Education

M.D., Shanghai 2^nd Medical University, Shanghai, China, 1983

Ph.D., Specialist in Pharmacological Research, Lombardy Regional School of Professional Education in Pharmacology, Milan, Italy, 1987

Current position

Senior Principal Investigator, Center for Cancer Research, National Cancer Institute, Frederick, MD

Publications (since 2008)

1. Yao, X., Liu, Y., Chen, K., Liu, M., Yoshimura, T., Gong, W., Ping, Y., Wang, J. M., Bian, X. (JMW and XB are co-corresponding authors). A critical role for the vascular endothelial cell growth factor receptor 2 in glioblastoma tumor initiating cell renewal, tumorigenesis and the formation of vascular mimicry. PLoS ONE In press
   
2. Yoshimura, T., Howard, O. M., Ito, T., Kuwabara, M., Matsukawa, A., Chen, K., Liu, Y., Liu, M., Oppenheim, J. J. and Wang, J. M. (2013). Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells. PLoS ONE 8(3): e58791.
   
3. Wantha, S., Alard, J. E., Megens, R. T., van der Does, A. M., Doring, Y., Drechsler, M., Pham, C. T., Wang, M. W., Wang, J. M., Gallo, R. L., von Hundelshausen, P., Lindbom, L., Hackeng, T., Weber, C. and Soehnlein, O. (2013). Neutrophil-derived cathelicidin promotes adhesion of classical monocytes. Circ Res 112(5): 792-801.
   
4. Liu, Y., Chen, K., Wang, C., Gong, W., Yoshimura, T., Liu, M. and Wang, J. M. (2013). Cell surface receptor FPR2 promotes antitumor host defense by limiting M2 polarization of macrophages. Cancer Res 73(2): 550-560.
   
5. Chen, K., Liu, M., Liu, Y., Yoshimura, T., Shen, W., Le, Y., Durum, S., Gong, W., Wang, C., Gao, J. L., Murphy, P. M. and Wang, J. M. (2013). Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis. J Clin Invest 123(4): 1694-1704.
   
6. Li, Z., Mou, H., Wang, T., Xue, J., Deng, B., Qian, L., Zhou, Y., Gong, W., Wang, J. M., Wu, G., Zhou, C. F., Fang, J. and Le, Y. (2013). A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression. Cancer Lett 328(2): 278-284.
   
7. Arroyo, D. S., Soria, J. A., Gaviglio, E. A., Garcia-Keller, C., Cancela, L. M., Rodriguez-Galan, M. C., Wang, J. M. and Iribarren, P. (2013). Toll-like receptor 2 ligands promote microglial cell death by inducing autophagy. FASEB J 27(1): 299-312.
   
8. Mou, H., Li, Z., Kong, Y., Deng, B., Qian, L., Wang, J. M. and Le, Y. (2012). Proinflammatory stimulants promote the expression of a promiscuous G protein-coupled receptor, mFPR2, in microvascular endothelial cells. Inflammation 35(2): 656-664.
   
9. Liu, M., Chen, K., Yoshimura, T., Liu, Y., Gong, W., Wang, A., Gao, J. L., Murphy, P. M. and Wang, J. M. (2012). Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes. Sci Rep 2: 786.
   
10. Liu, M., Zhao, J., Chen, K., Bian, X., Wang, C., Shi, Y. and Wang, J. M. (2012). G protein-coupled receptor FPR1 as a pharmacologic target in inflammation and human glioblastoma. Int Immunopharmacol 14(3): 283-288.
    
11. Yavlovich, A., Viard, M., Zhou, M., Veenstra, T. D., Wang, J. M., Gong, W., Heldman, E., Blumenthal, R. and Raviv, Y. (2012). Ectopic ATP synthase facilitates transfer of HIV-1 from antigen-presenting cells to CD4(+) target cells. Blood 120(6): 1246-1253.
    
12. Bena, S., Brancaleone, V., Wang, J. M., Perretti, M. and Flower, R. J. (2012). Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling. J Biol Chem 287(29): 24690-24697.
    
13. Yu, S. C., Xiao, H. L., Jiang, X. F., Wang, Q. L., Li, Y., Yang, X. J., Ping, Y. F., Duan, J. J., Jiang, J. Y., Ye, X. Z., Xu, S. L., Xin, Y. H., Yao, X. H., Chen, J. H., Chu, W. H., Sun, W., Wang, B., Wang, J. M., Zhang, X. and Bian, X. W. (2012). Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin. Stem Cells 30(2): 108-120.
    
14. Yang, Y., Liu, Y., Yao, X., Ping, Y., Jiang, T., Liu, Q., Xu, S., Huang, J., Mou, H., Gong, W., Chen, K., Bian, X. and Wang, J. M. (2011). Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1. Am J Pathol 179(3): 1504-1512.
    
15. Iribarren, P. and Wang, J. M. (2011). Toll-like receptors and diseases. Int Immunopharmacol 11(10): 1389-1390.
    
16. Yao, X. H., Liu, Y., Chen, K., Gong, W., Liu, M. Y., Bian, X. W. and Wang, J. M. (2011). Chemoattractant receptors as pharmacological targets for elimination of glioma stem-like cells. Int Immunopharmacol 11(12): 1961-1966.
    
17. Yang, Y., Liu, Y., Yao, X., Ping, Y., Jiang, T., Liu, Q., Xu, S., Huang, J., Mou, H., Gong, W., Chen, K., Bian, X. and Wang, J. M. (2011). Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1. Am J Pathol 179(3): 1504-1512.
    
18. Chen, K., Xiang, Y., Yao, X., Liu, Y., Gong, W., Yoshimura, T. and Wang, J. M. (2011). The active contribution of Toll-like receptors to allergic airway inflammation. Int Immunopharmacol 11(10): 1391-1398.
    
19. Soria, J. A., Arroyo, D. S., Gaviglio, E. A., Rodriguez-Galan, M. C., Wang, J. M. and Iribarren, P. (2011). Interleukin 4 induces the apoptosis of mouse microglial cells by a caspase-dependent mechanism. Neurobiol Dis 43(3): 616-624.
    
20. Ping, Y. F., Yao, X. H., Jiang, J. Y., Zhao, L. T., Yu, S. C., Jiang, T., Lin, M. C., Chen, J. H., Wang, B., Zhang, R., Cui, Y. H., Qian, C., Wang, J. and Bian, X. W. (2011). The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling. J Pathol 224(3): 344-354.
    
21. Lin, Q., Fang, D., Hou, X., Le, Y., Fang, J., Wen, F., Gong, W., Chen, K., Wang, J. M. and Su, S. B. (2011). HCV peptide (C5A), an amphipathic alpha-helical peptide of hepatitis virus C, is an activator of N-formyl peptide receptor in human phagocytes. J Immunol 186(4): 2087-2094.
    
22. Lin, Q., Yang, X. P., Fang, D., Ren, X., Zhou, H., Fang, J., Liu, X., Zhou, S., Wen, F., Yao, X., Wang, J. M. and Su, S. B. (2011). High-mobility group box-1 mediates toll-like receptor 4-dependent angiogenesis. Arterioscler Thromb Vasc Biol 31(5): 1024-1032.
    
23. Xia, X., Park, E., Liu, B., Willette-Brown, J., Gong, W., Wang, J., Mitchell, D., Fischer, S. M. and Hu, Y. (2010). Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis. Am J Pathol 176(5): 2500-2508.
    
24. Chen, K., Le, Y., Liu, Y., Gong, W., Ying, G., Huang, J., Yoshimura, T., Tessarollo, L. and Wang, J. M. (2010). A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses. J Immunol 184(7): 3331-3335.
    
25. Huang, J., Chen, K., Chen, J., Gong, W., Dunlop, N. M., Howard, O. M., Gao, Y., Bian, X. W. and Wang, J. M. (2010). The G-protein-coupled formylpeptide receptor FPR confers a more invasive phenotype on human glioblastoma cells. Br J Cancer 102(6): 1052-1060.
    
26. Chen, K., Huang, J., Liu, Y., Gong, W., Cui, Y. and Wang, J. M. (2009). Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells. J Neuroimmunol 213(1-2): 69-77.
    
27. Zhu, J., Wang, O., Ruan, L., Hou, X., Cui, Y., Wang, J. M. and Le, Y. (2009). The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR. Int Immunopharmacol 9(9): 1126-1130.
    
28. Huang, J., Chen, K., Gong, W., Dunlop, N. M., Howard, O. M., Bian, X., Gao, Y. and Wang, J. M. (2009). Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation. Carcinogenesis 30(2): 348-355.
    
29. Bian, X. W., Xu, J. P., Ping, Y. F., Wang, Y., Chen, J. H., Xu, C. P., Wu, Y. Z., Wu, J., Zhou, X. D., Chen, Y. S., Shi, J. Q. and Wang, J. M. (2008). Unique proteomic features induced by a potential antiglioma agent, Nordy (dl-nordihydroguaiaretic acid), in glioma cells. Proteomics 8(3): 484-494.
    
30. Meng, X. L., Yang, J. Y., Chen, G. L., Zhang, L. J., Wang, L. H., Li, J., Wang, J. M. and Wu, C. F. (2008). RV09, a novel resveratrol analogue, inhibits NO and TNF-alpha production by LPS-activated microglia. Int Immunopharmacol 8(8): 1074-1082.
    
31. Attal, H., Cohen-Hillel, E., Meshel, T., Wang, J. M., Gong, W. and Ben-Baruch, A. (2008). Intracellular cross-talk between the GPCR CXCR1 and CXCR2: role of carboxyl terminus phosphorylation sites. Exp Cell Res 314(2): 352-365.
    
32. Yu, S. C., Ping, Y. F., Yi, L., Zhou, Z. H., Chen, J. H., Yao, X. H., Gao, L., Wang, J. M. and Bian, X. W. (2008). Isolation and characterization of cancer stem cells from a human glioblastoma cell line U87. Cancer Lett 265(1): 124-134.
    
33. Yao, X. H., Ping, Y. F., Chen, J. H., Xu, C. P., Chen, D. L., Zhang, R., Wang, J. M. and Bian, X. W. (2008). Glioblastoma stem cells produce vascular endothelial growth factor by activation of a G-protein coupled formylpeptide receptor FPR. J Pathol 215(4): 369-376.
    
34. Huang, J., Chen, K., Gong, W., Zhou, Y., Le, Y., Bian, X. and Wang, J. M. (2008). Receptor "hijacking" by malignant glioma cells: a tactic for tumor progression. Cancer Lett 267(2): 254-261.
    
35. Huang, J., Chen, K., Gong, W., Dunlop, N. M. and Wang, J. M. (2008). G-protein coupled chemoattractant receptors and cancer. Front Biosci 13: 3352-3363.
    
36. Chen, K., Zhang, L., Huang, J., Gong, W., Dunlop, N. M. and Wang, J. M. (2008). Cooperation between NOD2 and Toll-like receptor 2 ligands in the up-regulation of mouse mFPR2, a G-protein-coupled Abeta42 peptide receptor, in microglial cells. J Leukoc Biol 83(6): 1467-1475.
    
37. Song, C., Xiao, Z., Nagashima, K., Li, C. C., Lockett, S. J., Dai, R. M., Cho, E. H., Conrads, T. P., Veenstra, T. D., Colburn, N. H., Wang, Q. and Wang, J. M. (2008). The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation. Toxicol Appl Pharmacol 228(3): 351-363.
    
38. Tohno, M., Ueda, W., Azuma, Y., Shimazu, T., Katoh, S., Wang, J. M., Aso, H., Takada, H., Kawai, Y., Saito, T. and Kitazawa, H. (2008). Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-2 (NOD2). Mol Immunol 45(1): 194-203.
    
39. Attal, H., Cohen-Hillel, E., Meshel, T., Wang, J. M., Gong, W. and Ben-Baruch, A. (2008). Intracellular cross-talk between the GPCR CXCR1 and CXCR2: role of carboxyl terminus phosphorylation sites. Exp Cell Res 314(2): 352-365.
    

Manuscripts in press

1. Chen, K., Liu, Y., Wang, C., Liu, M., Yoshimura, T., Gong, W., Le Y, Wang, J.M. Signal relay by chemoattractant receptors in inflammatory dendritic cell recruitment into the airway. J Biol Chem
   
2. Lammermann, T., Afonso, P. V., Angermann, B. R., Wang, J. M., Parent, C. A., and Germain, R. N. Molecular control of neutrophil swarming at sites of cell damage in vivo. Nature
   

Book Chapters

1. Wang, J.M. and Chen, K. (2005). Chemotactic peptide ligands for formylpeptide receptors influencing inflammation. In: The Handbook of Peptides, Kastin, A.J. (Ed.), Academic Press, Elsevier, London, UK, 547-552.
   
2. Yao, X., Liu, Y., Huang, J., Zhou, Y., Bian, X., and Wang, J. M. (2011). The role of chemoattractant receptors in the progression of glioma. In: Glioma (Book1), Edited by: Lazinica, A. InTech Open Access Publisher, Vienna, Austria, European Union. ISBN 978-953-307-379-8.
   
3. Liu, Y., Chen, K., and Wang, J. M. (2011). The ligands for the G protein-coupled formyl peptide receptors (FPRs) involved in inflammation and immune responses. In: The Handbook of Peptides, Kastin, A. . (Ed.), Academic Press, Elsevier, London, UK (2011, Second Edition).