Michael Quante
  • II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Germany
Research focus
  • Cell biology
Personal information


Ph.D., Department of Medicine, University of Freiburg, 2009
M.D., School of Medicine, Heinrich Heine Universität, Düsseldorf, 2009

Current position

Clinical Fellow and Principal Investigator, II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München


  1. Westphalen, C. B., Asfaha, S., Hayakawa, Y., Takemoto, Y., Lukin, D. J., Nuber, A. H., Brandtner, A., Setlik, W., Remotti, H., Muley, A., Chen, X., May, R., Houchen, C. W., Fox, J. G., Gershon, M. D., Quante, M. and Wang, T. C. (2014). Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest 124(3): 1283-1295.
  2. Quante, M., Abrams, J. A. and Wang, T. C. (2013). The rapid rise in gastroesophageal junction tumors: is inflammation of the gastric cardia the underwater iceberg? Gastroenterology 145(4): 708-711.
  3. Tanzer, M., Liebl, M. and Quante, M. (2013). Molecular biomarkers in esophageal, gastric, and colorectal adenocarcinoma. Pharmacol Ther 140(2): 133-147.
  4. Quante, M., Varga, J., Wang, T. C. and Greten, F. R. (2013). The gastrointestinal tumor microenvironment. Gastroenterology 145(1): 63-78.
  5. Worthley, D. L., Si, Y., Quante, M., Churchill, M., Mukherjee, S. and Wang, T. C. (2013). Bone marrow cells as precursors of the tumor stroma. Exp Cell Res. (Epub ahead of print)
  6. Shakya, R., Gonda, T., Quante, M., Salas, M., Kim, S., Brooks, J., Hirsch, S., Davies, J., Cullo, A., Olive, K., Wang, T. C., Szabolcs, M., Tycko, B. and Ludwig, T. (2013). Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma. Cancer Res 73(2): 885-896.
  7. Quante, M., Abrams, J. A., Lee, Y. and Wang, T. C. (2012). Barrett esophagus: what a mouse model can teach us about human disease. Cell Cycle 11(23): 4328-4338.
  8. Shibata, W., Ariyama, H., Westphalen, C. B., Worthley, D. L., Muthupalani, S., Asfaha, S., Dubeykovskaya, Z., Quante, M., Fox, J. G. and Wang, T. C. (2013). Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors. Gut 62(2): 192-200.
  9. Quante, M., Bhagat, G., Abrams, J. A., Marache, F., Good, P., Lee, M. D., Lee, Y., Friedman, R., Asfaha, S., Dubeykovskaya, Z., Mahmood, U., Figueiredo, J. L., Kitajewski, J., Shawber, C., Lightdale, C. J., Rustgi, A. K. and Wang, T. C. (2012). Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell 21(1): 36-51.
  10. Green, D. A., Mlynarczyk, C. M., Vaccaro, B. J., Capiak, K. M., Quante, M., Lightdale, C. J. and Abrams, J. A. (2011). Correlation between serum gastrin and cellular proliferation in Barrett's esophagus. Therap Adv Gastroenterol 4(2): 89-94.
  11. Quante, M., Tu, S. P., Tomita, H., Gonda, T., Wang, S. S., Takashi, S., Baik, G. H., Shibata, W., Diprete, B., Betz, K. S., Friedman, R., Varro, A., Tycko, B. and Wang, T. C. (2011). Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell 19(2): 257-272.
  12. Tu, S. P.*, Quante, M.*, Bhagat, G., Takaishi, S., Cui, G., Yang, X. D., Muthuplani, S., Shibata, W., Fox, J. G. and Pritchard, D. M. (2011). IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis. Cancer research 71(12): 4247-4259.
  13. Takaishi, S., Shibata, W., Tomita, H., Jin, G., Yang, X., Ericksen, R., Dubeykovskaya, Z., Asfaha, S., Quante, M., Betz, K. S., Shulkes, A. and Wang, T. C. (2011). In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice. Am J Physiol Gastrointest Liver Physiol 300(2): G334-344.
  14. Heeg, S., Hirt, N., Queisser, A., Schmieg, H., Thaler, M., Kunert, H., Quante, M., Goessel, G., von Werder, A., Harder, J., Beijersbergen, R., Blum, H. E., Nakagawa, H. and Opitz, O. G. (2011). EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis. Cancer Sci 102(2): 351-360.
  15. Quante, M., Marrache, F., Goldenring, J. R. and Wang, T. C. (2010). TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology 139(6): 2018-2027 e2012.
  16. Song, Z., Bhagat, G., Quante, M., Baik, G. H., Marrache, F., Tu, S. P., Zhao, C. M., Chen, D., Dannenberg, A. J. and Wang, T. C. (2010). Potential carcinogenic effects of cigarette smoke and Swedish moist snuff on pancreas: a study using a transgenic mouse model of chronic pancreatitis. Lab Invest 90(3): 426-435.
  17. Quante, M. and Wang, T. C. (2009). Stem cells in gastroenterology and hepatology. Nat Rev Gastroenterol Hepatol 6(12): 724-737.
  18. Jin, G., Ramanathan, V., Quante, M., Baik, G. H., Yang, X., Wang, S. S., Tu, S., Gordon, S. A., Pritchard, D. M., Varro, A., Shulkes, A. and Wang, T. C. (2009). Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. J Clin Invest 119(9): 2691-2701.
  19. Tu, S. P., Chi, A. L., Ai, W., Takaishi, S., Dubeykovskaya, Z., Quante, M., Fox, J. G. and Wang, T. C. (2009). p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells. Am J Physiol Gastrointest Liver Physiol 297(2): G385-396.
  20. Quante, M., Raskopf, E., Stahl, S., Vogt, A., Sauerbruch, T. and Schmitz, V. (2009). No functional and transductional significance of specific neuropilin 1 siRNA inhibition in colon carcinoma cell lines lacking VEGF receptor 2. Oncol Rep 21(5): 1161-1168.
  21. Quante, M., Appenrodt, B., Randerath, S., Wolff, M., Fischer, H. P. and Sauerbruch, T. (2009). Atypical Ormond's disease associated with bile duct stricture mimicking cholangiocarcinoma. Scand J Gastroenterol 44(1): 116-120.
  22. Quante, M. and Wang, T. C. (2008). Inflammation and stem cells in gastrointestinal carcinogenesis. Physiology (Bethesda) 23: 350-359.
  23. Goessel, G., Quante, M., Hahn, W. C., Harada, H., Heeg, S., Suliman, Y., Doebele, M., von Werder, A., Fulda, C., Nakagawa, H., Rustgi, A. K., Blum, H. E. and Opitz, O. G. (2005). Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis. Proc Natl Acad Sci U S A 102(43): 15599-15604.
  24. Quante, M., Heeg, S., von Werder, A., Goessel, G., Fulda, C., Doebele, M., Nakagawa, H., Beijersbergen, R., Blum, H. E. and Opitz, O. G. (2005). Differential transcriptional regulation of human telomerase in a cellular model representing important genetic alterations in esophageal squamous carcinogenesis. Carcinogenesis 26(11): 1879-1889.
  25. Opitz, O. G., Quante, M., von Werder, A., Heeg, S. and Blum, H. E. (2005). A mouse model of oral-esophageal carcinogenesis. Onkologie 28(1): 44-48.
    *Authors are equally contributed
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