Alpha Yap Divisions of Cell and Developmental Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland, 4072
1 protocol

Ivar Noordstra The University of Queensland
1 protocol

Kinga Duszyc The University of Queensland Brisbane
1 protocol

Magdalene Michael Randall Division of Cell and Molecular Biophysics, King’s College London, Guy’s Campus, UK
2 protocols
Alka Mehra Institute of Genomics and Integrative Biology
45 protocols

Andrea Introini Karolinska Institutet
10 protocols

Hsin-Yi Chang Kyoto University
7 protocols

Jia Li SRI International
51 protocols

Editor
Guillermo A. Gomez
  • Faculty, The University of Queensland
Research focus
  • 4 Author merit

Education

PhD, National University of Cordoba, 2008

Lab information

Guillermo Gomez's lab

Research interest: Physical forces are a key determinant of tissue architecture controlling also cellular behaviours that range from the differentiation of stem cells to cell transformation and cancer invasion. We have made significant progress in understanding the mechanisms involved in capacity of the cells to generate forces and the regulation of epithelial organization. We now are using this knowledge to understand how dysregulation of tissue mechanics contributes to the loss of tissue architecture and organ function.
https://ccb.unisa.edu.au/research/laboratories/Tissue_Architecture_and_Organ_Function_Laboratory/

Publications

4 Protocols published
Live Imaging of Apoptotic Extrusion and Quantification of Apical Extrusion in Epithelial Cells
Authors:  Kinga Duszyc, Ivar Noordstra, Alpha S. Yap and Guillermo A. Gomez, date: 11/20/2021, view: 1632, Q&A: 0

Apoptotic cell death eliminates unhealthy cells and maintains homeostatic cell numbers within tissues. Epithelia, which serve as fundamental tissue barriers for the body, depend on a physical expulsion of dying cells (apoptotic cell extrusion) to

...
Measurement of Mechanical Tension at cell-cell junctions using two-photon laser ablation
Authors:  Xuan Liang, Magdalene Michael and Guillermo A. Gomez, date: 12/20/2016, view: 9030, Q&A: 1
The cortical actomyosin cytoskeleton is found in all non-muscle cells where a key function is to control mechanical force (Salbreux et al., 2012). When coupled to E-cadherin cell-cell adhesion, cortical actomyosin generates junctional ...
5 Protocols reviewed
Isolation of Microglia and Analysis of Protein Expression by Flow Cytometry: Avoiding the Pitfall of Microglia Background Autofluorescence
Authors:  Jeremy C. Burns, Richard M. Ransohoff and Michaël Mingueneau, date: 07/20/2021, view: 3030, Q&A: 0

Microglia are a unique type of tissue-resident innate immune cell found within the brain, spinal cord, and retina. In the healthy nervous system, their main functions are to defend the tissue against infectious microbes, support neuronal networks

...
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Analysis of Random Migration of Cancer Cells in 3D
Authors:  Sai P. Visweshwaran and Alexis Gautreau, date: 01/05/2020, view: 4295, Q&A: 1
The ability of cancer cells to migrate through a complex three-dimensional (3D) environment is a hallmark event of cancer metastasis. Therefore, an in vitro migration assay to evaluate cancer cell migration in a 3D setting is valuable to ...
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2 Protocols edited
Analysis of Cancer Stromal Reaction Using an O-ring Co-culture Assay
Author:  Vivien Jane Coulson-Thomas, date: 02/20/2017, view: 7828, Q&A: 0
We have developed a 2D heterotypic co-culture technique between fibroblasts and cancer cells that enables the study of the stromal reaction. For such, stromal cells are seeded and cultured immediately around a tumour cell line, and the cells ...
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Mouse Mammary Intraductal (MIND) Method for Transplantation of Patient Derived Primary DCIS Cells and Cell Lines
Authors:  Frances Kittrell, Kelli Valdez, Hanan Elsarraj, Yan Hong, Daniel Medina and Fariba Behbod, date: 03/05/2016, view: 8950, Q&A: 0
The MIND method involves intraductal injection of patient derived ductal carcinoma in situ (DCIS) cells and DCIS cell lines (MCF10DCIS.COM and SUM225) inside the mouse mammary ducts [Video 1 and Figure 1 in Behbod et al. (2009)]. This ...
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