1181-1185.
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Assa'ad, A. H., Spicer, R. L., Nelson, D. P., Zimmermann, N. and Rothenberg, M. E. (2000). Hypereosinophilic Syndromes. In: Marone, G. (ed). Human Eosinophils: Biologic and Clinical Aspects, Volume 76. AG Basel, 208-229.
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Zimmermann, N. and Rothenberg, M. E. (2000). Eosinophil Chemokines. In: Rothenberg, M. E. (ed). Chemokines in Allergic Disease. Marcel Dekker,151-171.
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Murphy, P. M. and Rothenberg, M. E. (2000). Chemokine Receptors. In: Rothenberg, M. E. (ed). Chemokines in Allergic Disease. Marcel Dekker, 53-66.
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Rothenberg, M. E. and Hogan, S. P. (2000). Introduction. In: Rothenberg, M. E. (ed). Chemokines in Allergic Disease. Marcel Dekker, 1-15.
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Rothenberg, M. E. (2000). Chemokine Knockout Mice. In: Proudfoot, A. (ed). Methods in Molecular Biology, Volume 138: Chemokine Protocols. New Jersey, 253-257.
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Rothenberg, M. E. Eotaxin. (1998). In: Aggarwal, B. (ed). Human Cytokines: Handbook for Basic and Clinical Research, Volume III. Blackwell Science, 383-399.
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Rothenberg, M. E. and Austen, K. F. (1989). Influence of the fibroblast environment on the structure of mast cell proteoglycans. Ann N YAcad Sci., 233-244.
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Rothenberg, M. E. and Austen, K. F. (1988). Reglation of human eosinophil phenotype. In: Hadden, J. W. et al. (eds). Advances in Immunopharmacology 4. Pergamon Press, 231-237.
Author/ Editor textbooks
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Rothenberg, M. E., editor of Chemokines in Allergic Diseases, Marcel Dekker, 1999.