Alessandra Boletta Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Italy
2 protocols

Marco Chiaravalli Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Italy
1 protocol

Isaline Rowe
  • Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Italy
Research focus
  • Cell biology
  • 2 Author merit


Ph.D., Laboratory of Physiology CNRS UMR 8572-USM 501 Evolution des régulations endocriniennes Museum National d'Histoire Naturelle, Paris, France, 2004

Current Position

Post-Doc fellow, Molecular Basis of Polycystic Kidney Disease Unit Director: Alessandra Boletta, Division of Genetics and Cell Biology, Dibit - San Raffaele, Via Olgettina 58, Milan, Italy (from July 2004 to date)


  1. Castelli, M., Boca, M., Chiaravalli, M., Ramalingam, H., Rowe, I., Distefano, G., Carroll, T. and Boletta, A. (2013). Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis. Nat Commun 4: 2658.
  2. Rowe, I., Chiaravalli, M., Mannella, V., Ulisse, V., Quilici, G., Pema, M., Song, X. W., Xu, H., Mari, S., Qian, F., Pei, Y., Musco, G. and Boletta, A. (2013). Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy. Nat Med 19(4): 488-493.
  3. Wodarczyk, C., Distefano, G., Rowe, I., Gaetani, M., Bricoli, B., Muorah, M., Spitaleri, A., Mannella, V., Ricchiuto, P., Pema, M., Castelli, M., Casanova, A. E., Mollica, L., Banzi, M., Boca, M., Antignac, C., Saunier, S., Musco, G. and Boletta, A. (2010). Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals. PLoS One 5(9): e12719.
  4. Wodarczyk, C.*, Rowe, I.*, Chiaravalli, M., Pema, M., Qian, F. and Boletta, A. (2009). A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One 4(9): e7137. *equal contribution
  5. Distefano, G., Boca, M., Rowe, I., Wodarczyk, C., Ma, L., Piontek, K. B., Germino, G. G., Pandolfi, P. P. and Boletta, A. (2009). Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol Cell Biol 29(9): 2359-2371.
  6. Coen, L., Le Blay, K., Rowe, I. and Demeneix, B. A. (2007). Caspase-9 regulates apoptosis/proliferation balance during metamorphic brain remodeling in Xenopus. Proc Natl Acad Sci U S A 104(20): 8502-8507.
  7. Rowe, I., Le Blay, K., Du Pasquier, D., Palmier, K., Levi, G., Demeneix, B. and Coen, L. (2005). Apoptosis of tail muscle during amphibian metamorphosis involves a caspase 9-dependent mechanism. Dev Dyn 233(1): 76-87.
  8. Rowe, I., Coen, L., Le Blay, K., Le Mevel, S. and Demeneix, B. A. (2002). Autonomous regulation of muscle fibre fate during metamorphosis in Xenopus tropicalis. Dev Dyn 224(4): 381-390.
2 Protocols published
Mitochondrial Transmembrane Potential (ψm) Assay Using TMRM
Authors:  Isaline Rowe and Alessandra Boletta, date: 12/05/2013, view: 26928, Q&A: 0
During cellular respiration, nutrients are oxidized to generate energy through a mechanism called oxidative phosphorylation, which occurs in the mitochondria. During oxidative phosphorylation, the gradual degradation of molecules through the TCA ...
ATP and Lactate Quantification
Authors:  Isaline Rowe, Marco Chiaravalli and Alessandra Boletta, date: 12/05/2013, view: 15558, Q&A: 0
Cells use glucose to generate energy by two different metabolic processes: lactic fermentation and aerobic respiration. In the first common series of reactions, glucose is converted into pyruvate. In anaerobic conditions, pyruvate is transformed ...
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