JUAN TORRAS Departament de Ciencies Clíniques, Universitat de Barcelona BARCELONA
1 protocol

Josep Maria Grinyo Department of Clinical Sciences. Bellvitge Campus. BARCELONA
1 protocol

Estanislao Navarro Independent researcher BARCELONA
1 protocol

Josep Maria Aran
  • Institut d’Investigació Biomèdica de Bellvitge-IDIBELL, BARCELONA
Research focus
  • Immunology
  • 2 Author merit


Ph.D. in Biochemistry, Department of Biochemistry and Physiology, University of Barcelona, 1990

Current position

National Health System Senior Investigator at the Molecular Genetics Laboratory

Head of the Immunoinflammatory Processess and Gene Therapeutics Group

Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de Llobregat, Barcelona

Publications (since 2008)

  1. Franquesa, M., Hoogduijn, M. J., Reinders, M. E., Eggenhofer, E., Engela, A. U., Mensah, F. K., Torras, J., Pileggi, A., van Kooten, C., Mahon, B., Detry, O., Popp, F. C., Benseler, V., Casiraghi, F., Johnson, C., Ancans, J., Fillenberg, B., delaRosa, O., Aran, J. M., Roemeling-vanRhijn, M., Pinxteren, J., Perico, N., Gotti, E., Christ, B., Reading, J., Introna, M., Deans, R., Shagidulin, M., Farre, R., Rambaldi, A., Sanchez-Fueyo, A., Obermajer, N., Pulin, A., Dor, F. J., Portero-Sanchez, I., Baan, C. C., Rabelink, T. J., Remuzzi, G., Betjes, M. G., Dahlke, M. H. and Grinyo, J. M. (2013). Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: lessons learned from first clinical trials. Transplantation 96(3): 234-238. (I.F.=4.003)
  2. Ripoll, E., Merino, A., Goma, M., Aran, J. M., Bolanos, N., de Ramon, L., Herrero-Fresneda, I., Bestard, O., Cruzado, J. M., Grinyo, J. M. and Torras, J. (2013). CD40 gene silencing reduces the progression of experimental lupus nephritis modulating local milieu and systemic mechanisms. PLoS One 8(6): e65068. (I.F.=4.092)
  3. Olivar, R., Luque, A., Naranjo-Gomez, M., Quer, J., Garcia de Frutos, P., Borras, F. E., Rodriguez de Cordoba, S., Blom, A. M. and Aran, J. M. (2013). The α7β0 isoform of the complement regulator C4b-binding protein induces a semimature, anti-inflammatory state in dendritic cells. J Immunol 190(6): 2857-2872. (I.F.=5.788)
  4. Martinez-Gonzalez, I., Roca, O., Masclans, J. R., Moreno, R., Salcedo, M. T., Baekelandt, V., Cruz, M. J., Rello, J. and Aran, J. M. (2013). Human mesenchymal stem cells overexpressing the IL-33 antagonist soluble IL-1 receptor-like-1 attenuate endotoxin-induced acute lung injury. Am J Respir Cell Mol Biol 49(4): 552-562. (I.F.=5.125)
  5. Moreno, R., Martinez-Gonzalez, I., Rosal, M., Nadal, M., Petriz, J., Gratacos, E. and Aran, J. M. (2012). Fetal liver-derived mesenchymal stem cell engraftment after allogeneic in utero transplantation into rabbits. Stem Cells Dev 21(2): 284-295. (I.F.=4.79)
  6. Martinez-Gonzalez, I., Moreno, R., Petriz, J., Gratacos, E. and Aran, J. M. (2012). Engraftment potential of adipose tissue-derived human mesenchymal stem cells after transplantation in the fetal rabbit. Stem Cells Dev 21(18): 3270-3277. (I.F.=4.79)
  7. Moreno, R., Martinez, I., Petriz, J., Nadal, M., Tintore, X., Gonzalez, J. R., Gratacos, E. and Aran, J. M. (2011). The β-interferon scaffold attachment region confers high-level transgene expression and avoids extinction by epigenetic modifications of integrated provirus in adipose tissue-derived human mesenchymal stem cells. Tissue Eng Part C Methods 17(3): 275-287. (I.F.=4.64)
  8. Ripoll, E., Pluvinet, R., Torras, J., Olivar, R., Vidal, A., Franquesa, M., Cassis, L., Cruzado, J. M., Bestard, O., Grinyo, J. M., Aran, J. M.* and Herrero-Fresneda, I. (2011). In vivo therapeutic efficacy of intra-renal CD40 silencing in a model of humoral acute rejection. Gene Ther 18(10): 945-952. (I.F.=4.538) *Share senior co-authorship
  9. Balbuena, J., Pachon, G., Lopez-Torrents, G., Aran, J. M., Castresana, J. S. and Petriz, J. (2011). ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties. Cytometry A 79(9): 672-683. (I.F.=3.749)
  10. Wartenberg, M., Richter, M., Datchev, A., Gunther, S., Milosevic, N., Bekhite, M. M., Figulla, H. R., Aran, J. M., Petriz, J. and Sauer, H. (2010). Glycolytic pyruvate regulates P-Glycoprotein expression in multicellular tumor spheroids via modulation of the intracellular redox state. J Cell Biochem 109(2): 434-446. (I.F.=3.12)
  11. Moreno, R., Martinez-Gonzalez, I., Rosal, M., Farwati, A., Gratacos, E. and Aran, J. M. (2010). Characterization of mesenchymal stem cells isolated from the rabbit fetal liver. Stem Cells Dev 19(10): 1579-1588. (I.F.=4.79)
  12. Moreno, R., Martinez, I., Petriz, J., Gonzalez, J. R., Gratacos, E. and Aran, J. M. (2009). Boundary sequences stabilize transgene expression from subtle position effects in retroviral vectors. Blood Cells Mol Dis 43(2): 214-220. (I.F.=2.90)
  13. Gene, G. G., Llobet, A., Larriba, S., de Semir, D., Martinez, I., Escalada, A., Solsona, C., Casals, T. and Aran, J. M. (2008). N-terminal CFTR missense variants severely affect the behavior of the CFTR chloride channel. Hum Mutat 29(5): 738-749. (I.F.=7.03)
  14. Moreno, R., Rosal, M., Martinez, I., Vilardell, F., Gonzalez, J. R., Petriz, J., Hernandez-Andrade, E., Gratacos, E. and Aran, J. M. (2008). Restricted transgene persistence after lentiviral vector-mediated fetal gene transfer in the pregnant rabbit model. J Gene Med 10(9): 951-964. (I.F.=3.14)
  15. Pluvinet, R., Olivar, R., Krupinski, J., Herrero-Fresneda, I., Luque, A., Torras, J., Cruzado, J. M., Grinyo, J. M., Sumoy, L. and Aran, J. M. (2008). CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling. Blood 112(9): 3624-3637.
2 Protocols published
In vivo CD40 Silencing by siRNA Infusion in Rodents and Evaluation by Kidney Immunostaining

The co-stimulatory molecule CD40 and its ligand CD40L play a key role in the regulation of immunological processes and are involved in the pathophysiology of autoimmune and inflammatory diseases. Inhibition of the CD40-CD40L axis is a promising

Assessment of Human Dendritic Cell Antigen Uptake by Flow Cytometry
Authors:  Ana Luque, Sonia Cárdenas-Brito, Rut Olivar and Josep M. Aran, date: 11/20/2013, view: 16680, Q&A: 0
Antigen uptake by dendritic cells is the first key step towards induction of antigen-specific T-cell responses. This flow cytometry-based protocol describes the analysis of dendritic cell uptake of soluble antigens through two different mechanisms: ...
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