Education
Ph.D., Department of Molecular Biology, Memorial Sloan-Kettering Cancer Center Division, Cornell University, NY, USA, 1995
Current position
Chief Scientific Advisor, Apta SSD Co. Ltd, Seoul, Korea (04/2013-present)
CSO, BexCore Inc., Seoul, Korea (08/2009-present)
Professor, Department of Molecular Biology, Institute of Nanosensor and Biotechnology,
Dankook University (03/1997-present)
Publications (since 2008)
Research articles
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Han, S. R. and Lee, S. W. (2013). In vitro selection of RNA aptamer specific to Salmonella typhimurium. J Microbiol Biotechnol 23(6): 878-884.
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Han, S. R. and Lee, S. W. (2013). In vitro selection of RNA aptamer specific to Salmonella typhimurium. J Microbiol Biotechnol 23(6): 878-884.
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Lee, C. H., Lee, Y. J., Kim, J. H., Lim, J. H., Han, W., Lee, S. H., Noh, G. J. and Lee, S. W. (2013). Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase. J Virol 87(12): 7064-7074. (Selected as ‘Press Release’ by American Society for Microbiology, http://www.asm.org/index.php/asm-newsroom2/88-news-room/journal-tipsheets/91691-new-agent-inhibits-hcv-replication-in-mouse-models-no-resistance-seen) (Selected in 'Highlights' section in the journal 'Microbe 2013, Vol. 8, No. 6, Page 241')
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Hong, H. W., Lee, S. W. and Myung, H. (2013). Induced degradation of Tat by nucleocapsid (NC) via the proteasome pathway and its effect on HIV transcription. Viruses 5(4): 1143-1152.
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Kwon, T., Park, J., Lee, G., Nam, K., Huh, Y.-M., Lee, S.-W., Yang, J., Lee, C. Y. and Eom, K. (2013). Carbon Nanotube-Patterned Surface-Based Recognition of Carcinoembryonic Antigens in Tumor Cells for Cancer Diagnosis. The Journal of Physical Chemistry Letters 4(7): 1126-1130.
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Maeng, J. S., Kim, N., Kim, C. T., Han, S. R., Lee, Y. J., Lee, S. W., Lee, M. H. and Cho, Y. J. (2012). Rapid detection of food pathogens using RNA aptamers-immobilized slide. J Nanosci Nanotechnol 12(7): 5138-5142.
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Lee, Y. J., Han, S. R., Kim, N. Y., Lee, S. H., Jeong, J. S. and Lee, S. W. (2012). An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice. Gastroenterology 143(1): 155-165 e158. (Selected and invited as Video Abstract, http://www.youtube.com/watch?v=UfnYhhW7Yb4&list=PL1DE0E0B4378B4525&index=3&feature=plpp_video)
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Won, Y. S. and Lee, S. W. (2012). Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme. J Biotechnol 158(1-2): 44-49.
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Won, Y. S. and Lee, S. W. (2012). Cancer-specific induction of adenoviral E1A expression by group I intron-based trans-splicing ribozyme. J Microbiol Biotechnol 22(3): 431-435.
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Lee, C. H., Kim, J. H., Kim, H. W., Myung, H. and Lee, S. W. (2012). Hepatitis C virus replication-specific inhibition of microRNA activity with self-cleavable allosteric ribozyme. Nucleic Acid Ther 22(1): 17-29.
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Lee, Y. J. and Lee, S. W. (2012). Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein. Biochem Biophys Res Commun 417(1): 521-527.
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Lee, Y. J., Han, S. R., Maeng, J. S., Cho, Y. J. and Lee, S. W. (2012). In vitro selection of Escherichia coli O157:H7-specific RNA aptamer. Biochem Biophys Res Commun 417(1): 414-420.
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Ban, G., Jeong, J.-S., and Lee, S.-W. (2011) In vivo target specificity of hCKAP2-replacing trans-splicing ribozyme. Journal of Nano & Bio Tech 8: 10-13.
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Lee, C. H., and Lee, S.-W. (2011) Inhibition of hepatitis C virus (HCV) replication by hammerhead ribozyme which activity can be allosterically regulated by HCV NS5B RNA replicase. The Korean Journal of Microbiology 47: 188-193.
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Ban, G., Jeong, J. S., Kim, A., Kim, S. J., Han, S. Y., Kim, I. H. and Lee, S. W. (2011). Selective and efficient retardation of cancers expressing cytoskeleton-associated protein 2 by targeted RNA replacement. Int J Cancer 129(4): 1018-1029. (Selected as a featured article in spotlight)
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Kwon, B. S., Jeong, J. S., Won, Y. S., Lee, C. H., Yoon, K. S., Hyung Jung, M., Kim, I. H. and Lee, S. W. (2011). Intracellular efficacy of tumor-targeting group I intron-based trans-splicing ribozyme. J Gene Med 13(2): 89-100.
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Hong, H. W., Lee, S. W. and Myung, H. (2010). Selection of peptides binding to HCV e2 and inhibiting viral infectivity. J Microbiol Biotechnol 20(12): 1769-1771.
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Ban, G., Kim, A., Kim, S., and Lee, S.-W. (2010) Accurate trans-splicing reaction in vivo by hCKAP2-targeting group I intron ribozyme. Journal of Nano & Bio Tech 7: 6-9.
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Chang, B., Lee, C. H., Lee, J. H. and Lee, S. W. (2010). Comparative analysis of intracellular inhibition of hepatitis C virus replication by small interfering RNAs. Biotechnol Lett 32(9): 1231-1237.
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Jeong, S., Han, S. R., Lee, Y. J., Kim, J. H. and Lee, S. W. (2010). Identification of RNA aptamer specific to mutant KRAS protein. Oligonucleotides 20(3): 155-161.
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Jeong, S., Han, S. R., Lee, Y. J. and Lee, S. W. (2010). Selection of RNA aptamers specific to active prostate-specific antigen. Biotechnol Lett 32(3): 379-385.
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Song, M. S. and Lee, S. W. (2009). RNA Mapping of Mutant Myotonic Dystrophy Protein Kinase 3'-Untranslated Region Transcripts. Genomics & Informatics 7(4): 181-186. (Selected as cover featured article)
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Kim, J.H., Ban, G., Won, Y.S., Kim, S.J., Won, R., and Lee, S.-W. (2009). Trans-splicing reaction in cells by mTERT-targeting group I intron. Journal of Nano & Bio Tech 6: 15-18.
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Cho, J. S. and Lee, S. W. (2009). Sequence and structural features of RNA aptamer against myasthenic autoantibodies. Oligonucleotides 19(3): 273-280.
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Ban, G., Song, M. S. and Lee, S. W. (2009). Cancer cell targeting with mouse TERT-specific group I intron of Tetrahymena thermophila. J Microbiol Biotechnol 19(9): 1070-1076.
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Ahn, D. G., Jeon, I. J., Kim, J. D., Song, M. S., Han, S. R., Lee, S. W., Jung, H. and Oh, J. W. (2009). RNA aptamer-based sensitive detection of SARS coronavirus nucleocapsid protein. Analyst 134(9): 1896-1901.
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Song, M. S., Jeong, J. S., Ban, G., Lee, J. H., Won, Y. S., Cho, K. S., Kim, I. H. and Lee, S. W. (2009). Validation of tissue-specific promoter-driven tumor-targeting trans-splicing ribozyme system as a multifunctional cancer gene therapy device in vivo. Cancer Gene Ther 16(2): 113-125. (Selected as a featured article)
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Hwang, B., Lim, J. H., Hahm, B., Jang, S. K. and Lee, S. W. (2009). hnRNP L is required for the translation mediated by HCV IRES. Biochem Biophys Res Commun 378(3): 584-588.
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Song, M.S., Jeong, J.-S., and Lee, S.-W. (2008) Inhibition of telomerase expression in vivo by hTERT targeting trans-splicing ribozyme. Journal of Nano & Bio Tech 5: 14-17.
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Kim, J., Jang, S., Lee, C. and Lee, S. (2008). Development of Trans-Splicing Aptazyme Which Can Specifically Modify Hepatitis C Virus Genome. The Korean Journal of Microbiology 44.
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Song, M. S. and Lee, S. W. (2008). In Vivo Target RNA Specificity of Trans-Splicing Phenomena by the Group I Intron. Genomics & Informatics 6(2): 84-86.
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Jeong, J. S., Lee, S. W., Hong, S. H., Lee, Y. J., Jung, H. I., Cho, K. S., Seo, H. H., Lee, S. J., Park, S., Song, M. S., Kim, C. M. and Kim, I. H. (2008). Antitumor effects of systemically delivered adenovirus harboring trans-splicing ribozyme in intrahepatic colon cancer mouse model. Clin Cancer Res 14(1): 281-290.
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Hong, S. H., Jeong, J. S., Lee, Y. J., Jung, H. I., Cho, K. S., Kim, C. M., Kwon, B. S., Sullenger, B. A., Lee, S. W.* and Kim, I. H.* (2008). In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells. Mol Ther 16(1): 74-80.
Reviews and chapters
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Lee, S. W. and Jeong, J. S. (2014). Use of tumor-targeting trans-splicing ribozyme for cancer treatment. Methods Mol Biol 1103: 83-95.
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Lee, C. H., and Lee, S.-W. (2013) Colony forming assay for HCV-replicon cell line. Bio-Protocol In press.
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Lee, S.-W. (2013) 'Trend analysis of gene therapy development' in Drug Research Trends. Bioin Special Webzine. No. 35.
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Lee, S. W. (2011). Introducing the Korean Oligonucleotide Therapeutics Society. Nucleic Acid Ther 21(3): 123.
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Lee, S. J., Lee, S. W., Jeong, J. S. and Kim, I. H. (2010). In vivo reprogramming of human telomerase reverse transcriptase (hTERT) by trans-splicing ribozyme to target tumor cells. Methods Mol Biol 629: 307-321.