Education
Ph.D. in Oncology, Zhejiang University, China, 2003
Current position
Senior Research Fellow in Cancer and Inflammation Program, NCI-Frederick/NIH, Frederick, Maryland
Publications
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Xiao, Z., Jiang, Q., Willette-Brown, J., Xi, S., Zhu, F., Burkett, S., Back, T., Song, N. Y., Datla, M., Sun, Z., Goldszmid, R., Lin, F., Cohoon, T., Pike, K., Wu, X., Schrump, D. S., Wong, K. K., Young, H. A., Trinchieri, G., Wiltrout, R. H. and Hu, Y. (2013). The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas. Cancer Cell 23(4): 527-540.
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Xia, X.*, Liu, S.*, Xiao, Z.*, Zhu, F., Song, N. Y., Zhou, M., Liu, B., Shen, J., Nagashima, K., Veenstra, T. D., Burkett, S., Datla, M., Willette-Brown, J., Shen, H. and Hu, Y. (2013). An IKKalpha-nucleophosmin axis utilizes inflammatory signaling to promote genome integrity. Cell Rep 5(5): 1243-1255. *These authors contributed equally
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Xiao, Z., Jiang, Q., Willette-Brown, J. and Hu, Y. (2013). Mouse model resembling human lung cancer. Oncotarget. (Epub ahead of print)
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Xiao, Z., Mohamood, A. S., Uddin, S., Gutfreund, R., Nakata, C., Marshall, A., Kimura, H., Caturegli, P., Womer, K. L., Huang, Y., Jie, C., Chakravarti, S., Schneck, J. P., Yagita, H. and Hamad, A. R. (2011). Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development. Am J Pathol 179(2): 725-732.
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Hamad, A. R., Xiao, Z., Li, M., Schneck, J., and Mohamood, A. (2009). Correlating expression of syndecan 1, a novel marker for certain thymocyte with development into unique alpha/beta T cell lineages. J Immunol 182: 86-93.
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Stanley, B. J., Ehrlich, E. S., Short, L., Yu, Y., Xiao, Z., Yu, X. F. and Xiong, Y. (2008). Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly. J Virol 82(17): 8656-8663.
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Mohamood, A. S., Bargatze, D., Xiao, Z., Jie, C., Yagita, H., Ruben, D., Watson, J., Chakravarti, S., Schneck, J. P. and Hamad, A. R. (2008). Fas-mediated apoptosis regulates the composition of peripheral alphabeta T cell repertoire by constitutively purging out double negative T cells. PLoS One 3(10): e3465.
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Xiao, Z., Ehrlich, E., Luo, K., Xiong, Y. and Yu, X. F. (2007). Zinc chelation inhibits HIV Vif activity and liberates antiviral function of the cytidine deaminase APOBEC3G. FASEB J 21(1): 217-222.
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Xiao, Z., Xiong, Y., Zhang, W., Tan, L., Ehrlich, E., Guo, D. and Yu, X. F. (2007). Characterization of a novel Cullin5 binding domain in HIV-1 Vif. J Mol Biol 373(3): 541-550.
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Mohamood, A. S., Guler, M. L., Xiao, Z., Zheng, D., Hess, A., Wang, Y., Yagita, H., Schneck, J. P. and Hamad, A. R. (2007). Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically. Am J Pathol 171(1): 97-106.
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Yu, Y.*, Xiao, Z.*, Ehrlich, E. S., Yu, X. and Yu, X. F. (2004). Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines. Genes Dev 18(23): 2867-2872. *These authors contributed equally
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Luo, K., Ehrlich, E., Xiao, Z., Zhang, W., Ketner, G. and Yu, X. F. (2007). Adenovirus E4orf6 assembles with Cullin5-ElonginB-ElonginC E3 ubiquitin ligase through an HIV/SIV Vif-like BC-box to regulate p53. FASEB J 21(8): 1742-1750.
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Luo, K., Wang, T., Liu, B., Tian, C., Xiao, Z., Kappes, J. and Yu, X. F. (2007). Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation. J Virol 81(13): 7238-7248.
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Xiao, Z., Ehrlich, E., Yu, Y., Luo, K., Wang, T., Tian, C. and Yu, X. F. (2006). Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif. Virology 349(2): 290-299.
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Luo, K., Xiao, Z., Ehrlich, E., Yu, Y., Liu, B., Zheng, S. and Yu, X. F. (2005). Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G. Proc Natl Acad Sci U S A 102(32): 11444-11449.
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Luo, K., Liu, B., Xiao, Z., Yu, Y., Yu, X., Gorelick, R. and Yu, X. F. (2004). Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging. J Virol 78(21): 11841-11852.
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Zheng, S., Xiao, Z. X., Pan, Y. L., Han, M. Y. and Dong, Q. (2003). Continuous release of interleukin 12 from microencapsulated engineered cells for colon cancer therapy. World J Gastroenterol 9(5): 951-955.
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Zheng, S., Han, M. Y., Xiao, Z. X., Peng, J. P. and Dong, Q. (2003). Clinical significance of vascular endothelial growth factor expression and neovascularization in colorectal carcinoma. World J Gastroenterol 9(6): 1227-1230.