Marc A. Kerenyi
  • Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, USA
Research fields
  • Stem cell
Personal information


Ph.D. in Molecular Biology, University of Vienna, 2008

Current position

Senior Research Fellow in Hematology/Oncology, Cancer and Blood Disorders Center of Boston Children’s Hospital and Dana Farber Cancer Center, Division of Hematology/Oncology, Harvard Medical School, Boston, USA

Publications (since 2006)

  1. Guo, G., Luc, S., Marco, E., Lin, T. W., Peng, C., Kerenyi, M. A., Beyaz, S., Kim, W., Xu, J., Das, P. P., Neff, T., Zou, K., Yuan, G. C. and Orkin, S. H. (2013). Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell 13(4): 492-505.
  2. Kim, W., Bird, G. H., Neff, T., Guo, G., Kerenyi, M. A., Walensky, L. D. and Orkin, S. H. (2013). Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol 9(10): 643-650.
  3. Kerenyi, M. A., Shao, Z., Hsu, Y. J., Guo, G., Luc, S., O'Brien, K., Fujiwara, Y., Peng, C., Nguyen, M. and Orkin, S. H. (2013). Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife 2: e00633.
  4. Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y. J., Yao, H., Trowbridge, J. J., Mandel, G. and Orkin, S. H. (2013). Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci U S A 110(16): 6518-6523.
  5. Staber, P. B., Zhang, P., Ye, M., Welner, R. S., Nombela-Arrieta, C., Bach, C., Kerenyi, M., Bartholdy, B. A., Zhang, H., Alberich-Jorda, M., Lee, S., Yang, H., Ng, F., Zhang, J., Leddin, M., Silberstein, L. E., Hoefler, G., Orkin, S. H., Gottgens, B., Rosenbauer, F., Huang, G. and Tenen, D. G. (2013). Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Mol Cell 49(5): 934-946.
  6. Kovacic, B., Hoelbl, A., Litos, G., Alacakaptan, M., Schuster, C., Fischhuber, K. M., Kerenyi, M. A., Stengl, G., Moriggl, R., Sexl, V. and Beug, H. (2012). Diverging fates of cells of origin in acute and chronic leukaemia. EMBO Mol Med 4(4): 283-297.
  7. Kerenyi, M. A. and Orkin, S. H. (2010). Networking erythropoiesis. J Exp Med 207(12): 2537-2541.
  8. Friedbichler, K., Kerenyi, M. A., Kovacic, B., Li, G., Hoelbl, A., Yahiaoui, S., Sexl, V., Mullner, E. W., Fajmann, S., Cerny-Reiterer, S., Valent, P., Beug, H., Gouilleux, F., Bunting, K. D. and Moriggl, R. (2010). Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation. Blood 116(9): 1548-1558.
  9. Naetar, N., Korbei, B., Kozlov, S., Kerenyi, M. A., Dorner, D., Kral, R., Gotic, I., Fuchs, P., Cohen, T. V., Bittner, R., Stewart, C. L. and Foisner, R. (2008). Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation. Nat Cell Biol 10(11): 1341-1348.
  10. Kerenyi, M. A., Grebien, F., Gehart, H., Schifrer, M., Artaker, M., Kovacic, B., Beug, H., Moriggl, R. and Mullner, E. W. (2008). Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood 112(9): 3878-3888.
  11. Harir, N., Boudot, C., Friedbichler, K., Sonneck, K., Kondo, R., Martin-Lanneree, S., Kenner, L., Kerenyi, M., Yahiaoui, S., Gouilleux-Gruart, V., Gondry, J., Benit, L., Dusanter-Fourt, I., Lassoued, K., Valent, P., Moriggl, R. and Gouilleux, F. (2008). Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade. Blood 112(6): 2463-2473.
  12. Kornfeld, J. W., Grebien, F., Kerenyi, M. A., Friedbichler, K., Kovacic, B., Zankl, B., Hoelbl, A., Nivarti, H., Beug, H., Sexl, V., Muller, M., Kenner, L., Mullner, E. W., Gouilleux, F. and Moriggl, R. (2008). The different functions of Stat5 and chromatin alteration through Stat5 proteins. Front Biosci 13: 6237-6254.
  13. Grebien, F., Kerenyi, M. A., Kovacic, B., Kolbe, T., Becker, V., Dolznig, H., Pfeffer, K., Klingmuller, U., Muller, M., Beug, H., Mullner, E. W. and Moriggl, R. (2008). Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood 111(9): 4511-4522.
  14. Yao, Z., Kanno, Y., Kerenyi, M., Stephens, G., Durant, L., Watford, W. T., Laurence, A., Robinson, G. W., Shevach, E. M., Moriggl, R., Hennighausen, L., Wu, C. and O'Shea, J. J. (2007). Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109(10): 4368-4375.
  15. Harir, N., Pecquet, C., Kerenyi, M., Sonneck, K., Kovacic, B., Nyga, R., Brevet, M., Dhennin, I., Gouilleux-Gruart, V., Beug, H., Valent, P., Lassoued, K., Moriggl, R. and Gouilleux, F. (2007). Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood 109(4): 1678-1686.
  16. Hoelbl, A., Kovacic, B., Kerenyi, M. A., Simma, O., Warsch, W., Cui, Y., Beug, H., Hennighausen, L., Moriggl, R. and Sexl, V. (2006). Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. Blood 107(12): 4898-4906.
  17. Dolznig, H., Grebien, F., Deiner, E. M., Stangl, K., Kolbus, A., Habermann, B., Kerenyi, M. A., Kieslinger, M., Moriggl, R., Beug, H. and Mullner, E. W. (2006). Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR. Oncogene 25(20): 2890-2900.
  18. Holnthoner, W., Kerenyi, M., Groger, M., Kratochvill, F. and Petzelbauer, P. (2006). Regulation of matrilysin expression in endothelium by fibroblast growth factor-2. Biochem Biophys Res Commun 342(3): 725-733.

Books & Commentaries

  1. Kerenyi, M. and Mullner, E. W. (2009). Muscle iron in stress erythropoiesis? Blood 113(26): 6507-6508.
  2. Kerenyi, M. A. and Mullner, E. W. (2009). MYB and miR: a pair well matched. Blood 113(3): 499-500.
  3. Friedbichler, K., Kerenyi, M. A., Mullner, E. W., Moriggl, R. (2008). Chapter: Stat5 as Hematopoietic Gatekeeper and Oncogene Upon Tyrosine Kinase-Induced Transformation. JAK STAT Pathway in Disease. (edited by Anastasis Stephanou) (Landes Bioscience 2008)
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