Akio Tsuru
  • Graduate School of Biological Sciences, Nara Institute of Science and Technology, Japan
Research fields
  • Cell biology
Personal information


Ph.D. in Medical Sciences, Department of Cell Biology, Kyoto University, 1991

Current position

Assistant Professor, Laboratory of Molecular and Cell Genetics, Nara Institute of Science and Technolgy (NAIST), Japan


  1. Kadokura, H., Saito, M., Tsuru, A., Hosoda, A., Iwawaki, T., Inaba, K. and Kohno, K. (2013). Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue. Biochem Biophys Res Commun.
  2. Tsuru, A., Fujimoto, N., Takahashi, S., Saito, M., Nakamura, D., Iwano, M., Iwawaki, T., Kadokura, H., Ron, D. and Kohno, K. (2013). Negative feedback by IRE1β optimizes mucin production in goblet cells. Proc Natl Acad Sci U S A 110(8): 2864-2869.
  3. Sopha, P., Kadokura, H., Yamamoto, Y. H., Takeuchi, M., Saito, M., Tsuru, A. and Kohno, K. (2012). A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins. Cell Struct Funct 37(2): 177-187.
  4. Nakamura, D., Tsuru, A., Ikegami, K., Imagawa, Y., Fujimoto, N. and Kohno, K. (2011). Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins. FEBS Lett 585(1): 133-138.
  5. Imagawa, Y., Hosoda, A., Sasaka, S., Tsuru, A. and Kohno, K. (2008). RNase domains determine the functional difference between IRE1α and IRE1β. FEBS Lett 582(5): 656-660.
  6. Hosoda, A., Kimata, Y., Tsuru, A. and Kohno, K. (2003). JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs. J Biol Chem 278(4): 2669-2676.
  7. Saito, M., Iwawaki, T., Taya, C., Yonekawa, H., Noda, M., Inui, Y., Mekada, E., Kimata, Y., Tsuru, A. and Kohno, K. (2001). Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol 19(8): 746-750.
  8. Iwawaki, T., Hosoda, A., Okuda, T., Kamigori, Y., Nomura-Furuwatari, C., Kimata, Y., Tsuru, A. and Kohno, K. (2001). Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. Nat Cell Biol 3(2): 158-164.
  9. Kimata, Y., Ooboki, K., Nomura-Furuwatari, C., Hosoda, A., Tsuru, A. and Kohno, K. (2000). Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search. Gene 261(2): 321-327.
  10. Okamura, K., Kimata, Y., Higashio, H., Tsuru, A. and Kohno, K. (2000). Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast. Biochem Biophys Res Commun 279(2): 445-450.
  11. Nakamura, N., Tsuru, A., Hirayoshi, K. and Nagata, K. (1992). Purification and characterization of a vimentin-specific protease in mouse myeloid leukemia cells. Regulation during differentiation and identity with cathepsin G. Eur J Biochem 205(3): 947-954.
  12. Michishita, M., Hirayoshi, K., Tsuru, A., Nakamura, N., Yoshida, Y., Okuma, M. and Nagata, K. (1991). Effects of type-β 1 transforming growth factor on the proliferation and differentiation of mouse myelomonocytic leukemia cells (M1). Exp Cell Res 196(1): 107-113.
  13. Hirayoshi, K., Tsuru, A., Yamashita, M., Tomida, M., Yamamoto-Yamaguchi, Y., Yasukawa, K., Hozumi, M., Goeddel, D. V. and Nagata, K. (1991). Both D factor/LIF and IL-6 inhibit the differentiation of mouse teratocarcinoma F9 cells. FEBS Lett 282(2): 401-404.
  14. Tsuru, A., Nakamura, N., Takayama, E., Suzuki, Y., Hirayoshi, K. and Nagata, K. (1990). Regulation of the expression of vimentin gene during the differentiation of mouse myeloid leukemia cells. J Cell Biol 110(5): 1655-1664.
  15. Yamaguchi, T., Tsuru, A. and Washio, H. (1987). L-glutamate and potassium-induced contractures in denervated cockroach muscles. Comp Biochem Physiol C 87(2): 401-407.
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