Jeroen D. Langereis
  • Laboratory of Pediatric Infectious Diseases, Department of Pediatrics and Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Centre, The Netherlands
Research fields
  • Microbiology
Personal information


Ph.D. in Immunology, Department of Respiratory Medicine, Medical Center, Utrecht, the Netherlands, 2010

Current position

Postdoctoral Fellow, Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA


  1. Short, K. R., von Kockritz-Blickwede, M., Langereis, J. D., Chew, K. Y., Job, E. R., Armitage, C. W., Hatcher, B., Fujihashi, K., Reading, P. C., Hermans, P. W., Wijburg, O. L. and Diavatopoulos, D. A. (2014). Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis media. Infect Immun 82(1): 364-370.
  2. Langereis, J. D. # (2013). Neutrophil integrin affinity regulation in adhesion, migration, and bacterial clearance. Cell Adh Migr 7(6): 476-481. (Invited review) #Corresponding author
  3. Kamp, V. M., Langereis, J. D., van Aalst, C. W., van der Linden, J. A., Ulfman, L. H. and Koenderman, L. (2013). Physiological concentrations of leptin do not affect human neutrophils. PLoS One 8(9): e73170.
  4. de Kleijn, S.*, Langereis, J. D.* #, Leentjens, J., Kox, M., Netea, M. G., Koenderman, L., Ferwerda, G., Pickkers, P. and Hermans, P. W. (2013). IFN-gamma-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1. PLoS One 8(8): e72249. *Contributed equally; #Corresponding author
  5. Langereis, J. D.# and Hermans, P. W. (2013). Novel concepts in nontypeable Haemophilus influenzae biofilm formation. FEMS Microbiol Lett 346(2): 81-89. (Invited review) #Corresponding author
  6. Kamp, V. M., Leentjens, J., Pillay, J., Langereis, J. D., de Kleijn, S., Kox, M., Netea, M. G., Pickkers, P. and Koenderman, L. (2013). Modulation of granulocyte kinetics by GM-CSF/IFN-gamma in a human LPS rechallenge model. J Leukoc Biol 94(3): 513-520.
  7. Langereis, J. D.#, van Dongen, T. M., Stol, K., Venekamp, R. P., Schilder, A. G. and Hermans, P. W. (2013). Resistance to complement-mediated killing and IgM binding to non-typeable Haemophilus influenzae is not altered when ascending from the nasopharynx to the middle ears in children with otitis media. Med Microbiol Immunol 202(6): 407-415. #Corresponding author
  8. Langereis, J. D.#, Koenderman, L., Huttenlocher, A. and Ulfman, L. H. (2013). Gelsolin expression increases beta1 -integrin affinity and L1210 cell adhesion. Cytoskeleton (Hoboken) 70(7): 385-393. #Corresponding author
  9. Langereis, J. D., Zomer, A., Stunnenberg, H. G., Burghout, P. and Hermans, P. W. (2013). Nontypeable Haemophilus influenzae carbonic anhydrase is important for environmental and intracellular survival. J Bacteriol 195(12): 2737-2746.
  10. de Vries, S. P., Burghout, P., Langereis, J. D., Zomer, A., Hermans, P. W. and Bootsma, H. J. (2013). Genetic requirements for Moraxella catarrhalis growth under iron-limiting conditions. Mol Microbiol 87(1): 14-29.
  11. Langereis, J. D., Stol, K., Schweda, E. K., Twelkmeyer, B., Bootsma, H. J., de Vries, S. P., Burghout, P., Diavatopoulos, D. A. and Hermans, P. W. (2012). Modified lipooligosaccharide structure protects nontypeable Haemophilus influenzae from IgM-mediated complement killing in experimental otitis media. MBio 3(4): e00079-00012
  12. Langereis, J. D., Schweizer, R. C., Lammers, J. W., Koenderman, L. and Ulfman, L. H. (2011). A unique protein profile of peripheral neutrophils from COPD patients does not reflect cytokine-induced protein profiles of neutrophils in vitro. BMC Pulm Med 11: 44.
  13. Langereis, J. D., Franciosi, L., Ulfman, L. H. and Koenderman, L. (2011). GM-CSF and TNFalpha modulate protein expression of human neutrophils visualized by fluorescence two-dimensional difference gel electrophoresis. Cytokine 56(2): 422-429.
  14. Langereis, J. D., Oudijk, E. J., Schweizer, R. C., Lammers, J. W., Koenderman, L. and Ulfman, L. H. (2011). Steroids induce a disequilibrium of secreted interleukin-1 receptor antagonist and interleukin-1beta synthesis by human neutrophils. Eur Respir J 37(2): 406-415.
  15. Langereis, J. D., Raaijmakers, H. A., Ulfman, L. H. and Koenderman, L. (2010). Abrogation of NF-kappaB signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation. J Leukoc Biol 88(4): 655-664.
  16. Langereis, J. D., Prinsen, B. H., de Sain-van der Velden, M. G., Coppens, C. J., Koenderman, L. and Ulfman, L. H. (2009). A 2D-DIGE approach to identify proteins involved in inside-out control of integrins. J Proteome Res 8(8): 3824-3833.
  17. Oudijk, E. J., Lo Tam Loi, A. T., Langereis, J. D., Ulfman, L. H. and Koenderman, L. (2008). Functional antagonism by GM-CSF on TNF-alpha-induced CD83 expression in human neutrophils. Mol Immunol 46(1): 91-96.
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