Education

Ph.D. in Biology, Autonomous University of Madrid, 1994

Current position

Senior Researcher, Department of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Madrid, Spain

Publications (since 2005)

1. Lopez-Sanchez, N., Ovejero-Benito, M. C., Rodríguez-Ruiz, C., Frade, J. M. (2013). NGF/p75^NTR in cell cycle and neuronal tetraploidy. En: The Handbook of Neurotoxicity^1st Edition Richard Kostrzewa (eds). Springer Verlag, Heidelberg In press
   
2. Lopez-Sanchez, N. and Frade, J. M. (2013). Genetic evidence for p75^NTR-dependent tetraploidy in cortical projection neurons from adult mice. J Neurosci 33(17): 7488-7500. (IF= 6.908)
   
3. Ovejero-Benito, M. C. and Frade, J. M. (2013). Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons. PLoS One 8(5): e64890. (IF= 3.730)
   
4. Formosa-Jordan, P., Ibanes, M., Ares, S. and Frade, J. M. (2013). Lateral inhibition and neurogenesis: novel aspects in motion. Int J Dev Biol 57(5): 341-350. (IF= 2.614)
   
5. Morillo, S. M., Abanto, E. P., Roman, M. J. and Frade, J. M. (2012). Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation. Mol Cell Biol 32(14): 2722-2737. (IF= 5.372)
   
6. Formosa-Jordan, P., Ibanes, M., Ares, S. and Frade, J. M. (2012). Regulation of neuronal differentiation at the neurogenic wavefront. Development 139(13): 2321-2329. (IF= 6.208)
   
7. Santos, A. M., Lopez-Sanchez, N., Martin-Oliva, D., de la Villa, P., Cuadros, M. A. and Frade, J. M. (2012). Sortilin participates in light-dependent photoreceptor degeneration in vivo. PLoS One 7(4): e36243. (IF= 3.730)
   
8. Garcia-Dominguez, D. J., Morello, D., Cisneros, E., Kontoyiannis, D. L. and Frade, J. M. (2011). Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis. Mol Biol Cell 22(8): 1227-1239. (IF= 4.803)
   
9. Lopez-Sanchez, N., Ovejero-Benito, M. C., Borreguero, L. and Frade, J. M. (2011). Control of neuronal ploidy during vertebrate development. Results Probl Cell Differ 53: 547-563.
   
10. Nikoletopoulou, V., Lickert, H., Frade, J. M., Rencurel, C., Giallonardo, P., Zhang, L., Bibel, M. and Barde, Y. A. (2010). Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature 467(7311): 59-63. (IF= 38.597)
    
11. Morillo, S. M., Escoll, P., de la Hera, A. and Frade, J. M. (2010). Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc Natl Acad Sci U S A 107(1): 109-114. (IF= 9.737)
    
12. Frade, J. M. and Lopez-Sanchez, N. (2010). A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75^NTR. Cell Cycle 9(10): 1934-1941. (IF= 5.321)
    
13. Frade, J. M. (2010). Somatic tetraploidy in vertebrate neurons: Implications in physiology and pathology. Commun Integr Biol 3(2): 201-203.
    
14. Latasa, M. J., Cisneros, E. and Frade, J. M. (2009). Cell cycle control of Notch signaling and the functional regionalization of the neuroepithelium during vertebrate neurogenesis. Int J Dev Biol 53(7): 895-908. (IF= 2.614)
    
15. Cisneros, E., Latasa, M. J., Garcia-Flores, M. and Frade, J. M. (2008). Instability of Notch1 and Delta1 mRNAs and reduced Notch activity in vertebrate neuroepithelial cells undergoing S-phase. Mol Cell Neurosci 37(4): 820-831. (IF= 3.837)
    
16. Morillo, S. M., Frade, J. M. (2008). Nerve growth factor signaling in neural cancer and metastasis. En: Nerve Growth Factor: New Research 1^st Edition Guy K. McIntire. (eds). NOVA Science Publishers, Inc., New York.
    
17. Lopez-Sanchez, N., Gonzalez-Fernandez, Z., Niinobe, M., Yoshikawa, K. and Frade, J. M. (2007). Single mage gene in the chicken genome encodes CMage, a protein with functional similarities to mammalian type II Mage proteins. Physiol Genomics 30(2): 156-171. (IF= 2.806)
    
18. Lopez-Sanchez, N., Rodriguez, J. R. and Frade, J. M. (2007). Mitochondrial c-Jun NH2-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support. Mol Cancer Res 5(1): 47-60. [Cover caption] (IF= 4.353)
    
19. Frade, J. M. (2006). Type II MAGE proteins at the crossroads of cell death and neurogenesis. En: Trends in Signal Transduction Research^1st Edition. Jennifer N. Meyers. (eds). NOVA Science Publishers, New York.
    
20. Frade, J. M. (2005). Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. J Neurosci 25(6): 1407-1411. (IF= 6.908)
    
21. Lopez-Sanchez, N., Muller, U. and Frade, J. M. (2005). Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein. Neuroscience 130(1): 51-60.. (IF= 3.122)